Use of venous thromboprophylaxis and compliance with institutional guidelines: A cross-sectional study

Authors

  • A.R. Francisco Serviço de Medicina Interna do Centro Hospitalar de Setúbal, E.P.E.
  • V. Figueiredo Serviço de Medicina Interna do Centro Hospitalar de Setúbal, E.P.E.
  • J. Barroca Serviço de Medicina Interna do Centro Hospitalar de Setúbal, E.P.E.
  • S. Serra Serviço de Medicina Interna do Centro Hospitalar de Setúbal, E.P.E.
  • E. Pedroso Serviço de Medicina Interna do Centro Hospitalar de Setúbal, E.P.E.

DOI:

https://doi.org/10.24950/rspmi.976

Keywords:

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Abstract

Venous thromboembolism (VTE) is a very serious and common
complication of hospitalization. All inpatients have an increased
risk for VTE and there are several measures that can be used to
prevent it. International guidelines recommend their use both in
surgical patients as in medical patients. The aim of this study
was to assess compliance with thromboprophylaxis institutional
guidelines.
A cross-sectional study was carried out in a Portuguese Hospital
three years after guidelines were implemented there. For each patient, in the different departments for acute conditions, the authors
studied the individual risk and the global guideline compliance.
Out of 234 inpatients at the hospital, 25 were excluded. The
patients were divided in two groups according to their condition
being primarily a medical or surgical one. In our sample 80.4% of
patients presented moderate/high risk of VTE. The compliance rate
with institutional guidelines was: 75.3%; and 86.6% (in medical
and surgical patients, respectively); reflecting a better compliance
than reported in previous literature. However in patients at risk
for VTE and heparin use contraindications only 9.7% underwent
mechanical prophylaxis. This last issue represents an important
field for future improvement.
Key words: Venous thromboembolism; deep vein thrombosis;
pulmonary embolism; low-molecular weight heparin.

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References

Geerts WH, Bergqvist D, Pineo, et al. Prevention of venous thromboembolism. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133(6 Suppl):381S-453S.

Francis CW. Prophylaxis for thromboembolism in hospitalized medical patients. N Engl J Med 2007; 5 356(14):1438-44. Erratum in: N Engl J Med 2007; 12;357(2):203.

Turpie AG. Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in MEDical patients with ENOXaparin (MEDENOX) trial. Am J Cardiol 2000; 28;86(12B):48M-52M.

Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation 2003; 17; 107(23 Suppl 1):I9-16.

Alikhan R, Peters F, Wilmott R, Cohen AT. Fatal pulmonary embolism in hospitalised patients: a necropsy review. J Clin Pathol 2004; 57: 1254–1257.

Kanaan AO, Silva MA, Donovan JL, Roy T, Al-Homsi AS. Meta-analysis of venous thromboembolism prophylaxis in medically Ill patients. Clin Ther2007; 29(11):2395-405.

Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson FA Jr; ENDORSE Investigators. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 2008; 2;371(9610):387-94. Erratum in: Lancet 2008; 7;371(9628):1914.

Sullivan SD, Kahn SR, Davidson BL et al. Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopaedic surgery. Pharmacoeconomics 2003; 21(7):477-496.

Schädlich PK, Kentsch M, Weber M, et al. Cost effectiveness of enoxaparin as prophylaxis against venous thromboembolic complications in acutely ill medical inpatients: modelling study from the hospital perspective in Germany. Pharmacoeconomics 2006; 24(6):571-591.

Offord R, Lloyd AC, Anderson P, Bearne A. Economic evaluation of enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients. Pharm World Sci 2004; 26(4):214-220.

Otero R, Uresandi F, Cayuela A, et al. Use of venous thromboembolism prophylaxis for surgical patients: a multicentre analysis of practice in Spain. Eur J Surg 2001; 167(3):163-167.

Yu HT, Dylan ML, Lin J, Dubois RW. Hospitals' compliance with prophylaxis guidelines for venous thromboembolism. Am J Health Syst Pharm2007; 1;64(1):69-76.

Amin A, Stemkowski S, Lin J, Yang G. Thromboprophylaxis rates in US medical centers: success or failure? J Thromb Haemost 2007; (8):1610-1616.

Tapson VF, Decousus H, Pini M, et al. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest 2007; 132(3):936-945.

Cunha F, Bragança I, Rocha V, Carvalho C. Procedimento para Prevenção de Tromboembolias Venosas. 2007 Procedimento do Centro Hospitalar de Setúbal, EPE. Est 11.

Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(3 Suppl):338S-400S.

Vallano A, Arnau JM, Permanyer G, et al. Use of venous thromboprophylaxis and adherence to guideline recommendations: a cross-sectional study. Thrombosis Journal 2004, 2:3.

Keane MG, Ingenito EP, Goldhaber SZ. Utilization of venous thromboembolism prophylaxis in the medical intensive care unit. Chest 1994; 106:13-14.

Lepaux DJ, Charpentier C, Pertek JP, et al. Assessment of deep vein thrombosis prophylaxis in surgical patients: a study conducted at Nancy University Hospital, France. Eur J Clin Pharmacol 1998, 54:671-676.

Stratton MA, Anderson FA, Bussey HI, Caprini J, et al. Prevention of venous Thromboembolism. Adherence to the 1995 American College of Chest Physicians Consensus Guidelines for surgical patients. Arch Intern Med 2000; 160:334-340.

Riskpam RP, Trottier SJ. Utilization of venous thromboembolism prophylaxis in a medical-surgical ICU. Chest 1998; 113:162-164.

Magy-Bertrand N, Auzas O, Meaux-Ruault N, et al. Thromboprophylaxis assessment in an internal medicine department.. Rev Med Interne 2010; 31(6):406-10.

Additional Files

Published

2014-03-31

How to Cite

1.
Francisco A, Figueiredo V, Barroca J, Serra S, Pedroso E. Use of venous thromboprophylaxis and compliance with institutional guidelines: A cross-sectional study. RPMI [Internet]. 2014 Mar. 31 [cited 2024 Nov. 21];21(1):5-12. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/976

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