Evidence of Renin-Angiotensin System Modifiers in the Prevention of Episodic Migraine
DOI:
https://doi.org/10.24950/R/190/20/1/2021Keywords:
Angiotensin-Converting Enzyme Inhibitors, Migraine Disorders/prevention & controlAbstract
Introduction: Migraine is a common and disabling disease. Experimental models suggest an association between renin-angiotensin system and migraine development. This paper aims to review the evidence of angiotensin inhibitors in reducing migraine episodes.
Methods: We searched for guidelines, systematic reviews, meta-analysis and randomized controlled trials. Level of evidence and strength of recommendation (SOR) attribution were based on Strength of Recommendation Taxonomy (SORT).
Results: We identified 63 articles, from which we selected eight: four guidelines, two meta-analysis and two systematic review.
Discussion/Conclusion: Candesartan 16 mg/day may be used as a preventive treatment of episodic migraine (SOR B), in spite of not being recommended as the first line of treatment. Lisinopril also showed some potential. (SOR B).
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