Non-steroidal anti-inflammatory drugs - General aspects and role in the treatment of cancer pain

Authors

  • Ferraz Gonçalves Assistente hospitalar de Medicina Interna, Unidade de Cuidados Paliativos do Instituto Português de Onco­logia, Porto

Keywords:

nonsteroidal anti-itiflammatory dru­gs, cancer pain, bone metastases

Abstract

The nonsteroidal anti-inflammatory drugs are very commonly used, for its well-known anti-in­flammatory, antipyretic, and analgesic activities. They can cause multipie side effects that, althou­gh rare in single doses, increase with multiple doses specially in the elderly. They interact with drugs that bind strongly to plasma proteins. NSAI­Ds are, such as paracetamol, first line agents for the treatment of mild to moderate cancer pain but can be used in other stages of the disease.

Downloads

Download data is not yet available.

References

Amadio P. Cummings DM, Amadio P Nonsteroidal anti-inflam­matory drugs. Postgrad Med 1993: 93 (4):73-97.

Schokr DW. Ku EC. Boettcher 1. Schweizer A Pharmacology of diclofenac sodium. Am J Med 1986:80 (Suppl 4B):34-38.

Rawlins MD. Non-opioid analgesics. ln Doyle D, Hanks GWC, Macdonald N. ed. Oxford textbook of palliative care. Oxford Medical Publications 1ª ed 1993: 182-187.

Brooks PM, Day RO. Nonsteroidal anti-inflammatory drugs - Di­fferences and similarities. N Engl JMed 1991:324: 1716-1725.

Eisenber. E. Tierkey CS, Carr DB, Mostdler F, Chalmers TC. Efficacy and safety of nonsteroidal anti-inflammatory drugs for can­cer pain: a meta-analysis. J Clin Oncol 1994; 12:2756-2765.

Hollandlér. Gastrointestinal complications of nonsteroidal anti-in­flammatory drugs: prophylactic and therapeutic strategies. Am

J. Med 1994: 96:274-281.

Bateman DX Kennedy JG. Non-steroidal anti-inflammatory drus and ederly patients. Br Med J 1995:310:817-818.

Heigh RI. Use of NSAIDs. Postgrad Med 1994: 96:63-68.

O'Brien WM. Adverse reactions of nonsteroidal anti-inflamma­tory drugs. Am J Med 1986: 80(Suppl 4BJ:70-80.

Marasco WA, Gikas PW. Azziz-Baumgartner R Hyzy R. Eldred­ge CJ, Strossj. lbuprofeno-associated renal dysfunction. Arch lntern Med 1987: 147:2107- 2116.

Clive DM, Stoff JS. Renal syndromes associated with nonsteroi­dal anti-inflammatory drugs. N Engl J Med 1984;310: 563-572.

Report of a meeting of physicians, University of Texas Medical School at Houston; and Texas Heart Institute at St Luke·s Epis­copal Hospital, Houston, Texas, CSA. >lephrotoxicity of non­ steroidal anti-inflammatory drugs. Lancet 1994: 344: 515-518

Helfgott SM, Sandherg-Cook J. Zakim D, Nestler J. Diclofenac­ associated hepatotoxicity. JAMA 1990: 264:2660-2662

Simon LS, Mills JA. Nonsteroidal anti-inflammatory drugs. N Eng J Med 1980:302: 1179-1183

Jacox A Carr DB, Payne R. New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med 1994: 330:651 -655.

Beaver WT. Impact of non-narcotic oral analgesics on pain ma­nagement. AmJ Med 1988,84 (suppl 5A): 3- 15.

Organisation mondiale de la Santé. Traitement de la douler can­céreuse et soins palliatif. Geneve 1990.

Pace V. Use of nosteridal anti-inflammatory drugs in cancer. Palliat Med 1995; 9:273-286.

Coomhes RC. Neville Am. Gazet JC. Ford HT, Nash AG, Baker Jw, Powles Tj. Agents affecting osteolysis in patients with bre­ast cancer. Cancer Chemother Pharmacol 1979: 3:41 - 44.

Gonçalves F. Metástases ósseas. Oncologia 1990: 1:179-189

Payne R. Parmacologic management of bone pain in cancer patient. Clin J Pain 1989; S(suppl 2):S43-S50

Foley K. The treatment of cancer pain. N Engl J Mcd 1985: 313: 84-95.

Portenoy RK. Cancer pain management 1993: 20 (suppl 2):19-35.

Additional Files

Published

1996-09-30

How to Cite

1.
Gonçalves F. Non-steroidal anti-inflammatory drugs - General aspects and role in the treatment of cancer pain. RPMI [Internet]. 1996 Sep. 30 [cited 2024 Nov. 23];3(3):172-7. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/2291

Issue

Section

Review Articles