Lípidos e imunidade

Autores

  • José Manuel dos Santos Pereira de Moura Assistente Hospitalar Graduado de Medicina Interna, Serviço de Medicina 2, Hospitais da Universidade

Palavras-chave:

Inflamação, infecção, ácidos gordos polinsaturados (PUFA), eicosanóides, aterosclerose

Resumo

Diversos dados epidemiológicos sugerem
uma relação entre a aterosclerose e os processos infecciosos e inflamatórios crónicos. Significativas alterações no metabolismo proteico e lipídico acompanham as reacções infecciosas
e inflamatórias, constituindo a clássica resposta de fase aguda (RFA). A RFA pode perturbar
o metabolismo das lipoproteínas, traduzindo-se por alterações qualitativas e quantitativas
destas partículas plasmáticas.
Por sua vez, os lípidos podem, através do seu metabolismo, influenciar a síntese de diversos
e importantes mediadores inflamatórios, os eicosanóides.
Com base nestas constatações, tem-se procurado alterar favoravelmente o curso de várias
doenças infecciosas e inflamatórias através da
manipulação dietética, particularmente a nível da composição em ácidos gordos polinsaturados.

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Referências

Robinson D, Section 2, Evaluation, signs and symptoms-Inflamation. In : Klippel J, Dieppe P, Rheumatology, Mosby, London Edinburgh,

New York, Philadelphia, St Louis, Sydney, Toronto, 2000, 1.1.1-1.11.8

German J, Dillard C, Whelan J. Biological effects of dietary arachidonic acid. J. Nutrition 1995; 126:1076S-1080S.

Watkins S, German J, shoenfeld Y Gershwin M. II Pathogenic Immune Mechanism of Atherosclerosis – Lipids and Immunity. In: Shoenfeld Y, Harats D, Wick G. Atherosclerosis and Autoimmunity. Elsevier Amsterdam, Lausanne, New York, Oxford, Shannon, Singapore,

Tokyo.2001;29-114

Khovidhunkit W, Memon R, Feingold K et al. Infection and inflammation-induced proatherogenic changes of lipoproteins. The Journal

of Infectious Diseases. 2000;181 ( Suppl 3 ): S462-72

Ilowite N. Hyperlipidemia and the rheumatic diseases. Current Opinion in Rheumatology. 1996; 8:455-458.

Ilowite N. Premature atherosclerosis in systemic lupus erythematosus. J Rheumatol 2000; 27:Suppl 58: 15-19

Bruce I, Urowitz M, Gladman D, et al. Natural history of hypercholesterolemia in systemic lupus erythematosus. J Rheumatol 1999;26:2137-

Bruce I, Gladman D, Urowitz M. Detection and modification of risk factors for coronary artery disease in patients with systemic lupus

erythematosus: A quality improvement study.Clinical and Experimental Rheumatology 1998; 16:435-440.

Hellerstein M, Grunfeld C, Wu K et al. Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. J Clin Endocrinol Metab 1993; 76:559-565.

Walzem R, Watkins S, Frankel E, et al. Older plasma lipoproteins are more susceptible to oxidation: A linking mechanism for the lipid and

oxidation theories of atherosclerotic cardiovascular disease. Proc. Natl. Acad. Sci. USA 1995; 92: 7460-7464.

Chait A, Brazg R, Tribble D, et al. Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B. The American Journal of Medicine 1993;94: 350-356

Memon A, Staprans I, Noor M, et al. Infection and inflammation induce LDL Oxidation in vivo. Arteriosclerosis, Thrombosis and Vascular

Biology 2000;20 (6):1536-1542

Marathe S, Schissel S, Yellini M, et al. Human vascular endothelial cells are a rich and regulatable source of scretory sphingomyelinase.

The Journal of Biological Chemistry 1998; 273 (7): 4081-4088

Memon R, Holleran M, Moser H,et al. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Arteriosclerosis, Thrombosisand Vascular Biology 1998; 18 (8): 1257-1265

Schissel S, Jiang X, Tweedl-Hardman J, et al. Secretory sphingomyelinase gene, can hydrolyse atherogenic lipoproteins at neutral ph. The

Journal of Biological Chemistry 1998; 273 (5): 2738-2746

Schissel S, Keesler G, Schuchman E, et al. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two

products of acid sphingomyelinase gene. The Journal of Biological Chemistry 1998;273 (29);18250-18259

Schissel S, Schuchman E, Williams K, et al. Zn2+ stimulated sphingomyelinase is secreted by many cell types and is a product of the

acid sphingomyelinase gene. The Journal of Biological Chemistry1996; 271 (31): 18431-18436

