Registadores de Eventos Implantados no Diagnóstico de Síncope

Autores

DOI:

https://doi.org/10.24950/rspmi/Revisao/63/18/2/2019

Palavras-chave:

Diagnóstico por Computador, Monitorização Ambulatorial, Síncope/diagnóstico

Resumo

No diagnóstico de pacientes com síncope é fundamental
que a etiologia seja determinada corretamente. Desta forma,
na avaliação destes doentes é essencial uma abordagem
multifacetada, combinando uma história clínica meticulosa
com um exame físico e exames auxiliares de diagnóstico
adequados. No entanto, mesmo com uma correta abordagem inicial, muitos pacientes são mal diagnosticados ou
permanecem sem diagnóstico, tornando-se assim candidatos a um seguimento prolongado.
O implantable loop recorder (ILR) é um aparelho de pequenas dimensões que permite uma monitorização prolongada
(até 3 anos) da atividade elétrica cardíaca, aumentando a
probabilidade de detetar uma correlação entre eventuais
alterações do ritmo cardíaco e os sintomas do paciente. Assim, os ILR têm assumido um interesse crescente nesta área
dado que permitem detetar a etiologia cardíaca (arrítmica)
de muitas síncopes que até então permaneciam de causa
desconhecida.
As guidelines atuais recomendam o uso dos ILRs na fase
precoce da avaliação de pacientes com síncopes recorrentes de causa desconhecida, após avaliação inicial, na ausência de critérios de alto risco e na avaliação de pacientes
de alto risco com síncope após avaliação inicial negativa.
Este artigo é uma revisão sistemática que resume o conhecimento atual sobre a utilidade e a precisão dos ILRs no
diagnóstico de síncope de causa desconhecida após uma
abordagem diagnóstica convencional, tal como a sua utilidade em diversas situações específicas (na epilepsia, na
população pediátrica, em idosos, na fibrilação auricular e no
AVC criptogénico).

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Referências

Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm JB, et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J. 2009;30:2631-71.

Sun BC, Emond JA, Camargo CA Jr. Characteristics and admission patterns of patients presenting with syncope to U.S. emergency departments, 1992-2000. Acad Emerg Med. 2004;11:1029-34.

Chen LY, Shen WK, Mahoney DW, Jacobsen SJ, Rodeheffer RJ. Prevalence of syncope in a population aged more than 45 years. Am J Med. 2006;119:1088.e1-7.

Lamb LE, Green HC, Combs JJ, Cheeseman SA, Hammond J. Incidence of loss of consciousness in 1,980 Air Force personnel. Aerospace Med. 1960;31:973-88.

Sun BC. Quality-of-life, health service use, and costs associated with syncope. Prog Cardiovasc Dis. 2013;55:370-5. doi: 10.1016/j. pcad.2012.10.009.

Lee AK, Krahn AD. Evaluation of syncope: focus on diagnosis and treatment of neurally mediated syncope. Expert Rev Cardiovasc Ther. 2016;14:725-36. doi: 10.1586/14779072.2016.1164034.

Linzer M, Pontinen M, Gold DT, Divine GW, Felder A, Brooks WB. Impairment of physical and psychosocial function in recurrent syncope.J Clin Epidemiol. 1991;44:1037-43.

Kapoor WN. Syncope. New Engl J Med. 2000;343:1856-62.

Brignole M, Menozzi C, Moya A, Garcia-Civera R. Implantable loop recorder: towards a gold standard for the diagnosis of syncope? Heart. 2001;85:610-2.

Brignole M, Vardas P, Hoffman E, Huikuri H, Moya A, Ricci R, et al. Indications for the use of diagnostic implantable and external ECG loop recorders. Europace. 2009;11:671-87. doi: 10.1093/europace/eup097.

Krahn AD, Klein GJ, Yee R, Takle-Newhouse T, Norris C. Use of an extended monitoring strategy in patients with problematic syncope. Reveal Investigators. Circulation. 1999;99:406-10.

Giada F, Bertaglia E, Reimers B, Noventa D, Raviele A. Current and emerging indications for implantable cardiac monitors. Pacing Clin Electrophysiol. 2012;35:1169-78. doi: 10.1111/j.1540-8159.2012.03411.x.

