Simultaneous discoveries and the Medicine of the 20th century (part III) – The first tuberculostatics

Authors

  • A. J. Barros Veloso Médico

Keywords:

tuberculosis, estreptomycin, PAS, isoniazid, Waksman, Schatz, Lehmann, simultaneous discoveries

Abstract

The author describes with great detail the chain of events that
led to the discovery of streptomycin, PAS and isoniazid between
1944 and 1952 and to the posterior changes in the area of
tuberculosis.

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References

Shatz A, Bugie E, Wasksman S. Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc Soc Exper Biol.& Med 1944;55:66-69.

Feldman WH, Hinshaw HC. Effects of streptomycin on experimental tuberculosis in guinea pigs. Proc Staff Meet Mayo Clin. 1944;19: 593-599.

Hinshaw HC, Feldman WH. Streptomycin in the treatment of clinical tuberculosis. Proc Meet Mayo Clinic 1945; 20: 313-318.

Hinshaw HC, Feldman WH, Preutz KH.Streptomycin in the treatment of clinical tuberculosis. Am Rev Tub 1946; 54: 191-203.

Streptomycin treatment of tuberculosis. A Medical Research Council Investigation. BMJ 1948; 2; 769-782.

Tapia M e col. Nuestra experiencia sobre el tratamiento de la tuberculosis por la estreptomicina. (1948). Liv Luso-Espanhola, Lª

Tapia M e col. Los resultados del tratamiento de la tuberculosis pulmonar con estreptomicina, basados en el estúdio de 200 casos. Estatística de 1947 da Estância Sanatorial do Caramulo, pg. 35-56.

Lehhmann, J. Paraminosalicylic acid in the treatment of tuberculosis. Lancet, Jan.5, 1946: 15-16

Treatment of tuberculosis with PAS and streptomycin: preliminary report. BMJ 31 Dec.1949:1521.

Hinshaw HC, McDermott W. Thiosemicarbazone therapy of tuberculosis in humans. Am Rev Tuberc 1950; 61:145-157

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Fanu J.L. The rise and fall of modern medicine (1999). Little, Brown and Company.

Hill AB. Memories of the British Streptomycin Trial in Tuberculosis. Controlled Clinical Trials 1990; 11: 77-79.

Iseman MD. Tuberculosis Therapy. Eur Resp J 2002; 20: 87S-94S.

Murray JF. A Century of Tuberculosis. Am J Crit Care Med. 2004; 169: 1181-1186.

Ryan F. Tuberculosis: The Greatest Story Never Told (1992). Swift Publishers.

Wallgren A. Presentation Speech. Nobel Price of Medicine or Physiology, 1952.

Waksman S. Streptomycin: background, isolation, properties and utilization. Nobel Lecture, Dec. 1952.

Yoshioka A. Use of randomisation in the Medical Research Council’s clinical trial of streptomycin in pulmonary tuberculosis in 1940s. BMJ 1998; 317: 1220-1223.

Additional Files

Published

2008-03-31

How to Cite

1.
Barros Veloso AJ. Simultaneous discoveries and the Medicine of the 20th century (part III) – The first tuberculostatics. RPMI [Internet]. 2008 Mar. 31 [cited 2024 Sep. 7];15(1):68-76. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1453

Issue

Section

História da Medicina