Controlo da hiperglicemia na síndrome coronária aguda

Autores

  • Nelson Pedro Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Ávila Costa Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • J. J. Moura Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Mário Freitas Serviço de Medicina II dos Hospitais da Universidade de Coimbra
  • Luís Providência Serviço de Medicina II dos Hospitais da Universidade de Coimbra

Palavras-chave:

hiperglicémia, síndrome coronária aguda

Resumo

Além da evidente associação entre a diabetes e resistência
à insulina e a doença coronária, a constatação da presença
frequente de hiperglicémia na Síndrome Coronária Aguda e a
noção da sua relação com evolução desfavorável, permitem uma
abordagem a esta temática na tentativa de melhorar a actuação nesta patologia.
Nos últimos anos, vários estudos permitiram estabelecer com
segurança, a relação entre hiperglicémia e evolução desfavorável
no SCA, bem como o efeito benéfico do controlo terapêutico adequado.
Recentemente a American Heart Association publicou uma
norma científica sobre este tema.
Os autores pretendem, com este artigo de revisão, sugerir uma
actuação adequada para controlo da hiperglicémia no doente com
Síndrome Coronária Aguda.

Downloads

Não há dados estatísticos.

Referências

Sean M. Donahoe, MD et al. Diabetes and Mortality Following Acute Coronary Syndromes; JAMA 2007;298(7):765-775.

Kristen Franklin, MD et al. Implications of Diabetes in Patients With Acute Coronary Syndromes; Arch Intern Med 2004;164:1457-1463.

Prakash Deedwania, et al.Hyperglycemia and Acute Coronary Syndrome: A Scientific Statement From the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism; Circulation 2008;117;1610-1619.

Kersten JR, Toller WG, Tessmer JP, Pagel PS, Warltier DC. Hyperglycemia reduces coronary collateral blood flow through a nitric oxidemediated mechanism. Am J Physiol Heart Circ Physiol 2001;281:2097-2104.

Kersten JR, Schmeling TJ, Orth KG, Pagel PS, Warltier DC. Acute hyperglycemia abolishes ischemic preconditioning in vivo. Am J Physiol

;275(2):721-725.

Scognamiglio R, Negut C, De Kreutzenberg SV, Tiengo A, Avogaro A. Postprandial myocardial perfusion in healthy subjects and in type 2 diabetic patients. Circulation 2005;112:179-184.

Scognamiglio R, Negut C, de Kreutzenberg SV, Tiengo A, Avogaro A. Effects of different insulin regimes on postprandial myocardial perfusion defects in type 2 diabetic patients. Diabetes Care 2006;29:95-100.

Pandolfi A, Giaccari A, Cilli C, Alberta MM, Morviducci L, De Filippis EA, Buongiorno A, Pellegrini G, Capani F, Consoli A. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol 2001;38:71-76.

Gresele P, Guglielmini G, De Angelis M, Ciferri S, Ciofetta M, Falcinelli E, Lalli C, Ciabattoni G, Davi G, Bolli GB. Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitus. J Am Coll Cardiol 2003;41:1013-1020.

Morohoshi M, Fujisawa K, Uchimura I, Numano F. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Diabetes 1996;45:954 -959.

Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002;106:2067-2072.

Guha M, Bai W, Nadler JL, Natarajan R. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and –independent pathways. J Biol Chem 2000;275:17728-17739.

Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J Clin Endocrinol Metab 2000;85:2970-2973.

Tansey MJ, Opie LH. Relation between plasma free fatty acids and arrhythmias within the first twelve hours of acute myocardial infarction. Lancet 1983;2:419-422.

Oliver MF. Metabolic causes and prevention of ventricular fibrillation during acute coronary syndromes. Am J Med 2002;112:305-311.

Hadjadj S, Coisne D, Mauco G, Ragot S, Duengler F, Sosner P, Torremocha F, Herpin D, Marechaud R. Prognostic value of admission plasma glucose and HbA in acute myocardial infarction. Diabet Med 2004;21:305-310.

Malmberg K; DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ. 1997;314:1512-1515.

Malmberg K, Norhammar A, Wedel H, Ryden L. Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study. Circulation 1999;99:2626-2632.

Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A; DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J. 2005;26:650-661.

Christos Pitsavos et al. Characteristics and In-hospital Mortality of Diabetics and Nondiabetics with An Acute Coronary Syndrome; The GREECS Study; Clin Cardiol 2007;30(5):239-244.

Kristen Franklin, MD et al. Implications of Diabetes in Patients With Acute Coronary Syndromes; Arch Intern Med 2004;164:1457-1463.

Pamela N Peterson et al. The impact of diabetes on one-year health status outcomes following acute coronary syndromesM; BMC Cardiovascular Disorders 2006, 6:41 doi:10.1186/1471-2261-6-4

Ficheiros Adicionais

Publicado

31-12-2010

Como Citar

1.
Pedro N, Costa Ávila, Moura JJ, Freitas M, Providência L. Controlo da hiperglicemia na síndrome coronária aguda. RPMI [Internet]. 31 de Dezembro de 2010 [citado 19 de Junho de 2024];17(4):258-62. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1193

Edição

Secção

Artigos de Revisão

Artigos mais lidos do(s) mesmo(s) autor(es)

1 2 > >>