Lyme disease: the present status

Authors

  • Ana Cabral Assistente Hospitalar de Medicina Interna, Serviço de Medicina I do Hospital de Egas Moniz, Lisboa
  • Eduardo Melo Interno do Internato Complementar de Medicina Interna, Serviço de Medicina I do Hospital de Egas Moniz, Lisboa

Keywords:

Borrelia burgdorferi, Lyme disea­se, erythema migrans, Lyme arthritis

Abstract

Lyme disease is a complex multisystemic di­sorder with a rising incidence worldwide. It is a tick-borne infectious disease caused by a newly recognized spirochete, Borrelia burgdorferi. Lyme disease may mimic and should be differen­ ciated from other immune-mediated disorders as its symptoms may include neurologic, joint, eye or cardiac abnormalities, as well as the typical skin lesion.

The authors describe some new concepts on epidemiology, and clinical characteristics of the disease as well as its diagnosis and treatment.

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References

Burgdorfer W, Barbour AG, Hayer SF, Benach JL, Grunwaldt E, Davis JP. Lyme Disease - a tick borne spirochetosis? Sience 1982; 216:1317-1319

Johnson RC, Schmid GP, Hyde FW, Steigerwalt AG, Brenner DJ. Borrelia Burgdorferi sp. nov.:etiologic agent of lyme disease. N Engl J Med 1983; 308:733-740.

Steere AC, Broderick TF, Malawista SE. Erythema chronicum migrans anel Lyme arthritis: epidemiologic evidence for a tick vector. Am J Epidemiol 1978; 108:312-321.

Wallis RC, Brown SE, Kloter KO, Main AJ Jr. Erythema chroni­cum migrans and Lyme arthritis: field study of tick. Am J Epidemiol 1978;108: 322-327.

Afezlius A. Erythema Chronicum migrans. Acta Derm Venereol 1921; 2:120-125.

Lipschutz B. Weiterer Beitrag Zur Kenntris des "Erythema chro­nicum migrans". Acta Dermatol Syph 1923; 143:365-374.

Bannwarth A. Zur Klink Und Pathogenese der "Chronischen lymphocytarem Meningitis". Arch Psychiatr Nervenkr 1944; 117161-185.

Garin CH, Bujadoux. Paralysie par les tiques. J de Medicine de Lyon 1922; 71:765-767.

Steere AC, Malawista SE, Snydman DR, et al. Lyme arthritis: an epidemie of oligoarthritis in children and adults in three Connecticut communities. Arthritis Rheum 1977; 20:7-17.

Benach JL, Bosler EM, Hanrahan JP, et al. Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med 1983; 308:740-742.

Steere AC, Grodzicki RL, Kornblatt AN et al. The spirochetal etiology of Lyme disease. N Engl J Meel 1983; 308:733-740.

Stewart A, Glass J, Patel A, Watt G, Cripps A, Clancy R. Lyme arthritis in the Hunter Valley. Med J Aust 1982; 1:139.

Stanek G, Pletschette M, Flamm H, et al. European Lyme bor­reliosis. Ann NY Acad Sci 1988; 539:274-282.

Kawahata M, Baba S, lguchi K, Yamaguti N, Russel H. Lyme disease in Japan anel its possible incriminated tick vector, lxoeles persulcatus. J Infect Dis 1987; 156:854.

Dekonenko EJ, Steere AC Berareli VP, Kravchuk LN. Lyme borreliosis in the Soviet Union: a cooperative US-USSR re­port. J infect Dis 1988; 158:748-753.

Ai CX, Wen YX, Zhang YG, et al. Clinical manifestations and epidemiological characteristics of Lyme diease in Hailin county, Heilongjiang Province, China. Ann NY Acad Sci 1988; 539:302-313.

Baranton G, Postic D, Saint Girons I, et al. Delineation of borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov. and group VS 461 associated with Lyme Borreliosis. Int J Syst bacteriol 1992; 42:378-383.

Canica MM, Nato f, Du Merle L, Mazif J-CL, Baranton G, Pos­tic D. Monoclonal antiboelies for identification of borrelia afzelii sp. nov. associated with late cutaneous manifestati­ons of Lyme Borreliosis. Scanel J Infect Dis 1993; 25:441- 448.

