The abstinence in alcoholism. The changes in carbohydrate-deficient transferrin (CDT)

Authors

  • Jorge Peneda Investigador Responsável do Núcleo de Alcoologia do Instituto Nacional de Saúde
  • Aidil Fonseca Técnico superior do Instituto Nacional de Saúde
  • Cristina Ribeiro Assistente de Clínica Geral do Centro Regional de Al­coologla de Lisboa
  • Teresa Sá Nogueira Assistente Graduada de Psiquiatria do Centro Regi­onal de Alcoologia de Lisboa
  • Mª Celeste Dias Enfermeira Chefe do Centro Regional de Alcoologia de Lisboa
  • Soledade Gomes Dietista do Centro Regional de Alcoologia de Lisboa
  • Domingos Neto Director do Centro Regional de Alcoologia de Lis­boa

Keywords:

alcoholism, abstinence, carbo­ hydrate deficiency transferrin, iron status

Abstract

Presentemente, a transferrina deficiente em carbo-hidratos -(CDT) é o marcador biológi­co acessível mais apropriado na discriminação do consumo persistente de álcool.

Um grupo de 55 doentes álcool-dependentes, internados para tratamento e recuperação no Centro Regional de Alcoologia de Lisboa, após 4 semanas de abstinência controlada, vem a sofrer quebras significativas dos níveis mé­dios de transferrina anormal No entanto, nesta condição, permanecem ainda frequências deste marcador mais elevadas que os níveis de re­ferência convencionais, nomeadamente nos ál­cool-dependentes com infecção virai (VHB, VHC). Estas frequências vêm a ser, contudo, bem inferiores às frequências anormais dos marcadores tradicionais (AST/ALT/GGT) de álcool-dependentes sob abstinência, nomeada­mente naqueles com infecção vira o que vem a revelar a sua melhor especificidade no al­coolismo/ abstinência. Também as frequências de índices anormais do status do ferro são mais elevadas nos álcool-dependentes sob abstinência, nomeadamente com infecção viral que na população referência, sendo útil a apreci­ação crítica de níveis de transferrina por esta se correlacionar com as suas isoformas indu­ zidas pelo álcool.

Os dados aconselham a necessidade da de­ terminação dos níveis de transferrina anor­mal no álcool-dependente sob abstinência con­trolada, que deverá ser o valor de referência individual na vigilância subsequente de ma­nutenção da ausência de consumos.

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Additional Files

Published

1998-12-31

How to Cite

1.
Peneda J, Fonseca A, Ribeiro C, Sá Nogueira T, Dias MC, Gomes S, Neto D. The abstinence in alcoholism. The changes in carbohydrate-deficient transferrin (CDT). RPMI [Internet]. 1998 Dec. 31 [cited 2024 Dec. 18];5(4):224-31. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2155

Issue

Vol. 5 No. 4 (1998): Outubro/ Dezembro

Section

Original Articles

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