Obrigado, Dr. de Fronzo!

Autores

  • C. Godinho Unidade de Diabetologia do Hospital de Faro, EPE
  • E. Gomes Unidade de Diabetologia do Hospital de Faro, EPE

Palavras-chave:

De Fronzo, controlo glicémico, insulina na diabetes tipo 2

Resumo

Os autores revêem a relação entre o controlo glicémico e as
complicações da Diabetes: relação estabelecida e demonstrada
no caso das complicações microangiopáticas mas controversa
e contraditória no caso da macroangiopatia, questionando os
objectivos do controlo “cego”das glicemias independentemente do doente concreto.
Revêem o conceito do “octeto” de De Fronzo, que advoga o
recurso prioritário a fármacos que aumentem a sensibilidade à
insulina e que preservem a função da célula β, pondo em causa
a utilização indiscriminada de vários hipoglicemiantes (incluindo
a insulina) devido ao seu papel potencialmente aterogénico. A
insulina poderia mesmo ser considerada a wrong drug na prevenção das doenças cardiovasculares.

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Referências

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Ficheiros Adicionais

Publicado

30-12-2011

Como Citar

1.
Godinho C, Gomes E. Obrigado, Dr. de Fronzo!. RPMI [Internet]. 30 de Dezembro de 2011 [citado 6 de Dezembro de 2024];18(4):269-73. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1351

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