Postic D, Belfaiza J, Isogal E, Saint Girons I, Grimont AD, Barantion G. A new genomic species in Borrelia burgelor­feri sensulato isolated from japanese ticks. Res Microbiol l 993;144:467-473.

Balmelli T, Piffaretti JC. Association between different clinicai manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Res Microbiol 1995; 146(4): 329-340.

Steere AC. Lyme Disease. N Engl J Med 1989; 321: 586-596.

Steere AC, Bartenhagen NJ, Craft JE, et al. The early clinical manifestation of Lyme. Ann Intern Med 1983; 99:76-82.

Asbrink E, Hovmark A. Early and late cutaneous manifestati­ons of Ixoeles-borne borreliosis (erythema migrans borre­liosis, Lyme Borreliosis). Ann NY Acael Sei 1988, 539:4-15.

Nadelman RB, Wormser GP. Erythema migrans and early Lyme disease. Am J Med 1995;98( 4A): l 5S-23S.

Asbrink E. Erythema Chronicum migrans Afzelius and acro­dermatitis chronica atrophicans. Acta Derm Venereol 1985; 118 (Supl.):29.

Leslie TA, Levell Nj, Cutler SJ et al. Acrodermatitis chronica atrophicans: a case report and review of the literature. Br J Dermatol 1994;131(5): 687-693.

Aberer E, Stanek G. Histological evidence for spirochetal ori­ gin of morphea and lichen sclerosus et astrophicans. Am J Dermatopathol 1987; 9:374-379.

Steere AC, Batsford WP, Weinberg M, et al. Lyme carditis: car­diac abnormalities of Lyme disease. Ann Intern Med 1980; 92:8-16.

Sigal LH. Early disseminated Lyme disease: cardiac manifes­tations. Am J Med 1995 Apr 24;98( 4A): 25S-28S.

Olson LJ, Okafor EC, Clements IP. Cardiac involvement in Lyme disease: manisfestations and management. Mayo Clin Proc 1986; 61745-749.

Bannwarth, A.: Cronische limphozytare Meningitis, entzun­ dliche Polyneuritis und '· Rheumatismus". Ein Beitrag zum Problem ''Allergie und Nervensystem". Arch F Psychiatr 1941; 113:284-376.

Pachener AR, Steere AC. The tracl of neurologic manifestati­ons of Lyme disease: meningitis, cranial neuritis, and racli­culitis. Neurology 1985; 35: 47-53.

Meier C, Grahmann F, Engelhardt A, Dumas M. Peripheral nerve disorders in Lyme-borrelioses. Acta Neuropathol 1989; 79:271-278.

Weder P, Wieclersheim B, Matter L, Steck A, Otto F. Chronic progressive involvement in Borrelia burgdorferi infection. J Neurol 1987; 234:40-43.

Steere AC, Gibofsky A, Patarroyo ME, Winchester RJ, Harclin JA, Malawista SE. Chronic Lyme artritis: clinical and immu­nogenetic differentiation from rheumatoid arthritis. Ann Intern Med 1979; 90:896-901.

Snyclman DR, Schenkei DP, Berardi VP, Lastavica CC, Pariser KM. Borrelia burgdorferi in joint fluid in chronic Lyme ar­thritis. J Neurol 1987; 234:40-43.

Steere AC, Gibofsky A, Patarroyo ME, Winchester RJ, Harclin JA, Malawista SE. Chronic Lyme artritis: clinical and immu­nogenetic differentiation from rheumatoidarthritis. Ann Intern Med 1979; 90:896-901.

Lesser RL. Ocular manifestations of Lyme disease. Am J Med 1995;98( 4A): 60S-62S.

Dressler S, Whalen JA, Reinhardt BN, Steere AC. Western blotting in the serodiagnosis of Lyme disease. J Infect Dis 1993;167: 392-400.

Cutler SJ, Wright DA. Predictive value of serology in diagno­sing Lyme borreliosis. J Clin Pathol. 1994;47( 4): 344-349.

Berland R, Fikrig E, Hardin J, Flaveli RA. Molecular characte­rization of the humoral response to the 41 kilodalton flage­llar antigen of Borrelia burgdorferi, the Lyme disease agent. Infect lmmun 1991; 59:3531-3535.

