SARS-CoV-2 Immune Response: An Overview
DOI:
https://doi.org/10.24950/rspmi/COVID19/CHUSJ/S/2020Keywords:
Antibodies, Neutralizing, Betacoronavirus, Coronavirus Infections/immunology, COVID-19, Immunity, Cellular, Pandemics, Immunology, Cell-medianted Immunity, Humoral Immune Response, Innate Immunity, Neutralizing AntibodiesAbstract
Despite all that is recognized so far on the ongoing SARS- CoV-2 pandemic, many questions remain to be answered, particularly in what concerns pathogen interaction with the human host and whether or not the acquired immune response is protective against re-infection in the long-term. The spectrum of COVID-19 ranges from asymptomatic infections to progressive critical states, a direct upshot from the complex interplay between virus pathogenicity and host antiviral defense. This review focuses on the immunologic response and disarrangements underlying the SARS-CoV-2 pathophysiology, gathering the information not only from the lessons learnt from SARS and MERS-CoV epidemics but also from what is already known about SARS-CoV-2 to date. This knowledge is paramount from the standpoint of disease prevention and control as well as di- agnostic pipeline and treatment.
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