Mortal adverse reaction to Rifampicin – A clinical case report

Authors

  • Raul Lobato de Faria Interno do Internato Complementar de Oncologia Médica, Unidade de Cuidados Intensivos do Hospital de Curry Cabral
  • Paulo Marcelino Assistente Hospitalar de Medicina Interna, Unidade de Cuidados Intensivos do Hospital de Curry Cabral
  • Susan Marum Assistente Hospitalar de Medicina Interna, Unidade de Cuidados Intensivos do Hospital de Curry Cabral
  • Joaquim Ribeiro Chefe de Serviço de Medicina Interna, Unidade de Cuidados Intensivos do Hospital de Curry Cabral

Keywords:

rifampicin, adverse reaction, haemolysis

Abstract

The prevalence of Mycobacterium tuberculosis infection
and the relevance of rifampicin in its treatment led
us to present the following clinical case report, which
is characterized by multi-organic failure in the
context of an adverse reaction to rifampicin.
Secondary effects to drugs deserve special
attention and, in the case of rifampicin we should
be specially alerted to intermittent and previous
therapy with possible patient’s sensitization to the drug.

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References

Reese RE, Betts RF. Antibiotic use – Reese-Douglas 3rd Ed.

Girling DJ et al – Adverse reactions to rifampicin. Bull. WHO 1979; 57: 45-49.

Martinez E, Collazos J, Mayo J. Hypersensitivity reactions to rifampin. Pathogenic mechanisms, clinical manifestations,

management strategies and review of the anaphylactic-like reactions – Medicine (Baltimore) 1999; 78(6): 361-369.

Grosset J et al. Adverse effects of rifampicin – Ver Inf Dis 1983; 5 (30): S440-446.

Goodman and Guilman’s, The Pharmacological Basis of Therapeutics,, 9th edition, 1996.

Warrington RJ et al. Insidious rifampin-associated renal failure with light chain proteinuria – Arch Intern Med 1977; 137: 927-

De Vriese AS, Robbrecht DL, Vanholder RC, Vgelaers DP, Lameire NH. Rifampicin-associated acute renal failure: pathophysiologic,

immunologic and clinical features. Am J Kidney Dis 1998 ; 31(1): 108-115.

Gillies HC et al. A textbook of Pharmacology – 2nd Ed. 1990.

Nessi R, Bonoldi GL, Redaelli B, di Fillipo G. Acute renal failure after rifampicin: a case report and survey literature. Nephron 1976;

(2): 148-159.

Fardet L, Lalande V, Meyohas MC, Frottier J, Meynard JL. Severe immunoallergic reaction in a patient treated for two months

continuously with rifampicin. Presse Med 1999; 27; 28(37): 2037-2038.

Arrizabalaga J, Casas A, Camino X, Irribarren JÁ, Rodriguez Arrondo F, Von Wichmann MA. The usefulness of the

desensibilization to rifampin in the treatment of mycobacterial disease in patients with AIDS. Med Clin (Barc) 1998 ; 111(3):

-104.

Denis J, Robert A, Johanet C, Homberg JC, Opolon P, Levy VG. Immunoallergic complication induced by rifampicin with

disseminated intravascular coagulation. Presse Med 1983; 12(23): 1479-1481

Additional Files

Published

2001-06-29

How to Cite

1.
Lobato de Faria R, Marcelino P, Marum S, Ribeiro J. Mortal adverse reaction to Rifampicin – A clinical case report. RPMI [Internet]. 2001 Jun. 29 [cited 2024 Nov. 23];8(2):76-9. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1947

Issue

Section

Case Reports

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