Zimetbaum P, Goldman A. Ambulatory arrhythmia monitoring: choosing the right device. Circulation. 2010;122:1629-36.

Rogers G, O’Flynn N. NICE guideline: transient loss of consciousness (blackouts) in adults and young people. Br J Gen Pract. 2011;61:40-2. doi: 10.3399/bjgp11X548965.

Abi Khalil C, Haddad F, Al Suwaidi J. Investigating palpitations: the role of Holter monitoring and loop recorders. BMJ. 2017;358:j3123. doi: 10.1136/bmj.j3123.

Locati ET, Moya A, Oliveira M, Tanner H, Willems R, Lunati M, et al. External prolonged electrocardiogram monitoring in unexplained syncope and palpitations: results of the SYNARR-Flash study. Europace. 2016;18:1265-72. doi: 10.1093/europace/euv311.

Solbiati M, Costantino G, Casazza G, Dipaola F, Galli A, Furlan R, et al. Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope. Cochrane Database Syst Rev. 2016 ;4:CD011637. doi: 10.1002/14651858.CD011637.pub2.

Schnipper JL, Kapoor WN. Diagnostic evaluation and management of patients with syncope.Med Clin North Am. 2001;85:423-56, xi.

Anderson JB, Czosek RJ, Knilans TK, Marino BS. The effect of paediatric syncope on health-related quality of life. Cardiol Young. 2012;22:583-8.

Ammirati F, Colivicchi F, Santini M. Diagnosing syncope in clinical practice. Implementation of a simplified diagnostic algorithm in a multicentre prospective trial - the OESIL 2 study (Osservatorio Epidemiologico della Sincope nel Lazio). Eur HeartJ. 2000;21:935-40.

Blanc JJ, L’Her C, Touiza A, Garo B, L’Her E, Mansourati J. Prospective evaluation and outcome of patients admitted for syncope over a 1 year period. Eur Heart J. 2002;23:815-20.

Crane SD. Risk stratification of patients with syncope in an accident and emergency department. Emerg Med J. 2002;19:23-7.

Day SC, Cook EF, Funkenstein H, Goldman L. Evaluation and outcome of emergency room patients with transient loss of consciousness. Am J Med. 1982;73:15-23.

Martin GJ, Adams SL, Martin HG, Mathews J, Zull D, Scanlon PJ. Prospective evaluation of syncope. Ann Emerg Med. 1984;13:499-504.

Colivicchi F, Ammirati F, Melina D, Guido V, Imperoli G, Santini M. Development and prospective validation of a risk stratification system for patients with syncope in the emergency department: the OESIL risk score. Eur Heart J. 2003;24:811-9.

Quinn JV, Stiell IG, McDermott DA, Sellers KL, Kohn MA, Wells GA. Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes. Ann Emerg Med. 2004;43:224-32.

Kang GH, Oh JH, Kim JS, On YK, Song HG, Jo IJ, et al. Diagnostic patterns in the evaluation of patients presenting with syncope at the emergency or outpatient department. Yonsei Med J. 2012;53:517-23. doi: 10.3349/ymj.2012.53.3.517.

Pires LA, Ganji JR, Jarandila R, Steele R. Diagnostic patterns and temporal trends in the evaluation of adult patients hospitalized with syncope. Arch Intern Med. 2001;161(15):1889-95.

Rangel I, Freitas J, Correia AS, Sousa A, Lebreiro A, de Sousa C, et al. The usefulness of the head-up tilt test in patients with suspected epilepsy. Seizure. 2014;23:367-70. doi: 10.1016/j.seizure.2014.02.004.

Kanjwal K, Karabin B, Kanjwal Y, Grubb BP. Differentiation of convulsive syncope from epilepsy with an implantable loop recorder. Int J Med Sci. 2009;6:296-300.

Petkar S, Hamid T, Iddon P, Clifford A, Rice N, Claire R, et al. Prolonged implantable electrocardiographic monitoring indicates a high rate of misdiagnosis of epilepsy--REVISE study. Europace. 2012;14:1653-60. doi: 10.1093/europace/eus185.

