Recomendações para a Vacinação contra o Herpes Zoster: Documento de Consenso da Sociedade Portuguesa de Medicina Interna e da Associação Portuguesa de Medicina Geral e Familiar

Autores

  • Sofia Duque Assistente Convidada de Geriatria, Instituto de Medicina Preventiva e Saúde Pública, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal https://orcid.org/0000-0001-9273-5650
  • António Marinho Unidade de Imunologia Clínica, Centro Hospitalar e Universitário de Santo António - Porto. UMIB - Unidade Multidisciplinar de Investigação Biomédica do Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto. NEDAI - Núcleo de Estudos de Doenças Autoimunes da Sociedade Portuguesa de Medicina Interna https://orcid.org/0000-0002-3295-6723
  • Paulo Almeida Assistente Hospitalar de Medicina Interna com Competência em Geriatria, Serviço de Medicina Interna, Centro Hospitalar Universitário São João, Porto, Portugal. Membro do Secretariado do Núcleo de Estudos de Geriatria da Sociedade Portuguesa de Medicina Interna, Lisboa, Portugal. Assistente Convidado, Faculdade de Medicina da Universidade do Porto, Porto, Portugal https://orcid.org/0000-0002-4879-559X
  • Raul Marques Pereira Assistente Graduado em Medicina Geral e Familiar, ULSAM - Unidade Local de Saúde do Alto Minho. Assistente Convidado, Escola de Medicina, Universidade do Minho. Diretor Executivo, Centro de Medicina Digital P5, Universidade do Minho. Coordenador, Grupo de Estudos de Dor, Associação Portuguesa de Medicina Geral e Familiar https://orcid.org/0000-0001-8678-4325
  • Rui Buzaco Assistente em Medicina Geral e Familiar com Competência em Geriatria pela Ordem dos Médicos, Clínica CUF Alvalade. Membro da Coordenação do Grupo de Estudos de Saúde do Idoso. https://orcid.org/0000-0003-0181-3081

DOI:

https://doi.org/10.24950/rspmi.1886

Palavras-chave:

Herpes Zoster, Idoso, Nevralgia Pós-Herpética, Vacina contra Herpes Zoster, Vacinação

Resumo

O herpes zoster (HZ), ou zona, é causado pela reativação do vírus varicela zoster latente. Trata-se de uma doença com elevada incidência, associada a grande morbilidade, que pode originar ou agravar uma situação de fragilidade do doente, o que realça a importância da vacinação. Entre os fatores de risco para HZ e nevralgia pós-herpética (NPH), a sua principal complicação, encontram-se a idade, a imunossupressão e a presença de doenças crónicas. A vacinação é uma estratégia eficaz na prevenção do HZ e da NPH. Em Portugal, estão disponíveis duas vacinas contra o HZ: a vacina viva atenuada e a vacina recombinante, a qual apresenta elevada eficácia contra o HZ e suas complicações, especialmente nas populações de maior risco, imunodeprimidas e com imunossenescência que têm contraindicação para a formulação viva atenuada. Contudo, a vacina contra o HZ não consta do Programa Nacional de Vacinação nem existem recomendações nacionais específicas para a imunização. Assim, a Sociedade Portuguesa de Medicina Interna e a Associação Portuguesa de Medicina Geral e Familiar elaboraram um documento de consenso que estabelece orientações para a vacinação contra o HZ.

Recomenda-se a vacinação contra o HZ em todos os adultos com idade igual ou superior a 50 anos, assim como em adultos com idade entre 18 e 49 anos com risco elevado de zona, nomeadamente doentes com comorbilidades médicas ou imunossupressão. Os adultos imunocompetentes devem ser preferencialmente imunizados com a vacina recombinante, podendo receber a vacina viva atenuada em situações pontuais; os adultos imunocomprometidos só podem ser imunizados com a vacina recombinante.

Recomenda-se a vacinação de indivíduos com antecedentes de zona e a imunização com a vacina recombinante de indivíduos previamente vacinados com a vacina viva atenuada. Salienta-se ainda a relevância da promoção da literacia do doente aquando do ato de prescrição da vacina contra o HZ, bem como o papel ativo do médico na sensibilização para a importância da vacinação contra esta patologia

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Referências

Kimberlin DW, Whitley RJ. Varicella–Zoster Vaccine for the Prevention of Herpes Zoster. N Engl J Med. 2007;356:1338-43. doi:10.1056/NEJMct066061

Harpaz R, Ortega-Sanchez IR, Seward JF, Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57:1-30; quiz CE2-4.

Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014;4:e004833-e004833. doi:10.1136/bmjopen-2014-004833

Comissão de Vacinas da Sociedade de Infeciologia Pediátrica e Sociedade Portuguesa de Pediatria. Recomendações sobre vacinas extra Plano Nacional de Vacinação; 2020 [consultado 2 Mai 2023]. Disponível em: https://www.sip-spp.pt/media/jbsn4cvv/recomendac-o-es_vacinas_extra_pnv_sip_28setembro2020.pdf.

Rodrigues I, Barreiro P. Avaliação do programa Nacional de Vacinação – 2o Inquérito Serológico Nacional Portugal Continental 2001-2002. Lisboa: Direção Geral da Saúde: 2006.

Mesquita M, Froes F. Hospital admissions for herpes zoster in Portugal between 2000 and 2010. Acta Med Port. 2013;26:531-6.

Bhavsar A, Lonnet G, Wang C, Chatzikonstantinidou K, Parikh R, Brabant Y, et al. Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States. Open Forum Infectious Diseases. 2022;9:ofac118. doi:10.1093/ofid/ofac118

European Medicines Agency. Shingrix: EPAR - product information; 2020 [consultado 2 Mai 2023]. Disponível em: https://www.ema.europa.eu/ en/documents/product-information/shingrix-epar-product-information_ pt.pdf.

European Medicines Agency. Zostavax: EPAR - product information; 2016 [consultado 2 Mai 2023]. Disponível em: https://www.ema.europa.eu/ en/documents/product-information/zostavax-epar-product-information_ pt.pdf.

Standing Committee on Vaccination (STIKO) at the Robert Koch Institute. Translation of the original Recommendations of the STIKO at the Robert Koch Institute; 2023 [consultado 2 Mai 2023]. Disponível em: https:// www.rki.de/EN/Content/infections/Vaccination/recommandations/04_23_englisch.pdf?__blob=publicationFile.

Bundesministerium für Arbeit, Soziales, Gesundheit und Konsumentenschutz, Nationalen Impfgremiums. Der Impfplan Österreich [Austrian vaccination plan]; 2023 [consultado 2 Mai 2023]. Disponível em: https://www. sozialministerium.at/Themen/Gesundheit/Impfen/Impfplan-Österreich. html.

Conseil Supérieur de la Santé. Vaccination contre l’herpès zoster virus (zona); 2017 [consultado 2 Mai 2023]. Disponível em: https://www.health. belgium.be/sites/default/files/uploads/fields/fpshealth_theme_file/9209_css_avis_zonaa5_pdt.pdf.

Superior Health Council of Belgium. Vaccination of immunocompromised or chronically ill children and/or adults; 2019 [consultado 2 Mai 2023]. Disponível em: https://www.health.belgium.be/sites/default/files/uploads/fields/fpshealth_theme_file/20191014_shc_9158_ic_and_vaccination_vweb. pdf.

Gobierno de España. Ponencia de Programa y Registro de Vacunaciones. Recomendaciones de vacunación frente a herpes zóster; 2021 [consultado 2 Mai 2023]. Disponível em: https://www.sanidad.gob.es/en/ profesionales/saludPublica/prevPromocion/vacunaciones/programasDeVacunacion/docs/HerpesZoster_RecomendacionesVacunacion.pdf.

Sociedad Española de Inmunología. Posicionamiento Sociedad Española de Inmunología sobre vacuna frente al herpes zoster em pacientes con inmunodeficiencias primarias; 2022 [consultado 2 Mai 2023]. Disponível em: https://www.inmunologia.org/index.php/ noticias/920-carta-sei-posicionamiento-vacuna-herpes-zoster-en-idp.

Santé Publiqué France. La vaccination au cours de la vie - Seniors (à partir de 65 ans); 2023 [consultado 2 Mai 2023]. Disponível em: https:// vaccination-info-service.fr/La-vaccination-au-cours-de-la-vie/Seniors-a- -partir-de-65-ans.

Ministry of Health Greece. 2018 [consultado 2 Mai 2023]. Disponível em: https://www.moh.gov.gr/articles/health/dieythynsh-dhmosias-ygieinhs/metadotika-kai-mh-metadotika-noshmata/ ethnika-programmata-emboliasmwn/5776-ethniko-programma-em boliasmwn-enhlikwn-2018-2019?fdl=13913.

Health Council of the Netherlands. Vaccination against shingles; 2019 [consultado 2 Mai 2023]. Disponível em: https://www.healthcouncil.nl/ documents/advisory-reports/2019/07/15/vaccination-of-older-people- -against-shingles.

National Immunisation Advisory Committee. Immunization guidelines. Chapter 23: Varicella-Zoster; 2022 [consultado 2 Mai 2023]. Disponível em: https://rcpi.access.preservica.com/uncategorized/IO_83ed18c1-91c1-46ac-9fe4-e29fc536a5d8/.

