Imunidade na Infeção pelo SARS-CoV-2: O que Sabemos

Autores

  • Cláudio Nunes Silva Unidade de Doenças Infeciosas Emergentes, Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal https://orcid.org/0000-0002-4694-1362
  • Filipa Ceia Unidade de Doenças Infeciosas Emergentes, Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal https://orcid.org/0000-0002-8382-750X
  • Margarida Tavares Unidade de Doenças Infeciosas Emergentes, Serviço de Doenças Infeciosas, Centro Hospitalar Universitário de São João, Porto, Portugal; EPIUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal https://orcid.org/0000-0003-4518-2197

DOI:

https://doi.org/10.24950/rspmi/COVID19/CHUSJ/S/2020

Palavras-chave:

Anticorpos Neutralizantes, Betacoronavírus, COVID-19, Imunidade Celular, Infecções por Coronavírus/imunologia, Pandemia

Resumo

Sobre a pandemia provocada pelo SARS-CoV-2, muito conhecimento tem sido produzido e dado a conhecer, mas muitas dúvidas permanecem por esclarecer acerca da sua interação com o ser humano, nomeadamente sobre se a resposta imune contra este novo coronavírus humano é protetora a longo prazo e qual a possibilidade de re-infeção. A COVID-19 pode assumir diferentes espetros clínicos, desde infeções assintomáticas até formas graves da doença, que resultam da inter-relação entre a patogenicidade própria do vírus e a resposta imune do hospedeiro. Esta revisão foca-se na imunologia da infeção, reunindo não só o conhecimento acumulado com as epidemias associadas ao SARS-CoV e MERS-CoV, mas também o que já se sabe sobre o SARS-CoV-2. Este conhecimento é fundamental e tem implicações quer para o controlo e prevenção da doença quer para o seu diagnóstico e tratamento.

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21-12-2021

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Nunes Silva C, Ceia F, Tavares M. Imunidade na Infeção pelo SARS-CoV-2: O que Sabemos. RPMI [Internet]. 21 de Dezembro de 2021 [citado 5 de Julho de 2022];:60-7. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/225

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