Histiocitose pulmonar de células de Langerhans – a propósito de um caso clínico

Autores

  • António Morais Médico do Internato Complementar do Serviço de Pneumologia, Serviço de Pneumologia do Hospital de São João, Porto
  • Elena Lombardia Médico do Internato Complementar do Serviço de Pneumologia, Serviço de Pneumologia do Hospital de São João, Porto
  • Beatriz Lima Médico do Internato Complementar do Serviço de Pneumologia, Serviço de Pneumologia do Hospital de São João, Porto
  • M. Carmo Palmares Assistente do Serviço de Imunologia da Faculdade de Medicina da Universidade do Porto
  • Conceição Sotto-Moura Assistente do Serviço de Anatomia Patológica, Serviço de Pneumologia do Hospital de São João, Porto

Palavras-chave:

pneumotórax, histiocitose pulmonar, células de Langerhans

Resumo

A histiocitose pulmonar de células de Langerhans é uma doença rara, de etiologia
desconhecida, associada ao consumo tabágico, caracterizada por uma anormal
proliferação de células de Langerhans, com formação de lesões nodulares e de evolução
variável. Os A.A. apresentam o caso clínico de um jovem de 15 anos, internado no
serviço de Pneumologia do Hospital São João, por pneumotórax bilateral. No estudo
clínico efectuado observou-se, na TAC torácica de alta resolução, lesões
predominantemente císticas, 12% de células CD1a+ no LBA e, na biopsia
transbrônquica, nódulos com elevado número de células do tipo histiocitário, com
imunorreactividade positiva para CD1a e S100, obtendo-se o diagnóstico de histiocitose
de células de Langerhans. De seguida e a propósito do caso clínico apresentado,
procede-se a uma análise desta patologia, nomeadamente no que concerne às
características clínicas, radiológicas e patológicas, além do seu diagnóstico e
tratamento.

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Publicado

31-12-2002

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1.
Morais A, Lombardia E, Lima B, Palmares MC, Sotto-Moura C. Histiocitose pulmonar de células de Langerhans – a propósito de um caso clínico. RPMI [Internet]. 31 de Dezembro de 2002 [citado 20 de Dezembro de 2024];9(4). Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1879

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