Zaidi A, Clough P, Cooper P, Scheepers B, Fitzpatrick AP. Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause. J Am Coll Cardiol. 2000;36:181-4.

Driscoll DJ, Jacobsen SJ, Porter CJ, Wollan PC. Syncope in children and adolescents. J Am Coll Cardiol. 1997;29:1039-45.

McLeod K. Dizziness and syncope in adolescence. Heart.2001;86:350-4.

Al Dhahri KN, Potts JE, Chiu CC, Hamilton RM, Sanatani S. Are implantable loop recorders useful in detecting arrhythmias in children with unexplained syncope? Pacing Clin Electrophysiol. 2009;32:1422-7. doi: 10.1111/j.1540-8159.2009.02486.x.

Rossano J, Bloemers B, Sreeram N, Balaji S, Shah MJ. Efficacy of implantable loop recorders in establishing symptom-rhythm correlation in young patients with syncope and palpitations. Pediatrics. 2003;112:e228-33.

Kothari DS, Riddell F, Smith W, Voss J, Skinner JR. Digital implantable loop recorders in the investigation of syncope in children: benefits and limitations. Heart Rhythm. 2006;3:1306-12.

Frangini PA, Cecchin F, Jordao L, Martuscello M, Alexander ME, Triedman JK, et al. How revealing are insertable loop recorders in pediatrics? Pacing Clin Electrophysiol. 2008;31:338-43.

Hartholt KA, van der Velde N, Looman CW, van Lieshout EM, Panneman MJ, van Beeck EF, et al. Trends in fall-related hospital admissions in older persons in the Netherlands. Arch Intern Med. 2010;170:905-11.

Albert M, McCaig LF, Ashman JJ. Emergency department visits by persons aged 65 and over: United States, 2009-2010. NCHS Data Brief. 2013;130:1-8.

Davies AJ, Kenny RA. Falls presenting to the accident and emergency department: types of presentation and risk factor profile. Age Ageing. 1996;25:362-6.

Brignole M, Menozzi C, Maggi R, Solano A, Donateo P, Bottoni N, et al. The usage and diagnostic yield of the implantable loop-recorder in detection of the mechanism of syncope and in guiding effective antiarrhythmic therapy in older people. Europace. 2005;7:273-9.

Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, et al. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Europace. 2013;15:1070-118. doi: 10.1093/europace/eut206.

Bhangu J, McMahon CG, Hall P, Bennett K, Rice C, Crean P, et al. Long- -term cardiac monitoring in older adults with unexplained falls and syncope. Heart. 2016;102:681-6. doi: 10.1136/heartjnl-2015-308706.

Furukawa T, Maggi R, Bertolone C, Fontana D, Brignole M. Additional diagnostic value of very prolonged observation by implantable loop recorder in patients with unexplained syncope. J Cardiovasc Electrophysiol. 2012;23:67-71. doi: 10.1111/j.1540-8167.2011.02133.x.

Giada F, Gulizia M, Francese M, Croci F, Santangelo L, Santomauro M, et al. Recurrent unexplained palpitations (RUP) study comparison of implantable loop recorder versus conventional diagnostic strategy. J Am Coll Cardiol. 2007;49:1951-6.

Khalil Kanjwal M, Vincent M. Figueiredo M, Beverly Karabin P, Blair P. Grubb M. The Implantable Loop Recorder: Current Uses, Future Directions. The Journal of Innovations in Cardiac Rhythm Management. 2011.

Krahn AD, Klein GJ, Yee R, Hoch JS, Skanes AC. Cost implications of testing strategy in patients with syncope: randomized assessment of syncope trial. J Am Coll Cardiol. 2003;42:495-501.

Krahn AD, Klein GJ, Yee R, Skanes AC. Randomized assessment of syncope trial: conventional diagnostic testing versus a prolonged monitoring strategy. Circulation. 2001;104:46-51.

Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112:1142-7.

Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e257-354.

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017;135:e146-e603.

Dagres N, Kottkamp H, Piorkowski C, Weis S, Arya A, Sommer P, et al.Influence of the duration of Holter monitoring on the detection of arrhythmia recurrences after catheter ablation of atrial fibrillation: implications for patient follow-up. Int J Cardiol. 2010;139:305-6. doi: 10.1016/j. ijcard.2008.10.004.

