O Impacto da Dieta Vegetariana no Risco Cardiovascular
DOI:
https://doi.org/10.24950/Revisao/66/19/1/2020Palavras-chave:
Dieta Vegetariana, Doenças Cardiovasculares, Fatores de Risco, VegetarianosResumo
Introdução: A doença cardiovascular é uma causa major de morbimortalidade, pelo que otimizar a sua prevenção e gestão continua a ser uma prioridade. Este artigo de revisão tem em vista providenciar uma análise crítica dos aspetos positivos e negativos acarretados por uma dieta vegetariana no risco cardiovascular.
Resultados: Em geral, a população vegetariana apresenta melhor perfil cardiovascular, com valores mais adequados de índice de massa corporal, perfil lipídico e superior controlo tensional e glicémico. Novos mecanismos aterogénicos parecem ser também influenciados como a remoção dos remanescentes de quilomicrons da circulação, o estado inflamatório e oxidativo e a microbiota intestinal. Adicionalmente, métodos de imagem demonstraram características estruturais e funcionais vasculares mais favoráveis em vegetarianos. No entanto, uma dieta vegetariana desequilibrada pode conduzir a défices nutricionais. Estes podem ser facilmente ultrapassados através de um plano nutricional completo e variado, e eventualmente recorrendo a suplementos e alimentos fortificados. Acima de tudo, um efeito benéfico do vegetarianismo estará sempre associado a uma dieta vegetariana equilibrada, com base em alimentos saudáveis, e escassez de produtos alimentícios processados, açúcares refinados e gorduras trans.
Conclusão: A dieta vegetariana resulta em impactos positivos em vários fatores de risco cardiovascular independentes. Apesar do desafio acrescido em obter macro e micronutrientes necessários que possam estar menos disponíveis em alimentos de origem vegetal, o seu défice pode ser evitado através de uma dieta planeada, alicerçada em alimentos naturais e saudáveis. Havendo noção das suas limitações e tomadas as devidas providências, uma dieta vegetariana pode ser utilizada eficientemente contra a doença cardiovascular.
Downloads
Referências
Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017;70):1–25. doi: 10.1016/j.jacc.2017.04.052.
Bryan NS. Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease. Curr Atheroscler Rep [Internet]. 2018;20:21. doi:10.1007/s11883-018-0723-0%0A
Dinu M, Pagliai G, Sofi F. A Heart-Healthy Diet: Recent Insights and Practical Recommendations. Curr Cardiol Rep. 2017;19 :95. doi: 10.1007/s11886-017-0908-0.
Widmer RJ, Flammer AJ, Lerman LO, Lerman A. The Mediterranean diet, its components, and cardiovascular disease. Am J Med. 2015;128:229–38. doi:10.1016/j.amjmed.2014.10.014
Dinu M, Pagliai G, Casini A, So F. Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. Eur J Clin Nutr. 2017;72:30–43. doi: 10.1038/ejcn.2017.58.
Dinu M, Abbate R, Gensini GF, Casini A, Sofi F. Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of obser- vational studies. Crit Rev Food Sci Nutr [Internet]. 2017;57:3640–9. doi:10. 1080/10408398.2016.1138447
Vinagre JC, Vinagre CCG, Maranha RC. Plasma kinetics of chylomicron-like emulsion and lipid transfers to high-density lipoprotein (HDL) in lacto-ovo vegetarian and in omnivorous subjects. Eur J Nutr. 2014;53:981–7.
Harris WS. Achieving optimal n–3 fatty acid status: the vegetarian’s challen- ge... or not. Am J Clin Nutr. 2014;100:449–52.
Patel H, Chandra S, Alexander S, Soble J, Allan K, Sr W. Plant-based nutrition: an essential component of cardiovascular disease prevention and management. Curr Cardiol Rep. 2017;19:104. doi: 10.1007/s11886-017- 0909-z.
Chiu YF, Hsu CC, Chiu THT, Lee CY, Liu TT, Tsao CK, et al. Cross-sectional and longitudinal comparisons of metabolic profiles between vegetarian and non-vegetarian subjects: A matched cohort study. Br J Nutr. 2015;114:1313–20.
