Anticorpos anti-citoplasma de neutrófilos e monócitos - Apreciação da sua aplicação na práctica clínica
Palavras-chave:
vasculites, Wegener, ANCA, PR3, MPOResumo
Passada mais de uma década sobre a descoberta dos ANCA - Antineutrophil Cytoplasmic Antibodies - não se estabeleceram, ainda, critérios para uma correlação clínica no estudo dos síndromes vasculíticos.
Este artigo pretende rever a importância dos ANCA em alguns aspectos da fisiopatologia, diagnóstico e prognóstico das vasculites, no sentido de facilitar o diagnóstico diferencial.
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Referências
Davies DJ, Moran JE. Niall JF. Segmental nccrotising glomerulonephritis with antineutrophil antibody· possible arbovirus aetiology? BMJ 1982; 285. 606.
Jennctte JC, Falk RJ. Antineutrophil cytoplasmic autoantibodies and associated diseases: a review. Am J Kidney Dis 1990; 15: 517- 529.
Wieslander J. How are antineutrophil cytoplasmic autoantibodies detected? Am J Kidney Dis 1991; 18: 154-158.
Savige JA, Davies DJ, Gatenby PA. Antineutrophil cytoplasmic antibodies (ANCA): Their detection and significance: report from workshops. Pathology 1994; 26: 186-193.
Kallenberg et al. Antineutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential. Kidney lnt. 1994; 46: 1-15.
John L, Niles MD. Antineutrophil cytoplasmic antibodies in lhe classification of vasculitis. Annu Rev Med 1996; 47: 303-313.
Van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van Es LA et al. Autoantibodies against neutrophils and monocytes: too! for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancei 1985; 1: 425-429.
Nolle B, Specks U, Ludmann J, Rohrbach MS, DeRemee RA, Gross WL. Anticytoplasmic auto antibodies: their immunodiagnostic value in Wegner Granulomatosis. Ann lntern Med 1989; 111: 28-40.
Ulmer M, Rautmann A, Gross WL. lmmunodiagnostic aspects of autoantibodies against myeloperoxidase. Clin Nephrol 1992; J7: 161-168.
Guillevin L, Lhote F. Distinguishing polyarteritis nodosa from microscopic polyangiitis and implications for treatment. Curr Opin Rheumatol 1995; 7: 20-24.
Braun MG, Csernok E, Schmitt WH, Gross WL. lncidence, target antigens, and clinical implications of antineutrophil cytoplasmic antibodies in Reumatoid Arthritis. J Rheumatol 1996; 23: 826-830.
Homas PB, David-Bajar KM, Fitzpatrick JE et al. Microscopic Polyarteritis. Arch Dermatol 1992; 128: 1223-1228.
Niles JL, Bõttinger EP, Saurina GR et ai. The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. Arch lntern Med 1996; 156: 440-445.
Specks U, Wheatley CL, McDonald TJ, Rohrbach MS, DeRemee RA. Anticytoplasmic autoantibodies in the diagnosis and follow up of Wegener's granulomatosis. Mayo Clin Proc 1989; 64: 28- 36.
Tervaert JWC, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, et ai. Association between aclive Wegener's granulomatosis and anticytoplasmic antibodies. Arch lntern Med 1989; 149: 2461-2465.
Gross WL, Schmitt WH, Csernok E. ANCA and associated d1seases: immunodiagnostic and pathogenetic aspects. Clin Exp lmmunol 1993; 93: 1-12.
Moder KG. Use and interpretation of Rheumatologic Tests: a guide for clinicians. Mayo Clin Proc 1996; 71: 391-396.
Davenport A. False positive perinuclear and cyloplasmic anti neutrophil cytoplasmic antibody results leading to misdiagnosis of Wegwner's granulomatosis and/or microscopic polyarteritis. Clin Nephrol 1992; 37: 124-130.
DeClerck LS, Van Offel JF, Smolders WA, Empsten FA, Bridts CH, Bourgeois N et ai. Pitfalls with anti-neutrophil cytoplasmic antibodies (ANCA). Clin Rheumatol 1989; 8: 512-516.
Mustonen J, Soppi E, Pasternack A, Hallstrom O. Clinical significance of autoantibodies against neutrophil cytoplasmic components in patients with renal disease. Am J Nephrol 1990; 10: 482-488.
Andrassy K, Koderisch J, Rufer M, Erb A, Waldherr R, Ritz E. Detection and clinicai implication of anti-neutrophil cytoplasmic antibodies in Wegener's granulomatosis and rapidly progressive glomerulonephritis. Clin Nephrol 1989; 32: 159-167.
