Síndrome antifosfolipídica
DOI:
https://doi.org/10.24950/rspmi/revisao/4/2018Palavras-chave:
Acidente Vascular Cerebral, Anticorpos Anticardiolipina, Anticorpos Antifosfolipídeos, Síndrome AntifosfolipídicaResumo
A síndrome antifosfolipídica (SAF) carateriza-se pelo desenvolvimento de tromboses venosas e/ou arteriais, muitas vezes múltiplas, e pela morbidade gestacional (por perdas fetais recorrentes), na presença de anticorpos antifosfolipídicos. As estimativas indicam que a incidência da SAF é de cerca de 5 novos casos por 100 000 pessoas por ano e a prevalência é de cerca de 40-50 casos por 100 000 pessoas. Os aPL são positivos em aproximadamente 13% dos pacientes com acidente vascular cerebral, 11% com enfarte do miocárdio, 9,5% dos pacientes com trombose venosa profunda e 6% dos pacientes com morbidade gestacional. Atualmente, há consenso no tratamento de pacientes com SAF com trombose com anticoagulação oral de longa duração e para evitar manifestações obstétricas com o uso de aspirina e heparina. Esta revisão resume os principais conhecimentos sobre os aspectos clínicos e terapêuticos desta síndrome.
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