Goldkorn T, George J, Lavrentiadou S, et al. II Pathogenic Immune Mechanism of Atherosclerosis – Ceramide pathway and apoptosis in

autoimmunity and atherosclerosis. In: Shoenfeld Y, Harats D, Wick G. Atherosclerosis and Autoimmunity. Elsevier Amsterdam, Lausanne, New York, Oxford, Shannon, Singapore, Tokyo. 2001;29-114

Schissel S, Tweedl-Hardman J, Rapp J, et al. Rabbit aorta and human atherosclerotic lesions hydrolize the sphingomyelin of retained low-density lipoprotein. J. Clin. Invest.1996; 98(6):1455-1464

Borba E, Bonfa E, Vinagre C, et al.Chylomicron metabolism is markedly altered in systemic lupus erythematosus. Arthritis & Rheumatism 2000; 43 (5):1033-1040

Ly H, Francone O, Fielding C, et al. Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels

in Syrian hamsters. Journal of Lipid Research 1995; 36:1254-1263

Hardardóttir I, Moser A, Fuller J, et al. Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of

cholesteryl ester protein in Syrian hamsters. The Journal of ClinicalInvestigation 1996; 97(11): 2585-2592

Lamping N, Dettmer R, Schroder N, et al. LPS-binding protein mice from septic shock caused by LPS or Gram-negative bacteria. J. Clin.

Invest.1998; 101(10): 2065-2071

Grunfeld C, Marshall M, Shigenaga J, et al. Lipoproteins inhibit macrophage activation by lipoteichoic acid. Journal of Lipid Research

; 40: 245-252

Feingold K, Hardardottir I, Memon R, et al. Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoprotein in Syrian hamsters. Journal of Lipid Research 1993; 34: 2147-2158

Simopoulos A. Essential fatty acids in healyh and chronic disease. Am J Clin Nutr 1999; 70(suppl): 560S-569S

Woods K, Thien K, Abramson J. Dietary marine fatty acids (fish oil) for asthma. The cochrane database of systemic reviews. The Cochrane

Library, Copyright 2001; Volume (Issue 3) (no page)

Linos A, Kaklamani V, Kaklamani E, et al. Dietary factors in relation to rheumatoid arthritis: a role for olive oil and cooked vegetables? Am

J Clin Nutr 1999; 70:1077-1082

Hall A, Parbtani A, Clark W, et al. Abrogation of MRL/Ipr lupus nephritis by dietary flaxseed. American Journal of Kidney Diseases 1993;

(2):326-332

Clark W, Parbtani A, Huff M, et al. Flaxseed : A potential treatment for lupus nephritis. Kidney International 1995; 48:475-480

Belch J, Hill A. Evening primrose oil and borage oil in rheumatoid conditions. Am J Clin Nutr 2000; 71 (suppl): 352S-356S

Kremer J, Lawrence D, Jubiz W, et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis and

Rheumatism 1999; 33(6):810-820

James M, Gibson R, Cleland L. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000; 71(suppl): 343S-348S

Lauritsen K, Laursen L, Bukhave K. Use of colonic eicosanoid concentration as predictors of relapse in ulcerative colitis: double blind

placebo controlled study on sulphalazine maintenance treatment. Gut1988; 29: 1316-1321

Esteve M, Navarro E, Klasseen J, et al. Plasma and mucosal fatty acid pattern in colectomized ulcerative colitis patients. Digestive Diseases

and Sciences 1998; 43(5):1071-1078

Arend W, Dayer J. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor a in rheumatoid arthritis. Arthritis and Rheumatism 1995; 38(2): 151-160

Caughey G, Mantzioris E, Gibson R, et al. The effect on human tumor necrosis factor a and interleukin 1b production of diets enriched in n.3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 1996; 63:116-122

Endres S, Ghorbani R, Kelley V, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. The New England Journal of Medicine 1989; 320 (5):265-271

Hughes D, Pinder A. n-3 Polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. Am J Clin Nutr 2000;

(suppl):357S-360S

Hughes D, Southon S, Pinder A. (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. J. Nutr. 1996; 126:603-610

Fernandes G, Bysani C, Venkatraman J. Increased TGF-b and decreased oncogene expression by w-3 fatty acids in the spleen delays onset

of autoimmune disease in B/W mice. Journal of Immunology 1994;152:5979-5987

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Publicado

31-03-2003

Como Citar

1.
dos Santos Pereira de Moura JM. Lípidos e imunidade. RPMI [Internet]. 31 de Março de 2003 [citado 24 de Abril de 2024];10(1):23-8. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1783

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