Transplante medular no mieloma múltiplo
Keywords:
multiple myeloma, bone marrow trsnsplantation, intensive chemotherapy, allogenic bone marrow transplantation, autologous bone marrow transplantation, peripheral blood stem cellsAbstract
Multiple myeloma is a common disease in older persons, accounting for 10% of haematologic cancers. lts causes are unknown and its extent, clini cai course, complications and sensivity to drugs have a wide range of variation. Conventional chemotherapy is palliative: less than 5% live 10 ye ars and, among these, almost all have suffered multiple relapses. This review will focus there sults of high dose chemotherapy on the treatment of multiple myeloma, with bone marrow transplantation or peripheral blood stem cells support.
Downloads
References
Vesole DH, Jaganath S, Glenn L, Barlogie B. Autotransplatation in Multiple Myeloma. Hematol Oncol Clin North Am 1993; 7(3):613-630.
Alexanian R, Dimopoulos M. The treatment of Multiple Myeloma. N Engl J Med 1994; 330(7):484-489.
Armitage JO. Bone marrow Transplantation. N Engl J Med 1994: 330( 12): 827-838.
Barlogie B, Epstein J, Selvanayagam P, Alexanian R. Plasma Cell Myeloma - New Biological Insights anel Advances in Therapy. Blood 1989; 73(4):865-879.
Tura S, Cavo M, Jaganath S, Barlogie B. Allogenic Bane marrow transplantation in Multiple Myeloma / Autologous Bane Marrow Transplantation in Multiple Myeloma. Hematol Oncol Clin North Am 1992;6(2):425-462.
Oken MM, Appelbaum FR. Treatment of Multiple Myeloma. ln: Education Program American Society of Hematology eds. Hematology. Saint Louis, Missouri. 1993; 67-74.
Garthon G, Tura S, Ljungman P, Belanger C, Brandt L, Cavo M et al. Allogenic Bane Marrow Transplantation in Multiple Myeloma. N Engl J Med 1991; 325(18):1267-1273.
Ballester OF. Allogenic Bone Marrow Transplantation for Multiple Myeloma. Semin Oncol 1993; 20(5) Suppl 6:67-71.
Birei JM, Russel NH, Samson D. Minimal residual disease after bone marrow transplantation for multiple myeloma: evidence for cure in long-term survivals. Bone Marrow Transplant 1993; 12:651-654.
Gore ME, Vincler C;Meldrurn M, Bel! J, Milan S, Zuiable A et al. lntensive Treatment of Multiple Myeloma and criteria for Complete Remission. Lancet 1989;2:879-885.
Jaganath S, Barlogie B, Dicke K, Alexanian R, Zagars G, Cheson B et al. Autologous Bone Marrow Transplantation in Multiple Myeloma: Identification of Prognostic Factors. Blood 1990; 76(9):1860-1866.
Attal M, Huguet F, Schlaifer D, Payen C, Laroche M, Fournie B et al. Intensive Combined Therapy for Untreated Aggressive Myeloma. Blood 1992; 79(5):1130-1136
Harousseau JL, Milpiecl N, Laporte JP, Collombat P, Facon T, Ti gaucl JD et al. Double-Intensive Therapy in High-Risk Multi ple Myeloma. Bloocl 1992; 7901):2827-2833.
Dimoupoulos MA, Alexanian R, Przepiorka D, Hester J, Ander sen B, Giralt S et al. Thiotepa, Busulfan, anel Cydophospha micle: A New Preparative Regímen for Autologous Marrow or Bloocl Stern Cell Transplantation in High-Risk Multiple Mye loma. Bloocl 1993; 82(8):2324-8.
Reece DE, Barnet MJ, ConnorsJM, Klingemann HG, O'Reilly SE, Shephercl JD et al. Treatment of Multiple Myeloma with in tensive chemotherapy followecl by autologous BMT using marrow purgecl with 4-hyclroperoxycyclophosphamide. 13one Marrow Transplant 1993: 11:139-146.
Fermancl JP, Levy Y, Gerota J, Benbunan M, Cosset JM. Castaig ne S et al. Treatment of Aggressive Multiple Myeloma by High Dose Chemotherapy anel Total Body Irracliation Followecl hy Bloocl Stern Cells Autologous Graft. Bloocl 1989: 73( 1 ):20-23.
Jaganath S, Vesole DH, Glenn L, Crowley J, Barlogie B. Lo - Risk Intensive Therapy for Multiple Myeloma With Comhi necl Autologous Bone Marrow anel Bloocl Stern Cell Support. Blood 1992; 80(7) 1666-1672.
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 1995 Internal Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna
Open Access
