Flutamide induced acute cholestatic hepatitis

Authors

  • J. Presa Assistente Hospitalar de Medicina Interna, Serviço de Medicina do Centro Hospitalar de Vila Real-Peso da Régua, Portugal
  • E. Marcos Interna Complementar de Clínica Geral, Serviço de Medicina do Centro Hospitalar de Vila Real-Peso da Régua, Portugal
  • T. Faria Director do Serviço de Medicina Interna, Serviço de Medicina do Centro Hospitalar de Vila Real-Peso da Régua, Portugal

Keywords:

prostate, cholestasis, flutamide

Abstract

Flutamide is an antiandrogenic drug used in
prostatic cancer therapeutics, with very known hepatic side effects.
The case report a patients treated with flutamide, who developed a cholestatic hepatitis.

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References

Mendoza-Valdes A, Ocampo-del-Carpio O, De-la-Garza J. The treatment of advanced prostatic carcinoma with total androgenic blockade

using orchidectomy and flutamide: Experience at National Cancer Institute in Mexico. Semin Oncol 1991;18:19-20.

Spyros P Dourakis, Alexandra A Alexopoulov, Stephanos J Hadziyannis. Fulminant hepatitis after flutamide treatment. J Hepatol 1994; 20:

-353.

Gomez JL, Dupont A, Cusan L, Tremblay M, Suburu R, Lemay M, Labrie F. Incidence of liver toxicity associated with the use of flutamide

in prostate cancer patient. Am J Med 1992;92:465-470.

Crownover RL, Holland J, Chen A, Krieg R, Young BK, Roach M et al. Flutamide-induced liver toxicity including fatal hepatic necrosis.

Int J Radiat Oncol Biol Phys 1996;34(4):911-915.

Moghetti P, Castello R, Negri C, Tosi F, Magnani CM, Fontanarosa MC et al. Flutamide in the treatment of hirsutism: long-term clinical

effects, endocrine changes and androgen receptor behavior. Fertil Steril 1995;64(3):511-517.

Moller S, Iversen P, Franzmann MB: Flutamide-induced liver failure. J Hepatol 1990;10:346-349.

Corkery JC, Bihrle W, McCaffrey JÁ, Whitcomb FF, Levy C, Ellis R. Flutamide-related fulminant hepatic failure. J Clin Gastroenterol

;13:364-365.

Wysowski DK, Freiman JP, Tourtelot JB, Marshall LH. Fatal and nonfatal hepatotoxicity associated with flutamide. Ann Intern Med

;118(11):860-864.

Rosman AS, Frissora-Rodeo C, Marshall AT, Reiter BP, Paronetto F. Cholestatic Hepatitis Following Flutamide. Dig Dis Scienc 1993;38(9):1756-1759.

Hart W, Stricker BH. Flutamide and hepatitis (letter). Ann Intern Med 1989;110:943-944

Scheuer PJ, Lefkowitch JH. Liver Biopsy Interpretation, 6th Edn. WB Saunders 2000; Ch.9: 142-143.

Caballeria E, Aragó JV, Sanchis A. Hepatotoxicidad por flutamida. Med Clin (Barc) 1994;102(11):434

Additional Files

Published

2004-12-31

How to Cite

1.
Presa J, Marcos E, Faria T. Flutamide induced acute cholestatic hepatitis. RPMI [Internet]. 2004 Dec. 31 [cited 2024 Dec. 18];11(4):195-6. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1767

Issue

Vol. 11 No. 4 (2004): Outubro/ Dezembro

Section

Case Reports

License

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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