Imunologia da Doença por Coronavírus-19 (COVID-19): Uma Perspetiva Para o Clínico, nos Primeiros 4 Meses da Emergência do SARS-CoV-2

Autores

  • Luís Delgado Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Portugal; CINTESIS, Centro de Investigação em Tecnologias e Serviços de Saúde, Universidade do Porto, Porto, Portugal https://orcid.org/0000-0003-2375-9071
  • José Laerte Boechat Serviço de Imunologia Clínica, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal Fluminense, Niterói/ RJ, Brasil; Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Portugal https://orcid.org/0000-0002-9738-8210
  • Inês Chora Serviço de Medicina Interna, Departamento de Medicina, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Senhora da Hora, Matosinhos, Portugal; Faculdade de Medicina, Universidade do Porto, Porto, Portugal https://orcid.org/0000-0003-4750-2326

DOI:

https://doi.org/10.24950/rspmi/COVID19/FMUP/S/2020

Palavras-chave:

Coronavírus, Infecções por Coronavírus, Imunopatologia, Pandemia

Resumo

Nos quatro meses desde a emergência duma infeção pandémica por uma nova estirpe altamente patogénica de coronavírus beta em humanos, a COVID-19, assistimos a uma rápida partilha nas plataformas digitais das mais diversas publicações científicas, numa experiência que se vive também pela primeira vez na comunidade internacional. Neste trabalho, fazemos uma revisão descritiva das mais recentes informações sobre a imunobiologia do SARS-CoV-2, focando as hipóteses que suportam uma deficiência nos mecanismos da imunidade inata e adquirida ao vírus, e o contributo de uma resposta imunitária disfuncional na progressão e mortalidade associadas à doença. Com base nessa nova informação, apontamos as principais estratégias imunológicas nas terapêuticas dirigidas ao vírus, à resposta imune disfuncional e à profilaxia da infeção (imunização). O aprofundar do conhecimento sobre as interações patogénio-hospedeiro, abrirá o caminho para identificar as melhores estratégias para o diagnóstico, terapêutica e controlo da COVID-19, bem como para a sua prevenção.

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Delgado L, Laerte Boechat J, Chora I. Imunologia da Doença por Coronavírus-19 (COVID-19): Uma Perspetiva Para o Clínico, nos Primeiros 4 Meses da Emergência do SARS-CoV-2. RPMI [Internet]. 21 de Dezembro de 2021 [citado 7 de Dezembro de 2022];. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/248

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