Surrounding Atrial Fibrillation in the Elderly Patients... Complex and Manifold
DOI:
https://doi.org/10.24950/rspmi.827Keywords:
Aged, Anticoagulants, Atrial Fibrillation, Decision Making, ComorbidityAbstract
Atrial fibrillation is the most common arrhythmia of the elderly.
The prevention of thromboembolic events (namely, stroke)
and oral anticoagulation is an imperative require. However,
atrial fibrillation in the elderly is a multifaceted clinical condition,
associated with multimorbidity, geriatric syndromes,
polypharmacy and overall frailty. Consequently, primary geriatric
care must include the assessment of functional status,
iterated review of medication and thoughtful consideration
of the potential benefits and adverse effects of treatment, in
order to achieve the proposed objectives. Oral anticoagulation
is often disapproved and less used. Shared decision-
-making is necessary. Properly sense of balance between
risks and benefits in the management of atrial fibrillation in
elderly patients with multiple comorbidities, often with clinical
frailty, is a complex challenge. This paper try to point out, at
a time when direct target-specific oral anticoagulants are an
alternative to warfarin, evaluate and talk about some of the
decision making process.
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Bonhorst D, Mendes M, Adragão P, De Sousa J, Primo J, Leiria E, et al. Prevalência de fibrilhação auricular na população portuguesa com 40 ou mais anos. Estudo FAMA. Rev Port Cardiol. 2010; 29: 331-50.
Vogel T, Geny B, Kaltenbach G, Lang PO. L’anticoagulation dans la fibrillation atriale du sujet âgé: point du vue du gériatre avec un focus sur
les anticoagulants oraux directs. Rev Med Interne. 2015; 36: 22-30.
Fernández CS, Formiga F, Camafort M, Rodrigo JMC, Díez-Manglano J, Reino AP, et al. Antithrombotic treatment in elderly patients with atrial
fibrillation: a practical approach. BMC Cardiovasc Disord. 2015;15:143.
Chen MA. Multimorbidity in older adults with atrial fibrillation. Clin Geriatr Med. 2016; 32: 315-29.
Carlson C, Merel SE, Yukawa M. Geriatric syndromes and geriatric assessment for the generalist. Med Clin North Am. 2015; 99: 263-79.
Carrageta MO, Silva PM. Avaliação da idade biológica. In: Abreu A, Araújo CG, Mendes M, Serra S, editores. Prevenção e Reabilitação Cardiovascular. Lisboa: Sociedade Portuguesa de Cardiologia; 2016.p. 61-72.
Hanon O, Baixas C, Friocourt P, Carrié D, Emeriau JP, Galinier M, et al. Consensus of the French Society of Gerontology and Geriatrics and the French Society of Cardiology for the management of coronary artery disease in older adults. Arch Cardiovasc Dis. 2009; 102: 829-45.
Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012; 33: 2719-47. Errata in: Eur Heart J. 2013; 34: 790. Eur Heart J. 2013; 34: 2850-1.
Kirchhof P, Breithardt G, Aliot E, Al Khatib S, Apostolakis S, Auricchio A, et al. Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. Europace. 2013; 15: 1540-56.
Ben Freedman S, Gersh BJ, Lip GY. Misperceptions of aspirin efficacy and safety may perpetuate anticoagulant underutilization in atrial fibrillation. Eur Heart J. 2015; 36: 653-6.
Andreotti F, Rocca B, Husted S, Ajjan RA, Ten Berg J, Cattaneo M, et al. Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis. Eur Heart J. 2015; 36: 3238-49.
Laliberté F, Moore Y, Dea K, LaMori JC, Mody SH, Jones JL, et al. Gastrointestinal comorbidities associated with atrial fibrillation. SpringerPlus. 2014; 3: 603.
Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral
anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014; 383: 955-62.
Desai J, Kolb JM, Weitz JI, Aisenberg J. Gastrointestinal bleeding with the new oral anticoagulants – defining the issues and the management strategies. Thromb Haemost. 2013; 110: 205-12.
Heidbuchel H, Verhamme P, Alings M, Antz M, Diener HC, Hacke W, et al. Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2015; 17: 1467-507.
Agewall S, Cattaneo M, Collet JP, Andreotti F, Lip GY, Verheugt FW, et al. Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy. Eur Heart J. 2013; 34: 1708-13.
Silva PM. Velhos e novos anticoagulantes orais. Perspetiva farmacológica. Rev Port Cardiol. 2012; 31(Supl. I): 6-16.
Staerk L, Lip GY, Olesen JB, Fosbøl EL, Pallisgaard JL, Bonde AN, et al. Stroke and recurrent haemorrhage associated with antithrombotic
treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study. BMJ. 2015; 351: h5876.
Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, et al. Two novel equations to estimate kidney function in persons aged 70
years or older. Ann Intern Med. 2012; 157: 471-81.
Harenberg J, Hentschel VA, Du S, Zolfaghari S, Krämer R, Weiss C, et al. Anticoagulation in patients with impaired renal function and with haemodialysis. Anticoagulant effects, efficacy, safety, therapeutic options. Hamostaseologie. 2015; 35: 77-83.
Sato RC, Zouain DM. Modelos de Markov aplicados a saúde. Einstein. 2010; 8: 376-9.
Kilickap M, Bosch J, Eikelboom JW, Hart RG. Antithrombotic treatments for stroke prevention in elderly patients with non-valvular atrial fibrillation: drugs and doses. Can J Cardiol. 2016; 32:1108-16.
Lazkani A, Delespierre T, Bauduceau B, Benattar-Zibi L, Bertin P, Berrut G, et al. Predicting falls in elderly patients with chronic pain and other chronic conditions. Aging Clin Exp Res. 2015; 27: 653-61.
Granziera S, Cohen AT, Nante G, Manzato E, Sergi G. Thromboembolic prevention in frail elderly patients with atrial fibrillation: a practical algorithm. J Am Med Dir Assoc. 2015; 16: 358-64.
Culebras A, Messé SR, Chaturvedi S, Kase CS, Gronseth G. Summary of evidence-based guideline update: prevention of stroke in nonvalvular atrial fibrillation: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014; 82:716-24.
Parks AL, Fang MC. Anticoagulation in older adults with multimorbidity. Clin Geriatr Med. 2016; 32: 331-46.
Kundu A, Sen P, Sardar P, Chatterjee S, Kapoor A, McManus DD. Intracranial hemorrhage with target specific oral anticoagulants in patients with atrial fibrillation: An updated meta-analysis of randomized controlled trials. Int J Cardiol. 2016; 203: 1000-2.
Gouveia M, Costa J, Alarcão J, Augusto M, Caldeira D, Pinheiro L, et al. Carga e custo da fibrilação auricular em Portugal. Rev Port Cardiol.
; 34: 1-11.
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