Fenótipos de Diabetes Mellitus e Insuficiência Cardíaca

Autores

DOI:

https://doi.org/10.24950/rspmi.1600

Palavras-chave:

Biomarcadores, Diabetes Mellitus, Fenótipo, Insuficiência Cardíaca

Resumo

A classificação de patologias de acordo com as características específicas dos doentes não é exclusiva da insuficiência cardíaca ou da diabetes mellitus. Contudo, com o surgimento de várias novas terapêuticas que demonstraram benefício no prognóstico de ambas as patologias, tornou-se mais pertinente tentar perceber que tipos de doentes dentro destes dois grandes grupos beneficiariam de cada tipo de intervenção e por isso se revisita o conceito dos fenótipos de diabetes e insuficiência cardíaca.

Este artigo resume a evidência existente sobre os fenótipos mais comuns na literatura relativamente a estas duas patologias, assim como se discute a importância e utilidade clínica da caracterização destes doentes de modo a estratificar o risco associado à presença em simultâneo de ambas as patologias.

Downloads

Não há dados estatísticos.

Referências

Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol. 1974;34:29-34. doi: 10.1016/0002-9149(74)90089-7.

He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001;161:996-1002. doi: 10.1001/archinte.161.7.996. P

Thrainsdottir IS, Aspelund T, Thorgeirsson G, Gudnason V, Hardarson T, Malmberg K, Sigurdsson G, Rydén L. The association between glucose abnormalities and heart failure in the population-based Reykjavik study. Diabetes Care. 2005;28:612-6. doi: 10.2337/diacare.28.3.612.

McAllister DA, Read SH, Kerssens J, Livingstone S, McGurnaghan S, Jhund P, et al. Incidence of Hospitalization for Heart Failure and Case-Fatality Among 3.25 Million People With and Without Diabetes Mellitus. Circulation. 2018;138:2774-86. doi: 10.1161/CIRCULATIONAHA.118.034986

Ohkuma T, Komorita Y, Peters SA, Woodward M. Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals. Diabetologia. 2019;62:1550-60. doi: 10.1007/s00125-019-4926-x.

Pop-Busui R, Januzzi JL, Bruemmer D, Butalia S, Green JB, Horton WB, et al. Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association. Diabetes Care. 2022;45:1670-90. doi: 10.2337/dci22-0014.

Ceriello A, Catrinoiu D, Chandramouli C, Cosentino F, Dombrowsky AC, Itzhak B, et al. Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management. Cardiovasc Diabetol. 2021;20:218. doi: 10.1186/s12933-021-01408-1.

Bugger H, Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2014;57:660-71. doi: 10.1007/s00125-014-3171-6.

Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6:361-9. doi: 10.1016/S2213-8587(18)30051-2.

Gouda P, Zheng S, Peters T, Fudim M, Randhawa VK, Ezekowitz J, et al. Clinical Phenotypes in Patients With Type 2 Diabetes Mellitus: Characteristics, Cardiovascular Outcomes and Treatment Strategies. Curr Heart Fail Rep. 2021;18:253-63. doi: 10.1007/s11897-021-00527-w.

Kahkoska AR, Geybels MS, Klein KR, Kreiner FF, Marx N, Nauck MA, et al. Validation of distinct type 2 diabetes clusters and their association with diabetes complications in the DEVOTE, LEADER and SUSTAIN-6 cardiovascular outcomes trials. Diabetes Obes Metab. 2020;22:1537-47. doi: 10.1111/ dom.14063.

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599-726. doi: 10.1093/eurheartj/ ehab368.

Lejeune S, Roy C, Slimani A, Pasquet A, Vancraeynest D, Vanoverschelde JL, et al. Diabetic phenotype and prognosis of patients with heart failure and preserved ejection fraction in a real life cohort. Cardiovasc Diabetol. 2021;20:48. doi: 10.1186/s12933-021-01242-5.

Bozkurt B, Coats A, Tsutsui H. Universal Definition and Classification of Heart Failure. J Card Fail. 2021:S1071-9164(21)00050-6. doi: 10.1016/j. cardfail.2021.01.022.

Pandey A, Vaduganathan M, Patel KV, Ayers C, Ballantyne CM, Kosiborod MN, et al. Biomarker-Based Risk Prediction of Incident Heart Failure in Pre- -Diabetes and Diabetes. JACC Heart Fail. 2021;9:215-23. doi: 10.1016/j. jchf.2020.10.013.

Pandey A, Vaduganathan M, Patel KV, Ayers C, Ballantyne CM, Kosiborod MN, et al. Biomarker-Based Risk Prediction of Incident Heart Failure in Pre- -Diabetes and Diabetes. JACC Heart Fail. 2021;9:215-23. doi: 10.1016/j. jchf.2020.10.013.

Downloads

Publicado

03-03-2023

Como Citar

1.
Almeida Ramalho S. Fenótipos de Diabetes Mellitus e Insuficiência Cardíaca. RPMI [Internet]. 3 de Março de 2023 [citado 17 de Novembro de 2024];30(1):12-5. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1600

Edição

Secção

Artigo de Opinião