Revisitando as Síndromas Hipertérmicas Fármaco-Induzidas
DOI:
https://doi.org/10.24950/rspmi/revisao/282/3/2018Palavras-chave:
Febre, Hipertermia, Preparações FarmacêuticasResumo
A febre é uma causa frequente de recorrência aos Serviços de Urgência (SU) mas muitas vezes não está associada a infecção. Existem vários fármacos que, de diferente forma, podem condicionar o sistema de termorregulação causando um estado hipercatabólico que pode ser fatal se não for reconhecido de forma atempada. Existem cinco síndromas hipertérmicas fármaco-induzidas major: (1) síndroma maligna dos neurolépticos, (2) síndromas erotoninérgica, (3) síndroma anticolinérgica, (4) síndroma simpaticomimética e a (5) síndroma da hipertermia maligna. Os autores têm como objectivo a revisão destas síndromas hipertérmicas fármaco-induzidas, o seu diagnóstico diferencial, tratamentos possíveis, bem como os efeitos deletérios de hipertermia sustentada, evidenciando as suas consequências neurológicas. A hipertermia fármaco-induzida é um diagnóstico muitas vezes esquecido aquando a abordagem de quadros febris e cujo tratamento inclui descontinuação do fármaco responsável, medidas de suporte e em alguns casos terapêutica farmacológica adequada.
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