Whipple’s disease – a clinical case
Keywords:
Whipple’s disease, Tropheryma whippeliiAbstract
The authors present the case of a 61 year-old
patient, admitted with a clinical picture characterized
by digestive haemorrhage, and weight loss.
After investigation the diagnosis of Whipple disease
was made.
Antibiotic therapy with trimethoprim-sulfamethoxazole
was efficacious and was followed by a
rapid improvement of clinical and laboratory parameters
Downloads
References
Vital-Durand D, Lecomte C, Cathebras P, Rousset H, Godeau P. Whipple disease: Clinical review of 52 cases. Medicine (Baltimore)
; 76:170-184.
Jacques G.H. Gubler et al. Whipple Endocarditis without Overt Gastrointestinal Disease: Report of Four Cases. Ann. Intern. Med
; 131:112-116.
Mark C. Flemmer, MD and Ronald W. Flenner, MD Toward a New Understanding of Whipple’s Disease. Current Gastroenterology
Reports 2000, 2: 299-304.
Fleming JL, Wiesner RH, Shorter RG. Whipple disease: clinical, biochemical and histopathologic features and assessment of
treatment in 29 patients. Mayo Clin Proc 1988; 63:539-551.
Dobbins WO III. Is there an immune deficit in Whipple disease? Dig Dis Sci 1981; 26: 247-252.
Kent SP, Kirkpatrick PM. Whipple disease. Immunological and histochemical studies of eight cases. Arch Pathol Lab Med 1980;
: 544-547.
Groll A, Valberg LS, Simon JB et al. Immunological defect in Whipple’s disease. Gastroenterology; 1972; 63:943.
Kwitko AO, Shearman DJC, Mckenzie PE et al. Whipple’s disease: a case with circulating immune complexes. Gastroenterology 1980;
: 1318-1323.
Feurle GE, Dorken B, Schopf E et al. HLA B27 and defects in the T-cell system in Whipple’s disease. Eur J Clin Invest 1979; 9: 385-
Bai JC, Mota AH, Mauriño E et al. Class I and Class II antigens in a homogeneous Argentinean population with Whipple’s disease:
lack of association with HLA B27. Am J Gastroenter 1991; 8:992-994.
Cruz I, Ricardo JL, Moura Nunes, et al. Doença de Whipple associada a giardiase: coerente ou coincidente? Rev Soc Port Gastro
; 3:340-347.
Maliha Gm, Hepps KS, Maia DM et al. Whipple disease can mimic chronic AIDS enteropathy. Am J Gastroenterol 1991;
,1:79-81.
Trier JS. Whipple disease. Sleisenger and Fordtran. Gastrointestinal disease 1993; 2 (54):1118-1127.
Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple disease. N
Engl J Med 1992; 327: 293-301.
Raoult D, Birg ML, La Scola B et al. Cultivation of the bacillus of Whipple disease. N Engl J Med 2000; 342:620-625.
Feldman and Price G. Intestinal bleeding in patients with Whipple disease. Gastroenterology 1989; 96(4): 1207-1209.
Ewers HR, Gash J, Hamburger B et al. Endoscopic documentation of Whipple disease. Endoscopy 1976;8:160-171.
Guerin JM, Lebiez PE, Tibourtine O et al. Pseudo-maladie de Whipple au cours d’un syndrome d’ immunodéficit acquis. La
Presse Medicale 1987; 16: 781.
Sander S. Whipple disease associated with amyloidosis. Acta Patholo Microbiol Scand 1984; 61:530-536.
Kraunz RF. Whipple disease with cardiac and renal abnormalities. Arch Intern Med 1969; 123:701-706.
Ottaway CA, Warren RE, Saibil FG, Fung LS, Levy GA. Monocyte procoagulant activity in Whipple disease. J. Clin Immunol 1984;
(5): 348-358.
Montes R, Reñé Espinet JM. Enfermedad de Whipple: consideraciones diagnósticas y terapêuticas. Rev Esp Enf Digest
; 81:58-59.
Cooper GS, Blades EW, Remler BF et al. Central nervous system Whipple’s disease: relapse during therapy with trimethoprimsulfamethoxazole and remission with cefixime. Gastroenterology 1994; 106: 782-786.
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2002 Internal Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