Navarro JA, de Gouveia LA, Rocha-Penha L, Cinegaglia N, Belo V, Castro MM de, et al. Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men. Clin Chim Acta. 2016;461:110–3. doi:10.1016/j.cca.2016.08.002
Spector R. New insight into the dietary cause of atherosclerosis: implications for pharmacology. J Pharmacol Exp Ther. 2016;358:103–8. doi: 10.1124/jpet.116.233296.
Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. Eur Hear J. 2016;37:2315–81. doi: 10.1093/eurheartj/ehw106.
Wang F, Zheng J, Yang B, Jiang J, Fu Y, Li D. Effects of vegetarian diets on blood lipids: A systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2015;4 :e002408. doi: 10.1161/ JAHA.115.002408.
Kahleova H, Levin S, Barnard N. Cardio-metabolic benefits of plant-based diets. Nutrients. 2017;9: E848. doi: 10.3390/nu9080848.
Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: A presidential advisory from the American Heart Association. Circulation. 2017;136:e1–e23. doi: 10.1161/CIR.0000000000000510.
Bernstein AM, Sun Q, Hu FB, Stampfer MJ, Manson JE, Willett WC. Major dietary protein sources and risk of coronary heart disease in women. Circulation. 2010;122:876–83.
Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: A meta-analysis of randomised controlled studies. Br J Nutr. 2014;112:214–9.
Bazzano LA, Thompson AM, Tees MT, Nguyen CH, Winham DM. Non-soy legume consumption lowers cholesterol levels: A meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2011;21:94–103. doi:10.1016/j.numecd.2009.08.012
Zhang Z, Wang J, Chen S, Wei Z, Li Z, Zhao S, et al. Comparison of vegeta- rian diets and omnivorous diets on plasma level of HDL-c: A meta-analysis. PLoS One. 2014;9 :e92609. doi: 10.1371/journal.pone.0092609.
Wright N, Wilson L, Smith M, Duncan B, Mchugh P, Wright N. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes. 2017;7:256–66. doi:10.1038/nutd.2017.3
Burns-whitmore B, Haddad E, Sabaté J, Rajaram S. Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians : a randomized , crossover, free-living intervention study. Nutr J. 2014;13:29. doi: 10.1186/1475- 2891-13-29.
Vinagre JC, Vinagre CG, Pozzi FS, Slywitch E, Maranha RC. Metabolism of triglyceride-rich lipoproteins and transfer of lipids to high-density lipopro- teins ( HDL ) in vegan and omnivore subjects. Nutr Metab Cardiovasc Dis. 2013;23:61-7. doi: 10.1016/j.numecd.2011.02.011.
Acosta-Navarro J, Antoniazzi L, Oki AM, Bonfim MC, Hong V, Acosta-Car- denas P, et al. Reduced subclinical carotid vascular disease and arterial stiff- ness in vegetarian men: The CARVOS Study. Int J Cardiol. 2017;230:562–6. doi: 10.1016/j.ijcard.2016.12.058.
Bradbury KE, Crowe FL, Appleby PN, Schmidt JA, Travis RC, Key TJ. Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans. Eur J Clin Nutr. 2013;68:178–83. doi:10.1038/ejcn.2013.248
Trepanowski JF, Varady KA. Veganism is a viable alternative to conventional diet therapy for improving blood lipids and glycemic control. Crit Rev Food Sci Nutr. 2014;55:2004–13.
Chuang S-Y, Chiu THT, Lee C-Y, Liu T-T, Tsao CK, Hsiung CA, et al. Ve- getarian diet reduces the risk of hypertension independent of abdominal obesity and inflammation. J Hypertens. 2016;34:2164–71. doi: 10.1097/HJH.0000000000001068.
Huang R, Huang C, Hu FB, Jorge E. Vegetarian diets and weight reduc- tion: a meta-analysis of randomized controlled trials. J Gen Intern Med. 2016;31:109–16.
Appel LJ. The Effects of Dietary Factors on Blood Pressure. Cardiol Clin. 2017;35:197–212. doi:10.1016/j.ccl.2016.12.002
Ashworth A, Bescos R. Dietary nitrate and blood pressure: evolution of a new nutrient? Nutr Res Rev. 2017;30:208-219. doi: 10.1017/ S0954422417000063.
