Diabetes and cancer: a short review for internists
Keywords:
diabetes, cancer, insulin, insulin analogues, sulfonylureas, metforminAbstract
The risk of developing a range of cancers is moderately increased in type 1 and type 2 diabetes. Obesity, insulin resistance,
hyperinsulinemia, and diabetes therapy with insulin, insulin
analogues and sulfonylureas may be responsible for this fact.
Metformin seems to have a protective effect. We examined all
these aspects, and believe that the current aetiopathogenic link
among diabetes, diabetes treatment and cancer is tenuous, further
studies are necessary
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References
Smith U, Gale EAM. Does diabetes therapie influence the risk of cancer? Diabetologia 2009; 52: 1699-1708.
Zendehdel K, Nyrén O, Östenson C-G, Adami H-O, Ekbom A, Ye W. Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J Natl Cancer Inst 2003; 95: 1797-1800.
Shu X, Ji J, Li X, Sundquist J, Sundquist K, Hemminki K. Cancer risk among patients hospitalized for type 1 diabetes mellitus: a population-based cohort study in Sweden. Diabet Med 2010; 27: 791-797.
Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate and pancreas. Gastroenterology 2007; 132: 2208-2225.
Giovannucci E, Harlan DM, Archer MC, et al. Diabetes and cancer: a consensus report. CA Cancer J Clin 2010; 60: 207-221.
Draznin B. Mitogenic action of insulin: friend, foe or “frenemy”? Diabetologia 2010; 53: 229-233.
Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 2009; 52: 1732-1744.
Jonasson JM, Ljung R, Talbäck M, Haglund B, Gudbjörnsdòttir S, Steineck G. Insulin glargine use and short-term incidence of malignancies: a population-based follow-up study in Sweden. Diabetologia 2009; 52: 1745-1754.
Currie CJ, Poole CD, Gale EAM. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009; 52: 1766-1777.
Colhoun HM, SDRN Epidemiology group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia 2009; 52: 1755-1765.
Müssig K, Staiger H, Kantartzis K, Fritsche A, Kanz L, Häring H-U. Diabetes, Insulin, Insulinanaloga und Karzinome. Dtsch Med Wochenschr
; 135: 924-929.
Home PD, Langarenne P. Combined randomized controlled trial experience of malignancies in studies using insulin glargine. Diabetologia 2009; 52; 2499-2506.
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