Mononeuropathy multiplex in a Churg-Strauss syndrome patient – case report
Keywords:
Churg-Strauss syndrome, ANCA-associated vasculitis, mononeuropathy multiplexAbstract
A 44 year-old male with asthma and allergic to grass pollen came
to our Emergency Department with dyspnea, productive cough,
paresthesia, dysaesthesia and dysphonia. He was admitted with
a diagnosis of community-acquired pneumonia. An acute axonal
polyneuropathy has developed preventing the patient from walking
becoming totally dependent on others. In spite of exhaustive
investigation the aetiology was not ascertained. Peripheral blood
eosinophilia and P-ANCA positivity with myeloperoxidase specificity led to the diagnostic hypothesis of ANCA associated vasculitis,
namely Churg-Strauss syndrome. Treatment with prednisolone
and cyclophosphamide achieved significant improvement, albeit
a disabling neuropathy persisting and not responding well to
intravenous immunoglobulin and rituximab.
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