Association between pernicious anemia and gastric carcinoid tumor: a report of a clinical case
Keywords:
Pernicious anemia, gastric carcinoid tumorsAbstract
Gastric carcinoid tumors are uncommon, representing ≤ 1%
of gastric tumors and 8, 7% of all gastrointestinal carcinoid tumors.
Therefore, the authors present a case of a 32 year old woman,
admitted in an Internal Medicine ward, for macrocytic anemia and
whose etiological research revealed a pernicious anemia (PA). An upper gastrointestinal endoscopy revealed 6 polyps in the upper
body of the stomach. All polyps were diagnosed as carcinoid
using endoscopic biopsies. After exclusion of metastasis (by CT
scan and Octreotid scan), and taking into account the multifocal
involvement of the tumor and the presence of complete intestinal
metaplasia in the gastric body, the patient was proposed for total
gastrectomy held without complications. It is under treatment with
vitamin B-12, with excellent clinical and analytical response.
The presentation of this case alerts to the risk of the appearance of gastric carcinoid tumors in patients with PA and the
need for upper endoscopy immediately after the diagnosis of the
same. In gastric carcinoids type I, with no metastasis, the trend
is benign.
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References
ModlinIM, Lye KD et al. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97:934-959.
Gilligan CJ, Lawton GP et al. Gastric carcinoid tumors: the biology and therapy of an enigmatic and controversial lesion. Am J Gastroenterol
;90:338-352.
Granberg D, Wilander et al. Clinical symptoms, hormone profiles, treatment and prognosis in patients with gastric carcinoids. Gut 1998;43:223-228.
Rindi G, Luinetti O et al. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: A clinicopathologic study. Gastroenterology 1993; 104: 994-1006.
Berger MW, Stephens DH. Gastric carcinoid tumors associated with chronic hypergastrinemia in a patient with Zollinger-Ellison syndrome. Radiology 1996; 201: 371-373.
Bordi C, D’adda T et al. Pathogenesis of ECL cell tumors in humans. Yale J Biol Med 1998; 71: 273-284.
Dakin F.G., Warner R et al. Presentation, treatment and outcome of type 1 gastric carcinoid tumors. Journal of Surgical Oncology 2006; 93:368-372.
Jordan PH jr, Barroso A et al. Gastric carcinoids in patients with hypergastrinemia. J Am Coll Surg 2005; 199:552-555.
Kadikoylu G, Yavasoglu I et al. Treatment of solitary gastric carcinoid tumor by endoscopic polypectomy in a patient with pernicious anemia. World J Gastroenterol 2006; 12(26): 4267-4269.
Binstock A, Johnson C et al. Carcinoid tumors of the stomach: a clinical and radiographic study. AJR 2001; 176:947-951
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