ldiopathic esophageal ulcers in a VIH+ woman: thalidomide therapy

Authors

  • Margarida Bentes de Jesus Assistente Hospitalar de Medicina Interna, Serviço de Medicina do Hospital de S. José, Lisboa
  • Helena Nunes Interna do Complementar de Medicina Interna, Serviço de Medicina do Hospital de S. José, Lisboa
  • Isabel Ortigueira Interna do Complementar de Medicina Interna, Serviço de Medicina do Hospital de S. José, Lisboa

Keywords:

thalidomide, HIV, AIDS, idiopathic esophageal ulcers, idiopathic esophagitis

Abstract

We present the case of an HIV+ woman with idiopathic esophageal ulcers with an excellent response to thalidomide therapy, which also in­duced the remission of a concomitant febrile syn­drome. Thalidomide's mechanism of action in this situation is unknown, but it could be related to the effects of the drug on the immune system, or to a direct anti-retroviral effect.

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References

Connolly GM, Hawkins D, Harcourt-Webster JN, Parsons PA, Husain OAN, Gazzard BG. Oesophageal symptoms, their causes, treatment, and prognosis in patients with the ac­quired immunodeficiency syndrome. Gut 1989; 30: 1033-1039

Laine L, Bonacini M. Esophageal disease in human immunodeficiency virus infection. Arch Intern Med 1994; 154: 1577-

Kitchen VS, Helbert M, Francis ND, et al. Epstein-Barr virus associated oesophageal ulcers in AIDS. Gut 1990; 31: 1223-1225.

Rabeneck L, Popovic M, Gartner S, et al. Acute HIV infection presenting with painful swallowing anel esophageal ulcers. JAMA 1990; 263; 2318-2322.

Wilcox CM, Schwartz DA, Clark WS. Esophageal ulceration in human immunodeficiency virus infection. Causes, response to therapy, and long-term outcome. Ann Intern Med 1995; 122: 143-149.

Youle M, Clarbour J, Farthing C, et al. Treatment of resistant aphtous ulceration with thalielomide in patients positive for HIV antibody. Br Med J 1989; 298: 432.

Ghigliotti G, Repeno T, Farris A, Roy MT, De Marchi R. Thali­domide: Treatment of choice for aphtous ulcers in patients seropositive for human immunodeficiency virus. J Am Acad Dermatol 1993; 28: 271-272.

Ryan J, Colman J, Pedersen J, Benson E. Thalidomiele to treat esophageal ulcer in AIDS. New Engl J Med 1992; 327: 208- 209

Bodokh I, Lacour JP, Rainero C, Castanet J, Michiels JF, Orton­ne JP. Efficacité du thalidomide sur les ulcérationsoeso­ phagiennes au cours ele l'infection à VIH. Presse Méd 1993; 22: 1233.

Paterson DL, Georghiou PR, Allworth AM, Kemp RJ Thalido­miele as treatment of refractory aphtous ulceration related to human immunodeficiency infection. Clin Inf Ois 1995; 20: 250-254.

Couderc IJ, Mathez D, Leibowitch J, Autran B, Caubarrere I. Traitement prolongé par thalidomide chez un malade in­fecté parle VIH. Presse Méd 1995; 24: 40.

Naum SM, Molloy PJ, Kania RJ, McGarr J, Van Thiel DH. Use of thalielomide in treatment and maintenance of idiopathic esophageal ulcers in HIV+ individuais. Dig Dis Sci 1995; 40: 1147-1148.

Revuz J, Guillaume J-C, Janier M, et al. Crossover study of thalidomide vs placebo in severe recurrent aphtous sto­ matitis. Arch Dermatol 1990; 126: 923-927.

Gutiérrez-Rodríguez O, Starusta-Bacal P, Guttiérrez-Montes O, et al. Treatment of refractory rheumatoied arthritis - the thaliclomide experience. J Rheumatól 1989; 2: 158-163.

Vogelsang GB, Farmer ER, Hess AD, et al. Thalidomide for the treatment of chronic graft-versus-host disease. New Engl J Med 1992; 326: 1055-1058.

Ochonisky S, Revuz J, Utilisation thérapeutique du thalidomi­de. Cone Méd 1995; 117: 98-102.

Strazzi S, Lebbe C, Geoffray C, et al. Aphtous ulcers in HIV­ infected patients: treatment with thalidomide. Genitour Med

; 68: 424-425.

Georghiou PR, Allworth AM. Thalidomide in painful AIDS­ associated proctits. J Infect Dis 1992; 166: 939-940.

Verberkmoes A, Boer K, Wertheim P, Bronkhorst CM, Lange J. Thalidomide for genital ulcer in HIV-positive woman. Lan­cet 1996; 347: 974.

Makonkawkeyoon S, Limson-Pobre RN, Moreira AL, Schauf V, Kaplan G. Thalidomide inhibits the replication of immu­nodeficiency vírus type 1. Proc Natl Acad Sci USA 1993; 90: 5974-5978.

Sampaio EP, Kaplan G, Miranda A, et al. The influence of thalidomide on the clinical and immunologic manifestations of erythema nodosum leprosum. J lnfect Dis 1993; 168: 408- 414.

Schuler U, Ehninger G. Thalidomide: Rationale for renewed use in immunological disorders. Drug Safety 1995; 12: 364-369.

Sharpstone D, Rowbottom A, Nelson M, et al. The treatment of microsporidial diarrhoea with thalidomide. AIDS 1995; 9: 658-959.

Thalidomide available to AIDS patients under expanded ac­cess program. Http://www.healthworks.eo.uk/hw/news/ DoctorsGuide4.html.

Additional Files

Published

1997-03-31

How to Cite

1.
Bentes de Jesus M, Nunes H, Ortigueira I. ldiopathic esophageal ulcers in a VIH+ woman: thalidomide therapy. RPMI [Internet]. 1997 Mar. 31 [cited 2024 Nov. 17];4(1):40-2. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2188

Issue

Vol. 4 No. 1 (1997): Janeiro/ Março

Section

Case Reports

License

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2023 Medicina Interna

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