Cerebral and spinal cord toxoplasmosis: a clinical case report
Keywords:
AIDS, Toxoplasma gondii, Cerebral and Spinal cord MRI, PCR for Toxoplasma gondii, therapeutic testAbstract
The authors describe a case of cerebral and spinal cord Toxoplasmosis as the first manifestation of AIDS, in a patient who’s
HIV infection was unknown.
In this context, opportunistic infections usually appear, when the
number of TCD4 lymphocytes are under 200 cells/μL.
Toxoplasmosis is the most frequent cause of focal cerebral injuries in patients infected with HIV; however, Spinal cord injury due
to Toxoplasma gondii is very unusual. We have only found a total
of 16 published cases in the medical literature since 1988.
Given the fact of the rarity of spinal cord injury by Toxoplasmosis,
some theoretical considerations are made, focused on the clinical
management of the Myelopathy in HIV patients.
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References
Rivas González P, Fernandez Guerrero ML. Central Nervous System infections in HIV patients in the era of High activity antiretroviral treatment. Rev Clin Esp 2005; 205 (6): 278-282.
Moulignier A. HIV and the Central Nervous System. Rev Neurol (Paris) 2006 ; 162 (1): 22-42.
Portegies P, Solod L, Cinque P. Guidelines for the diagnosis and manegement of neurological complications of HIV infection. Eur J Neurol 2004 ; 11 (5): 297-304.
Provenzale JM et al. Brain and Spine findings in AIDS patients. Radiol Clinic North Am 1997; 35 (5); 1127-1166.
Vyas R e Ebright JR. Toxoplasmosis of the spinal cord in a patient with AIDS: case report and review. Clin Inf Diseases 1996; 23: 1061-1065.
Maciel E et al. Toxoplasma gondii myelitis in a patient with Adult T-cell Leukemia-Lymphoma. Arq Neuropsiquiatr 2000; 58(4): 1107-1109.
Ghezzi A et al. Differential diagnosis of acute myelopathies. Neurol Sci 2001; 22: S60-S64.
Thurnher MM et al. MRI of infections and neoplasms of Spine and Spinal cord in 55 patients with AIDS. Neuroradiology 2000; 42(8): 551-563.
Sotolongo Pedro, Carrillo Pedro, Carrillo Carlos. Enfermedades de la medula espinal en el curso de la infección por el virus de la inmunodeficiencia humana. Rev Cubana Med Dic 2003; 4(6) : 0-0.~
Offiah CE, Turnbull IW. The Imaging appearances of intracranial CNS infections in adult HIV and AIDS patients. Clin Radiol 2006 ; 61 (5): 393-401.
Wilson BG. CT assessment of CNS complications of AIDS; Radiol Technol 2002 ; 73 (5): 424-437.
Smego RA Jr, Orlovic D, Wadula J. An Algorithm approach to intracranial mass lesion in HIV/AIDS. Int J STD AIDS, 2006 ; 17 (4): 271-276.
Lorberboym M, Wallach F, Estok L. Thalium-201 retention in focal intracranial lesions for differential diagnosis of primary lymphoma and non-malignant lesions in AIDS patients. J Nucl Med 1998; 39 (8): 1366-1369.
Willis, Monte S. et al. Toxoplasma Infection: making the best use of Laboratory tests; Infect Med 2002; 19 (11): 522-532.
Montoya, JG; Laboratory diagnosis of Toxoplasma gondii infection and Toxoplasmosis; J Infect Dis (United States) 2002; 185 (1): S73-S82.
Colombo FA, Vidal JE, Penalva de Oliveira AC. Diagnosis of cerebral Toxoplasmosis in AIDS patients in Brazil: importance of molecular and imunological methods using peripheral blood samples. J Clin Microbiol 2005; 43 (10): 5044-5047
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