Síndrome de Churg-Strauss

Autores

  • B. F. Rodrigues Serviço de Nefrologia e Serviço de Medicina I do Hospital Fernando Fonseca
  • J. M. Araújo Serviço de Nefrologia e Serviço de Medicina I do Hospital Fernando Fonseca

Palavras-chave:

síndrome de Churg-Strauss, ANCA, vasculite

Resumo

A síndrome de Churg-Strauss é uma vasculite ANCA-associada de
pequenos e médios vasos. As manifestações clínicas mais comuns
são eosinofilia marcada, asma, sinusite crónica, infiltrados pulmonares, cardiomiopatia, queixas gastrointestinais e mononeurite
multiplex. Os anticorpos Anti-MPO (anti-mieloperoxidade), pANCA
(com padrão de imunoflurescência perinuclear) encontram-se
presentes em 38-59% dos casos. O envolvimento cardíaco é
uma importante causa de morbilidade e a principal causa de
mortalidade no síndrome de Churg-Strauss. Histologicamente
caracteriza-se por uma vasculite necrotizante eosinofílica.
O tratamento é baseado na corticoterapia e em fármacos imunosupressores (ciclofosfamida e azatioprina) sendo determinado
de acordo com critérios de prognóstico.
A remissão completa ocorre em cerca de 90% dos casos,
sendo as recaídas frequentes (25% dos casos).

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Ficheiros Adicionais

Publicado

30-09-2011

Como Citar

1.
Rodrigues BF, Araújo JM. Síndrome de Churg-Strauss. RPMI [Internet]. 30 de Setembro de 2011 [citado 30 de Maio de 2024];18(3):166-72. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1330

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