Misonne MC, Demaerschack I, Anthonissen F, Goclfroid E, De Kesel M, Bigaignon G, Hoet P. ELISA-negative Lyme disease patients can be detected by Polymerase Chain Reaction and Western blooting. ln V1 the International Conference on Lyme Borreliosis, Program and Abstracts Pl15T, Bologna, Italy, June 1994.

Magnarelli LA. Current status of laboratory diagnosis for Lyme disease. Am J Med 1995 Apr 24;98(4A): 10S-12S.

Demaersschalck I, Abclelouahid BM, De Kesel M, et ai. Simultaneous presence of clifferent Borrelia burgdorferi genos­pecies in biological fluíeis of Lyme disease patients. J Clin Microbiol 1995; 33(3): 602-608.

Van Dam AP, Kuiper H, Vos K, et al. Different genoespecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme Borreliosis. Clin Infect Dis 1993; 17:708-717.

Mursic VO et al ln vitro anel in vivo susceptibility in Borrelia burgdorferi. Eur Clin Microbiol 1987;6: 424-426.

Sigal LH. Persisting complaints attributed to chronic Lyme di­sease: possible mechanisms and implications for manage­ment. AmJ Med 1994;96: 365-374.

Weber K, Pfister HW. Clinical management of Lyme borrelio­ sis. Lancet 1994;343: 1017-1020.

Carvalho-Araújo F. Editorial: doença de Lyme - um alerta. Rev Port Doenç Infec 1986; 9 (2): 2-5.

David-de-Morais JA, Filipe A R, Núncio MS. Doença ele Lyme em Portugal: caso clínico. Rev Port Doenç Infec 1989; 12

(4) 261-274.

Girão F, Alexandre JC, Henriques P et al. Doença de Lyme. A propósito ele um caso clínico. Coimbra Méd 1990;11: 323- 327.

Filipe AR, David-de-Morais JA, Núncio MS. A doença de Lyme no sul de Portugal. Evidência laboratorial e epidemiológi­ca acerca da presença da Borrelia burgdorferi. Rev Port Doenç Infec 1990;13 (1): 45-50.

David-de-Morais JA. As borrelioses no sul do país. Perspecti­va ele saúde ambiental. Rev Port Doenç Infec 1991;14: 115- 119.

David-de-Morais JA. Ineficácia ela terapêutica com tetracicli­na na fase precoce da doença de Lyme. Escorço breve so­bre um caso clínico. Rev Port Doenç Infec 1992;15: 277- 284.

David-de-Morais JA, Leitão AL, Páscoa BGF, et al. Doença de Lyme. A nossa experiência clínica na região do Alentejo. Rev Port Doenç Infec 1992;15: 227-245.

Núncio MS, David-de-Morais JA, Filipe AR. Pesquisa de anti­ corpos anti-Borrelia burgdorferi numa população do dis­trito de Évora. Rev Port Doenç Infec 1992;15: 173-176.

Núncio MS, Peter O, Alves MJ et al. Isolamento e caracteriza­ção de Borrelias ele lxocles ricinus em Portugal. Rev Port Doenç Infec 1993;16:175-179.

David ele Morais JA. Doença de Lyme. Revisão actualizada. Rev Port Doenç Infec 1994;17: 129-137.

David de MoraisJA, AbranchesJ, Parra], et al. Artrite de Lyme, a propósito dos primeiros casos diagnosticados em Portu­gal. Rev Port Doenç Infec 1994;17: 183-195.

Ramos P, Fernandes C, Moreira J et al. Doença de Lyme, for­ma rara de apresentação. Med Int 1994;1(3): 161-165.

Colares Pereira M. Borrelia burgdorferi, o agente da Borrelio­se de Lyme. Monografia como complemento ela Tese de Doutoramento. IHMT s/d.

Ramos P, Fernandes C, Moreira J et al. Doença de Lyme, for­ma rara de apresentação. Med Int 1994;1(3): 161-165.

Colares Pereira M. Borrelia burgdorferi, o agente ela Borrelio­se de Lyme. Monografia como complemento ela Tese de Doutoramento. IHMT s/d.

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Published

1997-03-31

How to Cite

1.
Cabral A, Melo E. Lyme disease: the present status. RPMI [Internet]. 1997 Mar. 31 [cited 2024 Nov. 17];4(1):48-52. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2191

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Vol. 4 No. 1 (1997): Janeiro/ Março

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Review Articles

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