Hindricks G, Piorkowski C, Tanner H, Kobza R, Gerds-Li JH, Carbucicchio C, et al. Perception of atrial fibrillation before and after radiofrequency catheter ablation: relevance of asymptomatic arrhythmia recurrence. Circulation. 2005;112:307-13.

Roche F, Gaspoz JM, Da Costa A, Isaaz K, Duverney D, Pichot V, et al. Frequent and prolonged asymptomatic episodes of paroxysmal atrial fibrillation revealed by automatic long-term event recorders in patients with a negative 24-hour Holter. Pacing Clin Electrophysiol. 2002;25:1587-93.

Ziegler PD, Koehler JL, Mehra R. Comparison of continuous versus intermittent monitoring of atrial arrhythmias. Heart Rhythm. 2006;3:1445-52.

Flaker GC, Belew K, Beckman K, Vidaillet H, Kron J, Safford R, et al. Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am HeartJ. 2005;149(4):657-63.

Healey JS, Connolly SJ, Gold MR, Israel CW, Van Gelder IC, Capucci A, et al. Subclinical atrial fibrillation and the risk of stroke. New Engl J Med. 2012;366:120-9.

Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129:837-47. doi: 10.1161/CIRCULATIONAHA.113.005119.

Hindricks G, Pokushalov E, Urban L, Taborsky M, Kuck KH, Lebedev D, et al. Performance of a new leadless implantable cardiac monitor in detecting and quantifying atrial fibrillation: Results of the XPECT trial. Circ Arrhythm Electrophysiol. 2010;3:141-7.

Ajijola OA, Boyle NG, Shivkumar K. Detecting and monitoring arrhythmia recurrence following catheter ablation of atrial fibrillation. Front Physiol. 2015;6:90. doi: 10.3389/fphys.2015.00090.

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, et al. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace. 2012;14:528-606. doi: 10.1093/europace/eus027.

Hanke T, Charitos EI, Stierle U, Karluss A, Kraatz E, Graf B, et al. Twenty- -four-hour holter monitor follow-up does not provide accurate heart rhythm status after surgical atrial fibrillation ablation therapy: up to 12 months experience with a novel permanently implantable heart rhythm monitor device. Circulation. 2009;120(11 Suppl):S177-84.

Kircher S, Hindricks G, Sommer P. Long-term success and follow-up after atrial fibrillation ablation. Curr Cardiol Rev. 2012;8:354-61.

Mittal S, Pokushalov E, Romanov A, Ferrara M, Arshad A, Musat D, et al. Long-term ECG monitoring using an implantable loop recorder for the detection of atrial fibrillation after cavotricuspid isthmus ablation in patients with atrial flutter. Heart Rhythm. 2013;10:1598-604.

Gersak B, Pernat A, Robic B, Sinkovec M. Low rate of atrial fibrillation recurrence verified by implantable loop recorder monitoring following a convergent epicardial and endocardial ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2012;23:1059-66. doi: 10.1111/j. 1540-8167.2012.02355.x.

Pokushalov E, Romanov A, Corbucci G, Artyomenko S, Turov A, Shirokova N, et al. Ablation of paroxysmal and persistent atrial fibrillation: 1-year follow-up through continuous subcutaneous monitoring. J Cardiovasc Electrophysiol. 2011;22:369-75. doi: 10.1111/j.1540-8167.2010.01923.x.

Zuern CS, Kilias A, Berlitz P, Seizer P, Gramlich M, Muller K, et al. Anticoagulation after catheter ablation of atrial fibrillation guided by implantable cardiac monitors. Pacing Clin Electrophysiol. 2015;38:688-93. doi: 10.1111/pace.12625.

Pohl M, Mayer J, Gaspar T, Piorkowski C, Sitzy J, Huo Y, et al. Discontinuation of Anticoagulation with Continuous Remote Insertable Cardiac Monitoring in Atrial Fibrillation – The DACRIMA Study. Clin Res Cardiol.20016: 105, Suppl 2.doi 10.1007/s00392-016-1036-3

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095-128.

