Linfoma pulmonar primário – a propósito de um caso clínico

Autores

  • Carla Gil Serviço de Medicina Interna do Hospital de Tomar, Centro Hospitalar do Médio Tejo
  • Carolina Correia Serviço de Medicina Interna do Hospital de Tomar, Centro Hospitalar do Médio Tejo
  • Edgar Pereira Serviço de Medicina Interna do Hospital de Tomar, Centro Hospitalar do Médio Tejo

Palavras-chave:

Linfoma pulmonar, BALT, MALT

Resumo

Descreve-se o caso de uma doente de 64 anos de idade que se
apresentou no Serviço de Urgência com queixas de tosse irritativa,
astenia intensa e perda ponderal não quantificada, com cerca de
dois meses de evolução. Dos antecedentes pessoais destaca-se
artrite reumatóide, em remissão há vários anos. A radiografia
torácica evidenciava uma massa ovóide no hilo esquerdo. Foi
só após a segunda broncofi broscopia com biopsia e exame
anatomopatológico que se chegou ao diagnóstico de linfoma
pulmonar primário.
Os linfomas pulmonares primários são raros. A forma mais
habitual de apresentação é o linfoma B não-Hodgkin da zona
marginal, extranodal, originado no tecido linfóide associado à
mucosa brônquica (BALT - Bronchus Associated Lymphoid Tissue),
também denominado linfoma pulmonar primário do tipo MALT
(Mucosa Associated Lymphoid Tissue).

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Referências

Cadranel J, Wislez M, Antoine M. Primary Pulmonary Lymphoma. Eur Respir J 2002; 20: 750–762.

Viji Sankaranarayanan, Tomasz M Zeidalski, Rajinder K Chitkara. A 55-Year-Old Smoker With a Persistent Right Lower Lobe Infiltrate. Chest 2005; 127: 2266-2270.

Octavian C, Ioachimescu, Sieber S, Walker M, Rella V, Kotch A. A 35-Year-Old Woman with Asthma and Polycystic Lung Disease. Chest 2002;

: 256-260.

Kim JH, Lee S, Park J et al. Primary Pulmonary Non-Hodgkin’s Lymphoma. Jpn J Clin Oncol 2004; 34(9) 510-514.

Cavalli F, Isaacson PG, Gascoyne RD, Zucca E. MALT Lymphomas. Hematology, American Society of Hematology 2001: 241-258.

Hiller AS, Tschernig T, Kleeman WJ, Pabst R. Bronchus-Associated Lymphoid tissue (BALT) and Larynx-Associated lymphoid tissue (LALT) are found at Different Frequencies in Children, Adolescents and Adults. Scand J Immunol 1998; 47: 159-162.

Váróczy L, Gergely L, Illés Á. Diagnostics and Treatment of Pulmonary BALT Lymphoma: a Report on Four Cases. Ann Hematol 2003; 82: 363-366.

Niewold T, Swaroop V. 78-Year-Old Woman with Fever, Weight Loss, and Rash. Mayo Clin Proc 2003; 78: 635-638.

Sutcliffe N, Smith C, Speight P e Isenberg D. Mucosa-associated lymphoid tissue lymphomas in two patients with rheumatoid arthritis on second-line agents, and secondary Sjögren’s syndrome. Rheumatology 2000; 39: 185-188.

Celso T, Mirle R, Ryland P et al. Methotrexate-Induced Pulmonary Lymphoma. Chest 2003; 123(6): 2150-2153.

Mariette X, Cazais-Hatem D, Warszawki J et al. Lymphomas in Rheumatoid Arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood 2002; 99(11): 3909-3915.

Inadoma Y, Ikezawa T, Oyasu R, Noguchi M. Malignant Lymphoma of Bronchus-associated Lymphoid Tissue (BALT) coexistent with Pulmonary Tuberculosis. Pathol Int 2001; 51(10): 807-811.

Grethlain S, Perez J. Mucosa-Associated Lymphoid Tissue. eMedicine.com 2005.

Ye H, Liu H, Attygalle A et al. Variable Frequencies of t(11;18)(q21;q21) in MALT Lymphomas of Different Sites: Significant Association with CagA Strains of H. pylori in Gastric MALT Lymphoma. Blood 2003; 102(3): 1012-1018.

Okabe M, Inagaki H, Ohshima K et al. API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue. Am J Pathol 2003; 162: 1113-1122.

Harris N, Jaffe E, Stein H et al. A Revised European-American Classification of Lymphoid Neoplasms: A Proposal from the International Lymphoma Study Group. Blood 1994; 84(5): 1361-1392.

Takamori M, Noma S, Kobashi Y, Inoue T, Gohma I, Mino M, Taguchi Y. CT Findings of Baltoma. Radiation Medicine 1999; 17 (5): 349-354.

Marchiori E, Valiante P, Telles A, Gutierrez M, Bodanese L, Souza A. Linfomas pulmonares: Correlação da Tomografia Computadorizada de Alta Resolução com a Anatamopatologia. Radiol Bras 2002; 35(1): 1-6.

Karadag F, Polath M, Kaçar F, Çildag O. A Case of Baltoma Diagnosed by Transthoracic True-Cut Needle Biopsy. Turk Respir J 2004; 5 (3): 178-182.

Zompi S, Couderc LJ, Cadranel J et al. Clonality Analysis of Alveolar B Lymphocytes Contributes to the Diagnostic Strategy in Clinical Suspicion of Pulmonary Lymphoma. Blood 2004; 103(8): 3208-3215.

Beal KP, Yeung HW, Yahalom J. FDG-PET scanning for Detection and Staging of Extranodal Marginal Zone Lymphomas of the MALT Type: a Report of 42 Cases. Ann Oncol 2005; 16(3): 473-480.

Solal-Céligny P, Roy P, Colombat P et al. Follicular Lymphoma International Prognostic Index. Blood 2004; 104(5): 1258-1265.

Tsang R, Gospodarowicz M, Pintilie M et al. Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Radiation Therapy has Excellent Clinical Outcome. J Clin Oncol 2003; 21(22): 4157-4164.

Zinzani P, Magagnoli M, Galieni P et al. Nongastrointestinal Low-Grade Mucosa Associated Lymphoid tissue Lymphoma: Analysis of 75 Patients. J Clin Oncol 1999; 17(4): 1254-1258.

Mounter P e Lennard. Classic diseases revisited: Management of non-Hodgkin’s lymphomas. Postgrad Med J 1999; 75: 2-6.

Hainsworth JD. Monoclonal Antibody Therapy in Lymphoid Malignancies. The Oncologist 2000; 5: 376-384.

Lee F, Wills M. Complete Pathologic Remission of BALT Lymphoma with Antibiotics Treatment: a Case Report. Reunião da American Society of Clinical Oncology 2001; 2655

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Publicado

29-09-2006

Como Citar

1.
Gil C, Correia C, Pereira E. Linfoma pulmonar primário – a propósito de um caso clínico. RPMI [Internet]. 29 de Setembro de 2006 [citado 21 de Novembro de 2024];13(3):189-96. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1646

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