Left supraclavicular lymph node enlargement as the initial manifestation of metastatic prostate cancer
Keywords:
Prostate cancer, metastasis, supraclavicular nodesAbstract
The involvement of supraclavicular lymph nodes in metastatic
prostate cancer is usually considered uncommon, and is extremely rare as the initial manifestation of the disease. We describe
the clinical case of a 77 year-old man, who presented with left
supraclavicular lymphadenopathy for 3 months, with no other
symptoms. The investigation led to the diagnosis of prostate cancer with metastatic ganglionar dissemination. Hormonal therapy
induced an almost complete regression of all lymphadenopathies
and a reduction of PSA from 4642 ng/dl to 0.1 ng/dl. Prostate
cancer must always be considered in the differential diagnosis of
supraclavicular lymphadenopathies in patients with more than 45
year-old, even in the absence of prostatic symptoms. The recent
suggestion that this presentation could be more frequent than
traditionally reported is discussed.
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References
Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh t. Metastatic patterns of prostate cancer: correlation between sites and number of organs involved. Cancer 1984; 54:3078 – 3084.
Wang HJ, Chiang PH, Peng JP, Yu TJ. Presentation of prostate carcinoma with cervical lymphadenopathy: Report of three cases. Chang Gung Med J 2004; 27: 840 – 844.
Chitale SV, Harry L, Gaches CGC,Ball RY. Presentation of prostatic adenocarcinoma with cervical lymphadenopathy . Two case reports and review of the literature. Otolaryngol Head Neck Surg 2001; 125: 431-432.
Ahamed SH, Agarwal AK, Raju PP. Metastatic prostate carcinoma presenting as supraclavicular lymphadenopathy – is it unusual? Ann R Coll Surg Engl 2006; 88 (6): W4 -54.
Chau I, Kelleher MT, Cunningham D et al. Rapid access multidisciplinary lymph node diagnostic clinic: analysis of 550 patients. Br J Cancer 2003; 88: 354.
Morgenstern L. The Virchow – Troisier node: a historical note. Am J Surg 1979; 138: 703?
Cozzi PJ and Schmidt GA. Airway compression by a mediastinal mass. Chest 1994;106:1237-1238.
Butler J, Howe CD, Johnson DE. Enlargement of supraclavicular lymph nodes as the initial sign of prostatic carcinoma. Cancer May 1971;13(6): 1055-1063
Saeter G, Fosso SD, Ous S, Blom GP, Kaalhus O. Carcinoma of the prostate with soft tissue or non –regional lymphatic metatases at the time of diagnosis : a review of 47 cases. Br J Urol 1984; 56: 385 – 390.
Cho KR, Epstein J. Metastatic prostatic carcinoma to supradiaphragmatic lymph nodes: a clinicopathologic and immunohistochemical study. Am J Surg Path 1987; 11: 457-463.
Sternberg CN. What’s new in the treatment of advanced prostate cancer? Eur J Cancer 2003; 39: 136-146.
Sciarra A, Cardi A, Salvatori G, D’Eramo G, Mariotti G, Silvério F. Wich patients with prostate cancer are actually candidates for hormone therapy? Int Braz J Urol 2004; 30: 455-465
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