Pharmacogenomics in clinical practice: example of HLA-B*5701 and abacavir hypersensitivity reaction
Keywords:
pharmacogenomics, HLA-B*5701, AbacavirAbstract
Pharmacogenomics is the study of variation in the characteristics
of nucleic acids relating with response to drugs. It is considered
crucial to the development of individualized Medicine. Adverse
reactions to drugs increase morbidity, mortality and healthcare
costs. Pharmacogenomics holds the potential to reduce drugs
adverse reactions. HIV infected patients have a higher incidence
of hypersensitivity reactions. Abacavir is a reverse transcriptase
nucleoside inhibitor used in the treatment of HIV infection, but
causes hypersensitivity reactions in 5 to 8% of the patients. There
has been a link of HLA-B*5701 with abacavir hypersensitivity reaction and the analysis of HLA-B*5701 may reduce the incidence
of this hypersensitivity reaction.
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