Pressure B, Stamler J, Brown IJ, Daviglus ML, Chan Q, Miura K, et al. Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure. Am J Clin Nutr. 2013;98:136–45.
Moore CE, Montgomery BD, Najjar RS. A defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications. Clin Cardiol. 2018;41:307–13. doi: 10.1002/clc.22863.
Li G, Zhang P, Wang J, An Y, Gong Q, Gregg EW, et al. Cardiovascular mor- tality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Preven- tion Study: a 23-year follow-up study. Lancet Diabetes Endocrinol. 2014; 2:474-80. doi: 10.1016/S2213-8587(14)70057-9.
The Emerging Risk Factors Collaboration. Diabetes mellitus , fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet Diabetes Endocrinol. 2010;375:2215–22. doi:10.1016/S0140-6736(10)60484-9
Kahleova H, Pelikanova T. Vegetarian diets in the prevention and treatment of type 2 diabetes. J Am Coll Nutr. 2015;34:448–58.
Chiu TH, Pan WH, Lin MN, Lin CL. Vegetarian diet, change in dietary pat- terns, and diabetes risk: a prospective study. Nutr Diabetes. 2018;8:12–25. doi: 10.1038/s41387-018-0022-4.
Tonstad S, Stewart K, Oda K, Batech M, Herring RP, Fraser GE. Vegetarian diets and incidence of diabetes in the Adventist Health Study-2. Nutr Metab Cardiovasc Dis. 2013;23:292–9. doi:10.1016/j.numecd.2011.07.004
Wanders AJ, Alssema M, Koning EJP De, Cessie S, Vries JH De, Zock PL, et al. Fatty acid intake and its dietary sources in relation with markers of type 2 diabetes risk: The NEO study. Eur J Clin Nutr. 2017;71:245–51. doi:10.1038/ejcn.2016.204
Bittner VA. The New 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease Circulation. 2019 (in press). doi:10.1161/CIRCULATIONAHA.119.040625
Kahleova H, Matoulek M, Malinska H, Oliyarnik O, Kazdova L, Neskudla T, et al. Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with type 2 diabetes. Diabet Med. 2011;28:549–59. doi: 10.1111/j.1464-5491.2010.03209.x.
Gyawali P, Richards RS. Association of altered hemorheology with oxi- dative stress and inflammation in metabolic syndrome. Redox Rep. 2015;20:139–45.
Sofi F, Dinu M, Pagliai G, Cesari F, Gori AM, Sereni A, et al. Low-calorie vegetarian versus mediterranean diets for reducing body weight and improving cardiovascular risk profile. Circulation. 2018;137:1103–13. doi: 10.1161/ CIRCULATIONAHA.117.030088.
Szeto YT, Kwok TC, Benzie IF. Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk. Nutrients. 2004;20:863–6.
Naghedi-baghdar H, Nazari S, Taghipour A, Nematy M, Shokri S, Mehri M, et al. Effect of diet on blood viscosity in healthy humans: a systematic re- view. Electron Physician. 2018;10:6563-70. doi: 10.19082/6563.
Tuso P. A Plant-Based Diet, Atherogenesis, and Coronary Artery Disease Prevention. Perm J. 2015;19:62–7.
Rosario VA, Fernandes R, Trindade EBSDM. Vegetarian diets and gut microbiota: important shifts in markers of metabolism and cardiovascular disease. Nutr Rev. 2016;74:444–54.
Rizzo G, Laganà AS, Maria A, Rapisarda C, Maria G, La G, et al. Vitamin B12 among vegetarians: status, assessment and supplementation. Nu- trients. 2016;8:101–24.
Pawlak R. Is vitamin B12 deficiency a risk factor for cardiovascular disease in vegetarians? Am J Prev Med. 2015;48:11–26. doi:10.1016/j.ame- pre.2015.02.009
Wegmüller RSR, Bui CBM, Aeberli IH. Micronutrient status and intake in omnivores, vegetarians and vegans in Switzerland. Eur J Nutr. 2017;56:283– 93.
Basak T, Garg G, Bhardwaj N, Tanwar VS, Seth S, Karthikeyan G, et al. Low holo-transcobalamin levels are prevalent in vegetarians and is as- sociated with coronary artery disease in Indian population. Biomarkers. 2016;21:436–40. doi: 10.3109/1354750X.2016.1153718.
