Thorotrast related hepatic malignancies – two case reports

Authors

  • Alexandra Bayão Horta Serviço 2 de Medicina Interna do Hospital de Santo António dos Capuchos, Lisboa
  • Maria J. Goes Serviço 2 de Medicina Interna do Hospital de Santo António dos Capuchos, Lisboa
  • Susana Oliveira Serviço 2 de Medicina Interna do Hospital de Santo António dos Capuchos, Lisboa
  • António Santos Castro Serviço 2 de Medicina Interna do Hospital de Santo António dos Capuchos, Lisboa

Keywords:

thorotrast, thorium dioxide, cholangiocarcinoma

Abstract

The A.A. report two cases of thorotrast related hepatic malignancies, two cholangiocarcinomas, observed in an Internal Medicine ward at a hospital in Lisbon. A comment is made about
the effects of ionizing radiation on the human body, taking special attention to those caused
by thorotrast. We comment on the long period of time between the thorotrast injection and the
diagnosis of the tumour, as well as the fact that
these are probably the last cases of thorotrast related tumours.

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References

Levy DW, Rindsberg S, Friedman AC et al. Thorotrast-Induced Hepatosplenic Neoplasia: CT Identification. AJR 1986;146: 997-1004.

Yuji Ito, Masamichi Kojiro, Toshiro Nakashima, Takesaburo Mori. Pathomorphologic characteristics of 102 cases of thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma. Cancer 1988;62:1153-1162.

Vaz Serra A, Correia Trincão R.. Hemangioendotelioma maligno hepático 30 anos após arteriografia pelo torotraste. Arquivos de patologia geral e anatomia patológica 1962; 77-113.

Michael Fry RJ. Principles of carcinogenesis: Physical. In: Devita VT. Jr, Hellman S, Rosenberg SA, eds. Cancer Principles and practice of

oncology. Philadelphia: Lippincot 1989:136-148.

Silva Horta J, Cayolla da Motta L, Tavares MH. Thorium dioxid effects in man, epidemiological, clinical and pathological studies (experience

in Portugal). Environmental Research 1974;8:131-159.

Kojiro M, Kawano Y, Kawasaki H, Nakashima T, Ikezaki H.. Thorotrast-induced hepatic angiosarcoma, and combined hepatocellular and

cholangiocarcinoma in a single patient. Cancer 1982;49:2161-2164.

Masbou J, Valmary J, Bili H et al. Cholangiocarcinome hépatique et fibrosarcome osseux synchrones 45 ans aprés injection de thorotrast.

Gastroenterol Clin Biol 1995;19:120-122.

Silva Horta J, Cayolla da Motta L, Abbat JD, Roriz ML. Malignancy and other late effects following administration of thorotrast. Lancet

;201-205.

Saragoça A, Tavares MH, Barros FB, da Silva Horta J. Some clinical and laboratory findings in patients injected with thorium dioxid. Study of 155 cases. Am J Gastroenterol 1972 ;57(4):301-310.

Rubel LR, Ishak KG. Thorotrast-associated cholangiocarcinoma. An epidemiologic and clinicopathologic study. Cancer 1982;50:1408-1415.

Egas Moniz. Avantages de l’epreuve angiographique dans la carotide primitive. Clínica, Higiene e Hidrologia 1935;9:333-345.

Additional Files

Published

2003-09-30

How to Cite

1.
Horta AB, Goes MJ, Oliveira S, Santos Castro A. Thorotrast related hepatic malignancies – two case reports. RPMI [Internet]. 2003 Sep. 30 [cited 2024 Dec. 18];10(3):143-6. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1814

Issue

Vol. 10 No. 3 (2003): Julho/ Setembro

Section

Case Reports

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