Disulfiram intoxication - Diffuse anoxic leucoencephlopathy
Keywords:
disuifiram, intoxication, diffuse anoxic leukoencephalopathy, carbon disuifideAbstract
Disuifiram can be used as adjuvant terapeutic in the management of some selected cases of cronic alcoholic dependence, causing extreme disconfort in the course of drinking alcoholic beve rages.
The authors present a case report of leucoence falopathy, periferal neuropathy and hyponatremia in an alcoholic patient, and discuss the relations between those adverse reaction and the intoxicati on with disuifiram and it's metabolite, carbon disuifide.
Downloads
References
B. G. Katzung. in:Basic & Clinical Pharmacology: Lange medical Publication 1982:231-238.
American Hospital Formulary Service-Drug Information 1991: Unclassified Therapeutic Agents-Disulfiram:2169-2171.
D. Laplane, N. Atrai, B. Sauron, A. De Billy, B. Dubois: Lesions of basal ganglia due to disulfiram neurotoxicity. Jornal of Neurology, Neurosurgery and Psychiatry 1992; 55:925-929.
J. M. Bruncher: Leukoencephalopathies in anoxic-ischemic processes, Handbook of Clinic neurology Vol 3 ( 47); Demyelina ting Diseases 1985.
Hekkila RE, Cabbat FS, Cohen G. ln vivo inhibition of superoxide dismutase im mice by diethildithiocarbamate. J Biol Chem 1976; 251: 2182.
Knee ST, Razani J. Acute organic brain syndrome: a complication of disulfiram therapy. Am J Psychiatry 1974; 131:1281-1282
Kane FJ Jr. Carbon disulfide intoxication from overdosage of di sulfiram Am J Psychiatry 1970; 127: 690 - 694.
Borret D, Ashby P, Bilbao J, Carlen P. Reversible late onset disulfi ram-induced neuropathy and encephalopathy. Ann Neurol 1985; 17: 396-399.
Fisher CM: "Catatonia" dueto disulfiram toxicity. Arch Neurol 1089; 46: 798-804.
Hotson JR, Langston JW. Disulfiram-induced encephalophaty, Arch Neurol 1976; 33: 141-142.
Ansbacher LE, Bosch P, Cancilla PA. Disulfiram neuropathy: a neurofilamentous distal axonopathy. Neurology 1982; 32: 424-428.
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 1995 Internal Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna