Paraneoplastic Hypercoagulability – a clinical case with a rapid fatal evolution
Keywords:
Paraneoplastic hypercoagulability, disseminated intravascular coagulation, non-bacterial thrombotic endocarditis, thrombosis, embolisAbstract
The authors present a case of paraneoplastic
hypercoagulability that occurred as the first
manifestation of neoplasia. A variable and
rapidly fatal clinical course occurred and the
neoplasia was only clearly identified at autopsy.
The article includes some general theoretical considerations on the physiopathological
mechanisms possibly involved in the origin of
this type of paraneoplastic disorder, its possible
clinical manifestations and on some therapeutic proposals..
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References
Zidar DA. Angiogenesis and the crosstalk between coagulation factors and cancer. Osler Med J [serial online] 2000 Feb; 6. Available from:
URL: http://omj.med.jhu.edu.
Muh-Hwa Yang, Frank S. Fan, Po-min Chen et al. Venous gangrene in a patient with adenocarcinoma of the lung. Jpn J Clin Oncol 2000;
: 276-278.
Andrew I Schafer. Hemorrhagic disorders: mixed abnormalities. In: Lee Goldman, J.Claude Bennet, eds. Cecil Textbook of Medicine.
Philadelphia: W B Saunders, 2000; 1013-1016.
Habib G, Cohen P, Milandre L et al. Endocardite thrombotique abactérienne (endocardite marastique) - à propos d’un cas et de l’intérêt de
l’échographie transœphagienne. Arch Mal Coeur 1996; 89: 261-264.
Vassallo R, Remstein ED, Parisi JE, Huston J, Brown RD. Multiple cerebral infarctions from nonbacterial thrombotic endocarditis mimicking cerebral vasculitis. Mayo Clin Proc 1999;74:798-802.
Walsh-McMonagle D, Green D. Low-molecular-weight heparin in the management of Trousseau`s syndrome. Cancer 1997;80:649-655.
Koopman MM, Prandoni P, Piovella F et al. Treatment of venous thrombosis with intravenous heparin administered in the hospital as
compared with subcutanous low-molecular-weight heparin administered at home. N Engl J Med 1996; 334:682-687.
Sabah Sallah, Jim Y Wan, Nam P Nguyen, L R Hanrahan, George Sigounas. Disseminated intravascular coagulation in solid tumors:
clinical and pathologic study. Thromb Haemost 2001; 86: 828-833.
Woimant F, Moulinier L, Lecoz P, soria C, Mikol J, Cochan Priollet B, Haguenau M, pepin B. cerebral ischemic accidents and chronic disseminated intravascular coagulation of cancerous origin. Rev Neurol (Paris). 1988; 144: 120-124.
Douglas E Sutherland, hene C Weitz, Howard A Liebman. Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis and treatment. American Journal of Hematology 2003; 72: 43-52.
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