Conjunctival Kaposi’s Sarcoma. An unusual AIDS presentation

Authors

  • Sofia Pinheiro Médica do Internato Complementar de Medicina Interna, Serviço de Medicina 2, Hospital dos Capuchos, Lisboa
  • Alexandra Horta Assistente Graduada de Medicina Interna, Serviço de Medicina 2, Hospital dos Capuchos, Lisboa.
  • Maria José Serra Chefe de Serviço de Medicina Interna, Serviço de Medicina 2, Hospital dos Capuchos, Lisboa.
  • Hélder Simões Assistente Eventual de Oftalmologia, Serviço de Oftalmologia do Hospital dos Capuchos, Lisboa
  • Nuno Ramos Assistente Eventual de Oftalmologia, Serviço de Oftalmologia do Hospital dos Capuchos, Lisboa
  • Manuela Carmona Assistente Graduada de Oftalmologia, Serviço de Oftalmologia do Hospital dos Capuchos, Lisboa
  • António Castro Director do Serviço 2 de Medicina Interna, Serviço de Medicina 2, Hospital dos Capuchos, Lisboa

Keywords:

AIDS, ocular Kaposi sarcoma, cidofovi

Abstract

Isolated ocular Kaposi’s Sarcoma appears in
0.3 to 5% of AIDS patients. However, AIDS patients with disseminated Kaposi’s Sarcoma have
a much higher incidence of ocular presentations (15-20%).
A clinical case-report of epidemic Kaposi’s Sarcoma with an ocular presentation is reported. Lipossomal daunorubicin and antiretroviral treatment were the first therapeutic options,
however as disease progressed under this regimen, alternative chemotherapy was started
in association with cidofovir.
This paper reviews ocular Kaposi’s Sarcoma
and discusses the role of cidofovir in the treatment of these tumours associated with human
herpes type 8 virus.

Downloads

Download data is not yet available.

References

Gottlieb MS, Schroff R, Schanker HM et al. Pneumocystis carinni pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med 1981; 305: 1425-1431.

Masur H, Michelis MA, Greene JB et al. An outbreak of comunity acquired Pneumocystis carinni pneumonia : initial manifestation of cellular immune dysfunction. N Engl J Med 1981; 305: 1431-1438.

Palella FJ, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced Human Immunodeficiency

Virus infection. N Engl J Med 1998; 338: 853-860.

Haverkos H, Drotman D, Morgan M. Prevalence of Kaposi’s Sarcoma among patients with AIDS [letter]. N Engl J Med 1985; 312: 1518.

The swiss HIV cohort study. AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy. JAMA 1999;

(23): 2220-2226.

Jabs D, Green W, Fox R, Polk F, Bartlett J. Ocular manifestations of acquired immune deficiency syndrome. Ophthalmol 1989; 96 (7): 1092-

Holland G, Pepose J, Pettit T, Gottlieb M, Yee R, Foos R. Acquired immune deficiency syndrome. Ocular manifestations. Ophthalmol

; 90 (8): 859-873.

Corti M, Solari R, Carolis L, Corraro R. Compromiso ocular en el Sarcoma de Kaposi asociado con el SIDA. Enferm Infecc Microbiol Clin

; 19: 3-6.

Palestine AG, Rodrigues MM, Macher AM et al. Ophthalmic involvement in acquired immune deficiency syndrome. Ophthalmol 1984; 91

(9): 1092-1099.

Shuler J, Holland G, Miles S, Miller B, Grossman I. Kaposi Sarcoma of the conjuntiva and eyelids associated with the acquired immune

deficiency syndrome. Arch Ophthalmol 1989; 107: 858-862.

Cunningham E, Margolis T. Ocular manifestations of HIV infection. N Engl J Med 1998; 339: 236-244.

Collaço L, Gonçalves M, Gomes L, Miranda R. Orbital Kaposi’s Sarcoma in acquired immune deficiency syndrome. Eur J Ophthalmol

; 10 (1): 88-90.

Kurumety U, Lustbader J. Kaposi’s Sarcoma of the bulbar conjuntiva as an initial clinical manifestation of acquired immune deficiency syndrome [letter]. Arch Ophthalmol 1995; 113: 978.

Murray N, McCluskey P, Wakefield D, Beaumont P. Isolated bulbar conjuntival Kaposi’s Sarcoma. Aust N Z J Ophthalmol 1994; 22 (1):

-82.

Kaimbo K. Le sarcome de Kaposi a localisation oculaire au Zaire. BullSoc Belge Ophthalmol 1994 ; 254 : 117-121.

Dugel P, Gill P, Frangieh G, Rao N. Treatment of ocular adnexal Kaposi’s Sarcoma in acquired immune deficiency syndrome. Ophthalmol 1992; 99 (7): 1127-1132.

Dugel P, Gill P, Frangieh G, Rao N. Ocular adnexal Kaposi’s Sarcoma in acquired immune deficiency syndrome. Am J Ophthalmol 1990;

: 500-503.

Dupont C, Vasseur E, Beauchet A et al. Long-term efficacy on Kaposi’sSarcoma of highly active antiretroviral therapy in a cohort of HIV-positive patients. AIDS 2000; 14 (8): 987-993.

Antman K, Chang Y. Kaposi’s Sarcoma. N Engl J Med 2000; 342: 1027-1038.

Gill PS, Wernz J, Scadden DT et al. Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomicin, and vincristine in AIDS-related Kaposi’s Sarcoma. J Clin Oncol 1996; 14: 2353-2364.

Kedes D, Ganem D. Sensitivity of Kaposi’s Sarcoma associated herpes vírus replication to antiviral drugs. J Clin Invest 1997; 99 (9): 2082-

Martin D, Kuppermann B, Wolitz R, Palestine A, Hong Li, Robinson C. Oral ganciclovir for patients with Cytomegalovirus retinitis treated

with a ganciclovir implant. N Engl J Med 1999; 340: 1063-1070.

Robles R, Lugo D, Gee L, Jacobson M. Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of

previously diagnosed Kaposi Sarcoma in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20 (1): 34-38.

Mazzia R, Parisia SG, Sarmatib L et al. Efficacy of cidofovir on human herpesvirus 8 viraemia and Kaposi’s Sarcoma progression in two

patients with AIDS. AIDS 2001; 15: 2061-2062.

Additional Files

Published

2003-03-31

How to Cite

1.
Pinheiro S, Horta A, Serra MJ, Simões H, Ramos N, Carmona M, Castro A. Conjunctival Kaposi’s Sarcoma. An unusual AIDS presentation. RPMI [Internet]. 2003 Mar. 31 [cited 2024 Dec. 18];10(1):45-8. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1787

Issue

Vol. 10 No. 1 (2003): Janeiro/ Março

Section

Case Reports

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2023 Medicina Interna

Open Access

Most read articles by the same author(s)