Diets V. Position of the American Dietetic Association: Vegetarian Diets. J Am Diet Assoc. 2009;109:1266–82.
Melina V, Levin S, Craig W. Position of the Academy of Nutrition and Diete- tics: Vegetarian Diets. J Acad Nutr Diet. 2016;116):1970–80.
Tharrey M, Mashchak A, Barbillon P, Delattre M, Fraser GE. Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality: the Adventist Health Study-2 cohort. Int J Epidemiol. 2018;47:1603- 1612. doi: 10.1093/ije/dyy030.
Otero J, Camacho PA, Fornasini M, López-Jaramillo P, Baldeón M. Reeva- luating nutrition as a risk factor for cardiometabolic diseases. Colomb Med. 2018;49:175–81.
Ingenbleek Y, McCully KS. Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis. Nutrition. 2012;28:148–53. doi:10.1016/j.nut.2011.04.009
Sanders TAB. Plant compared with marine n–3 fatty acid effects on car- diovascular risk factors and outcomes: what is the verdict? Am J Clin Nutr. 2014;100:453–8.
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceride- mia. N Engl J Med. 2019;380:11-22. doi: 10.1056/NEJMoa1812792.
Hall WL. The future for long chain n-3 PUFA in the prevention of coronary heart disease: do we need to target non-fish-eaters? Proc Nutr Soc. 2017;76:408–18. doi: 10.1017/S0029665117000428.
Gebauer SK, Psota TL, Harris WS, Kris-etherton PM. n-3 Fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. Am J Clin Nutr. 2006;83:1526–35.
Haehling S Von, Jankowska EA, Veldhuisen DJ Van, Ponikowski P, Anker SD. Iron deficiency and cardiovascular disease. Nat Rev Cardiol . 2015;12:659–69. doi:10.1038/nrcardio.2015.109
Richi EB, Baumer B, Conrad B, Darioli R, Schmid A, Keller U. Health Risks Associated with Meat Consumption: A Review of Epidemiological Studies. Int J Vitam Nutr Res. 2015;85:70–8.
Fang X, An P, Wang H, Wang X, Shen X, Li X, et al. Dietary intake of heme iron and risk of cardiovascular disease: A dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2015;25:24–35.
Mirhosseini NZ, Knaus SJ, Bohaychuk K, Singh J, Vatanparast HA, Weber LP. Both high and low plasma levels of 25-hydroxy vitamin D increase blood pressure in a normal rat model. Br J Nut. 2016;116:1889–900.
Rai V, Agrawal DK. Role of vitamin D in cardiovascular diseases. Endocrinol Metab Clin North Am . 2017;46:1039–59.doi:10.1016/j.ecl.2017.07.009
Ou S, Chen M, Huang C, Chen N. Potential role of vegetarianism on nutritio- nal and cardiovascular status in Taiwanese dialysis patients: a case-control study. PLoS One. 2016;11:e0156297. doi: 10.1371/journal.pone.0156297
Misra R, Balagopal P, Raj S, Patel TG. Vegetarian diet and cardiome- tabolic risk among Asian Indians in the United States. J Diabetes Res. 2018;2018:1675369. doi: 10.1155/2018/1675369.
Satija A, Bhupathiraju SN, Spiegelman D, Chiuve SE, Manson JAE, Willett W, et al. Healthful and unhealthful plant-based diets and the risk of coro- nary heart disease in U.S. adults. J Am Coll Cardiol. 2017;70:411–22. doi: 10.1016/j.jacc.2017.05.047.
Aune D, Giovannucci E, Boffetta P, Riboli E, Vatten LJ, Tonstad S. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all- -cause mortality — a systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol. 2017;46:1029–56.
Brown RC, Id ARG, Tey SL, Chisholm A, Burley V, Id DCG, et al. Associations between nut consumption and health vary between omnivores, vegetarians, and vegans. Nutrients. 2017;9:12–6.
Downloads
Publicado
Como Citar
Edição
Secção
Licença
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição 4.0.
Direitos de Autor (c) 2023 Medicina Interna
Acesso livre