Adams HP, Jr., Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.

Guercini F, Acciarresi M, Agnelli G, Paciaroni M. Cryptogenic stroke: time to determine aetiology. J Thromb Haemost. 2008;6:549-54. doi: 10.1111/j.1538-7836.2008.02903.x.

Harloff A, Dudler P, Frydrychowicz A, Strecker C, Stroh AL, Geibel A, et al. Reliability of aortic MRI at 3 Tesla in patients with acute cryptogenic stroke. J Neurol Neurosurg Psychiatry. 2008;79:540-6.

Timsit S, Breuilly C. Cryptogenic cerebral infarction: from classification to concept. Presse Med. 2009;38:1832-42.

Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation. 2011;123:e18-e209.

Hohnloser SH, Pajitnev D, Pogue J, Healey JS, Pfeffer MA, Yusuf S, et al. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy. J Am Coll Cardiol. 2007;50:2156-61.

Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur HeartJ. 2012;33:2719-47.

Boriani G, Laroche C, Diemberger I, Fantecchi E, Popescu MI, Rasmussen LH, et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry. Am J Med. 2015;128:509-18.e2.

Barthelemy JC, Feasson-Gerard S, Garnier P, Gaspoz JM, Da Costa A, Michel D, et al. Automatic cardiac event recorders reveal paroxysmal atrial fibrillation after unexplained strokes or transient ischemic attacks. Ann Noninvasive Electrocardiol. 2003;8:194-9.

Hornig CR, Haberbosch W, Lammers C, Waldecker B, Dorndorf W. Specific cardiological evaluation after focal cerebral ischemia. Acta Neurol Scand. 1996;93:297-302.

Jabaudon D, Sztajzel J, Sievert K, Landis T, Sztajzel R. Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute stroke and transient ischemic attack. Stroke. 2004;35:1647-51.

Liao J, Khalid Z, Scallan C, Morillo C, O´Donnell M. Noninvasive cardiac monitoring for detecting paroxysmal atrial fibrillation or flutter after acute ischemic stroke: a systematic review. Stroke. 2007;38:2935-40.

Rem JA, Hachinski VC, Boughner DR, Barnett HJ. Value of cardiac monitoring and echocardiography in TIA and stroke patients. Stroke. 1985;16:950-6.

Schaer BA, Zellweger MJ, Cron TA, Kaiser CA, Osswald S. Value of routine holter monitoring for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemic events. Stroke. 2004;35:e68-70.

Schuchert A, Behrens G, Meinertz T. Impact of long-term ECG recording on the detection of paroxysmal atrial fibrillation in patients after an acute ischemic stroke. Pacing Clin Electrophysiol. 1999;22:1082-4.

Shafqat S, Kelly PJ, Furie KL. Holter monitoring in the diagnosis of stroke mechanism. Intern Med J. 2004;34:305-9.

Tagawa M, Takeuchi S, Chinushi M, Saeki M, Taniguchi Y, Nakamura Y, et al. Evaluating patients with acute ischemic stroke with special reference to newly developed atrial fibrillation in cerebral embolism. Pacing Clin Electrophysiol. 2007;30:1121-8.

Sinha AM, Diener HC, Morillo CA, Sanna T, Bernstein RA, Di Lazzaro V, et al. Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): design and rationale. Am Heart J. 2010;160:36-41.e1.

Providencia R, Candeias R, Morais C, Reis H, Elvas L, Sanfins V, et al. Financial impact of adopting implantable loop recorder diagnostic for unexplained syncope compared with conventional diagnostic pathway in Portugal. BMC Cardiovasc Disord. 2014;14:63. doi: 10.1186/1471-2261- 14-63.

Farwell DJ, Freemantle N, Sulke N. The clinical impact of implantable loop recorders in patients with syncope. Eur Heart J. 2006;27:351-6.

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18-06-2019

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dos Santos Oliveira T, Pedro Pinto Freitas J. Registadores de Eventos Implantados no Diagnóstico de Síncope. RPMI [Internet]. 18 de Junho de 2019 [citado 25 de Abril de 2024];26(2):126-34. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/385

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