Lípidos e imunidade
Keywords:
Inflammation, infection, polyunsaturated fatty acids, eicosanoids, atherosclerosisAbstract
Epidemiologic data suggest a link between
atherosclerosis and chronic infections and inflammatory conditions. During infection and
inflammation, a wide range of alterations in metabolism occur. These are part of the body´s reaction known as the acute phase response (APR). Infection and inflammation can also perturb lipoprotein metabolism and produce a wide
variety of changes in the plasma concentrations of lipids and lipoproteins.
Eicosanoids are a group of oxygenated fatty
acids with diverse and potent biological activity, produced from the fatty acids. The variety
of eicosanoids products and their correspondingly diverse physiological effects have been well characterized, and probably represent the best-understood relationship between lipids and biological function. Consequently, attempts to
modulate the production of eicosanoids must
target either the enzyme activities responsible for synthesizing eicosanoids or the concentration of fatty acids substrate entering biological system through the diet.
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