Síndromes reno-pulmonares associadas a anticorpo anticitoplasma do neutrófilo

Autores

  • Irina Didenko Serviço de Imunoalergologia / Laboratório de Imunologia e Biologia Molecular, Centro Hospitalar de Setúbal, E.P.E. Hospital São Bernardo
  • Sara Correia Serviço de Imunoalergologia / Laboratório de Imunologia e Biologia Molecular, Centro Hospitalar de Setúbal, E.P.E. Hospital São Bernardo
  • Fátima Ferreira Serviço de Imunoalergologia, Centro Hospitalar de Setúbal, E.P.E. Hospital São Bernardo
  • Vítor Augusto Centro Hospitalar de Setúbal, E.P.E. Hospital São Bernardo

Palavras-chave:

ANCA, vasculite, granulomatose de Wegener, poliangeíte microscópica, síndrome de Churg-Strauss

Resumo

A síndrome reno-pulmonar é caracterizada pela associação de
hemorragia alveolar e glomerulonefrite rapidamente progressiva
(GNRP), no contexto de doenças graves, frequentemente associadas a positividade sérica para o anticorpo anticitoplasma do
neutrófilo (ANCA). A granulomatose de Wegener (WG), a poliangeíte microscópica (MPA) e a síndrome de Churg-Strauss (CSS)
são entidades descritas como vasculites de pequenos vasos
fortemente associados a ANCA. A síndrome reno-pulmonar é a
manifestação clínica mais frequente da vasculite sistémica. O
diagnóstico de vasculite associada a ANCA baseia-se em manifestações clínicas, biopsia do órgão afectado e presença sérica
de ANCA. No entanto, a inclusão de ANCA no estabelecimento do
diagnóstico permanece controversa. A compreensão de pontos-chave na patogénese da vasculite associada a ANCA pode, sem
dúvida, levar a uma abordagem terapêutica mais eficaz.

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Publicado

31-03-2009

Como Citar

1.
Didenko I, Correia S, Ferreira F, Augusto V. Síndromes reno-pulmonares associadas a anticorpo anticitoplasma do neutrófilo. RPMI [Internet]. 31 de Março de 2009 [citado 14 de Julho de 2024];16(1):52-61. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1387

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