Anaemia of chronic diseases
Keywords:
Anaemia, chronic disease, macrophages, interleukins, pathogenesis, erythropoietinaAbstract
The authors review and discuss the current concepts concerning anaemia which coexists with multiple chronic diseases, denominated "Anaemia of Chronic Diseases". This is the most common form of anaemia in hospitalised medical patients. lt se/dom requires treatment as it normally resolves once the underlying disease has been successfully controlled.
The most important pathogenic mechanism is a block in the re-utilisation of haemoglobin iron. A mechanism, mediated by the release of interleukins and other infiammation mediators, in response to tissue damage.
ln terms of differential diagnosis, the problem is to distinguish between "Anaemia of Chronic Diseases" and "Sideropenic Anaemia" as the appropriate treatment differs.
The therapeutic role of erythropoietin is discussed.
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