Haemolytic anaemia and myasthenia gravis
Keywords:
cryoglobulin induced haemolytic anaemia and myasthenia gravis, direct antiglobulin test, myasthenia gravis, antibodyAbstract
The authors present the case of a healthy 16 year old caucasian female, who complained of weakness, headaches, dizziness and tachycardia in February of 1993. Clinical examination revealed accentuated pallor.
Laboratory values were compatible with a cryoglobulin induced haemolytic anaemia. She was treated with prednisolone. After 8 days of corticotherapy, and clinical improvement, she was discharged from hospital.
Sixteen months later the clinical symptoms returned with weakness, exhaustion, diplopia, without haemolysis but with leucopenia. Neurological examination was compatible with the diagnosis of myasthenia gravis. is diagnosticated. The thymus was surgically removed and histology revealed lymphoid hyperplasia. The patient started pyridostigmine bromide.
Presently the patient is clinically well, but continues to have a leucopenia with lymphocytosis. ln reference to this case, the authors comment on cryoglobulin induced haemolytic anaemia and myasthenia gravis, it's rarity and coexistence in a patient with immunological disorders.
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References
Lobo IM. Anemia Hemolítica Autoimune. Diagnóstico e estudo lmuno-hematológico. Cadernos do Generalista 1993; 119: 31-36.
Cai JR, Zhang FQ. Autoimmune Hemolytic Anemia. clinical analisys of 100 cases. Chunh Hua nei Ko Tsa Chih 1989; 28: 670-673.
Kajii E, Ikemoto S. A Cold Aglutinin. Om Vox Sang 1989; 56: 104- 106.
Richard A, Cooper H, Franklin Bunn. Anemias Hemoliticas. Jean D. Wilson. Eugene Braunwald. Kurt J. lsselbacher, Robert G. Petersdorf. Joseph B. Martin. Anthony s. Fauci. Richard K. Root eds. Harrison Pricípios de Medicina Interna. 12 Edicion, Vol 2, Inter Americana McGraw - Hill. Madrid 1991 1776-1789.
Engel AG. Banker BQ, Nelson TC et ai. Distúrbio da Transmissão Neuromuscular (509). James B, Wyngaarden MD, Bennett J. Claude eds. Cecil Tratado de Medicina Interna, 19" edição, Guanabara Koogan, Rio de Janeiro 1993: 2313-2316.
Banford C. Myasthenia gravis. Carroll C. Cann ed. The 5 Minute Consult, A Waverly Campany, USA 1994: 656-657.
Yasuo Iwasaki,. and Maso Kinoshite. Ocular Myasthenia Gravis Associated with Autoimmune Hemolytic Anemia and Hashimoto's Thyroiditis. Am J Ophlhalmol 1989; 107( 1 ):90-91.
Kameoko J, Endo K, Sugawara T et al. Autoimune hemolytic anemia and myasthenia gravis. Jpn J Med 1991; 30: 330-332.
Andrea DV, Malinovsky L, Ambrogi M et al. Thymectomy as treatment of autoimune diseases other than myasthenia gravis. Thymus 1993; 21: 1-10.
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