JC Virus Granule Cell Neuronopathy in HIV Patient with Immune Recovery: Case Report
DOI:
https://doi.org/10.24950/rspmi.2672Keywords:
Cerebellar Diseases, HIV, JC Virus, Leukoencephalopathy, Progressive MultifocalAbstract
The reactivation of JC virus infection is typically associated with progressive multifocal leukoencephalopathy (PML) in patients with severe immune deficiency, particularly in the context of human immunodeficiency virus (HIV) infection. However, other neurological complications are possible, such as JCV granule cell neuronopathy, a clinical syndrome first described in 2005 with notable tropism for the cerebellum. We describe the case of a male HIV patient with a past diagnosis of PML followed by adequate immune recovery and undetectable viral load under antiretroviral therapy, who developed progressive cerebellar syndrome. The authors highlight the challenges posed to the diagnosis and management of this lesser known JC virus-related disease.
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