Rao JK, Weinberger M, Oddone EZ, Allen NB, Landsman P, Feussner JR. The role of antineutrophil cytoplasmic antibody (c ANCA) testing in the diagnosis of Wegener granulomatosis: a literature and meta-analysis. Ann lntern Med 1995; 123: 925-932.
Collins DA, Bourke BE. Antigen specificity of ANCA in systemic vasculitis. (letter) Br J Rheumatol 1995; 34: 394.
Falk RJ, Jennette J. Antineutrophil cytoplasmic antibodies with specificity for myeloperoxidase in patients with systemic vasculllis and idiopathic and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-1657.
Tervaert JWC, Goldschmeding R, Elema JD, Von Dem Borne AE, Kallenberg CG. Antimyeloperoxidase antibodies in lhe Churg Strauss syndrome. Thorax 199 I; 46: 70-71.
Kallenberg CGM, Mulder AHL, Tervaert JWC. Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders. Am J Med 1992; 93: 675-681.
Lesavre P, Noel LH, Gayno S et ai. Atypical autoantigen targets of perinuclear antineutrophil cytoplasm antibodies (p-ANCA) specificity and clinical associations. J Autoimmunity 1993; 6: 185-195.
Cohen P, Guillevin L, Baril L, Lhote F, Noel LH, Lesavre P. Persistence of antineutrophil cytoplasmic antibodies (ANCA) in asymptomatic patients with systemic polyarteritis nodosa or Churg-Strauss syndrome: follow-up of 53 patients. Clin Exp Rheumatol 1995; 13: 193-198.
Specks U, DeRemee RA. Granulomatous vasculitis, Wegener's granulomatosis and Churg-Strauss syndrome. Rheum Dis Clin North Am 1990; 16: 377-397.
Guillevin L, Visser H, Noel LH, Pourrat J, Vernier 1, Gayraud M, Oksman F, Lesavre P. Antineutrophil cytoplasm antibodies (ANCA) in systemic polyarteritis nodosa with and without hepatitis B virus infection and Churg-Strauss syndrome. Sixty two patients. J Rheumatol I 993; 20: 1345-1349.
Geffriaud-Ricouard C, Noel LH, Chaveau D, Houhou S, Grunfeld JP, Lesavre P. Clinical spectrum associated with ANCA of defined antigen specificities in 98 selected patients. Clin Nephrol 1993; 39: 125- I 36.
Falk RJ. ANCA-associated renal disease. kidney lnt 1990; 38: 998-1010.
Edgar JDM, McMillan SA, Bruce fN, Conlan SK. An audit of ANCA in routine clinicai practice. Postgrad Med J 1995; 71: 605- 612.
Tervaert JWC, Huitema MG, Hene RJ et ai. Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre. Lancei 1990; 336: 709-711.
Saxon A, Shanchan F, Landers C et al. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin lmmunol I 990; 86: 202-210.
Rump JA, Scholmerich J, Gross V et ai. A new type of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in aclive Ulcerative Colitis but not in Crohn's disease. lmmunology 1990; 181: 406-413.
Feigenbaum PA, Medsger TA Jr, Kraines RG, Fries JF. The variability of immunologic laboratory tests. J Rheumatol 1982; 9: 408-414.
Unsworth DJ, Tomson CRV, Lock RJ, Wallington TB, Feest TG. e-ANCA as a marker of Wegener's disease. (letter) Lancet 1996; 347: 115-116.
Kerr GS, Fleisher TA, Hallahan CW, Leavitt RY, Fauci AS, Hoffman GS. Limited prognostic value of changes in antineutrophil cytoplasm antibody titer in patients with Wegener's granulomatosis. Arthritis Rheum 1993; 36: 365-371.
Hoffman GS, Kerr GS. Rise in ANCA titter: to treat or not to treat? (letter) Am J Med 1995; 98: 102-103.
Csernok E, Gross WL. lmmunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. Curr Opin Rheumatol 1995; 7:11-19.
Dolman KM, Stegeman CA, Van de Wiel BA, Hack CE, von dem Borne AEG, Kallenberg CGM, Goldschmeding R. Relevance of classic anti-neutrophil cytoplasmic autoantibody (c-ANCA) mediated inhibition of proteinase 3-alpha-1-antitrypsin complexation to disease activity in Wegener's granulomatosis. Clin Exp lmmunol 1993; 93: 405-410.
Mandell BF, Hoffman GS. Differentiating the vasculitides. Rheum Ois Clin North Am 1994; 20: 409-442.
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