Immunology of Coronavirus-19 Disease (COVID-19): A Perspective for the Clinician in the First 4 Months of the Emergence of SARS-CoV-2
DOI:
https://doi.org/10.24950/rspmi/COVID19/FMUP/S/2020Keywords:
Coronavirus, Coronavirus Infections, COVID- 19, Immunopathology, PandemicsAbstract
In the last four months, since the emergence of a pandemic infection by a new highly pathogenic strain of beta coronavirus in humans, COVID-19, we have witnessed the fast sharing on digital platforms of the most diverse scientific publications, an experience also lived for the first time by the international medical community. In this review of the latest information on SARS-COV-2 immunobiology, we focused on the hypotheses that support a defective innate and acquired immunity to the virus, and the contribution of a dysfunctional immune response for the progression and mortality associated with the disease. Based on this new information, we point out the main immunotherapy strategies targeting the virus, the dysfunctional immune response and the disease prophylaxis (immunization). Improving our knowledge on the pathogen-host interactions will open the way to identify the best strategies for the diagnosis, treatment and control of COVID-19, as well as to the best preventive measures.
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