National Immunisation Advisory Committee. Immunization guidelines. Chapter 3: Immunisation of Immunocompromised Persons; 2023 [consultado 2 Mai 2023]. Disponível em: https://rcpi.access.preservica.com/ uncategorized/IO_33b8b2b2-1765-4709-aafa-535050d133e5/.

Ministero della Salute. Aggiornamento sulla vaccinazione contro herpes zoster [Italian update on herpes zoster vaccination]; 2021 [consultado 2 Mai 2023]. Disponível em: https://www.vaccinarsinpuglia.org/assets/ uploads/files/22/circolare-ministeriale-aggiornamento-sulla-vaccinazione- -contro-herpes-zoster.pdf.

Joint Committee on Vaccination and Immunisation. Minute of the meeting held on 06 February 2019; 2019 [consultado 2 Mai 2023]. Disponível em: https://app.box.com/s/iddfb4ppwkmtjusir2tc/file/424913874479.

SZU National Institute of Public Health (Czech Republic). Ockovací kalendár pro dospelé - podle veku [Vaccination calendar for adults - by age]; 2019 [consultado 2 Mai 2023]. Disponível em: https://szu.cz/wp-content/ uploads/2023/02/2019_Aktualiz_ockovaci_kalendar_dosp_.pdf.

SZU National Institute of Public Health (Czech Republic). Základní infor mace o infekcích v rámci ockování v CR I [Basic information on infections within vaccination in the Czech Republic]; 2023 [consultado 2 Mai 2023]. Disponível em: https://szu.cz/temata-zdravi-a-bezpecnosti/vakciny-a-ockovani/informace-o-infekcich-v-ramci-ockovani-v-cr-i/.

Folkhälsomyndigheten. Agência de Saúde Pública da Suécia. Vaccination mot bältros (herpes zoster); 2022 [consultado 2 Mai 2023]. Disponível em: https://www.folkhalsomyndigheten.se/smittskydd-beredskap/vaccinationer/vacciner-som-anvands-i-sverige/baltros/.

Office fédéral de la santé publique et Commission fédérale pour les vaccinations. Plan de vaccination suisse 2023; 2023 [consultado 2 Mai 2023]. Disponível em: https://www.infovac.ch/docs/public/-main/ofsp-plan-de-vaccination-2023-web-korr-menb-07-03-23.pdf.

Dooling KL, Guo A, Patel M, Lee GM, Moore K, Belongia EA, et al. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines. MMWR Morb Mortal Wkly Rep. 2018;67:103-8. doi:10.15585/mmwr.mm6703a5

Anderson TC, Masters NB, Guo A, Shepersky L, Leidner AJ, Lee GM, et al. Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022. MMWR Morb Mortal Wkly Rep. 2022;71:80-4. doi:10.15585/mmwr.mm7103a2

Australian Technical Advisory Group on Immunisation (ATAGI) | Clinical Ad vice. Statement on the Clinical Use of Zoster Vaccines in Adults in Australia; 2022 [consultado 2 Mai 2023]. Disponível em: https://www.health.gov. au/sites/default/files/documents/2022/05/statement-on-the-clinical-use- -of-zoster-vaccine-in-older-adults-in-australia-statement-on-the-clinical-use-of-zoster-vaccine-in-older-adults-in-australia.pdf.

Marra F, Parhar K, Huang B, Vadlamudi N. Risk factors for herpes zoster infection: a meta-analysis. Open Forum Infect Dis. 2020;7:ofaa005. doi:10.1093/ofid/ofaa005

Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang SJ, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015;372:2087-96. doi:10.1056/NEJMoa1501184

Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang SJ, Díez-Domingo J, et al. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. N Engl J Med. 2016;375:1019-32. doi:10.1056/NEJMoa1603800

Oostvogels L, Heineman TC, Johnson RW, Levin MJ, McElhaney JE, Van den Steen P, et al. Medical conditions at enrollment do not impact efficacy and safety of the adjuvanted recombinant zoster vaccine: a pooled post- -hoc analysis of two parallel randomized trials. Hum Vaccin Immunother. 2019;15:2865-72. doi:10.1080/21645515.2019.1627818

Schmader KE, Levin MJ, Gnann JW, McNeil SA, Vesikari T, Betts RF, et al. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Clin Infect Dis. 2012;54:922-8. doi:10.1093/cid/cir970

Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005;352:2271-84. doi:10.1056/NEJMoa051016

Merck & Co. Zostavax Prescribing Information: FDA; 2018 [consultado 2 Mai 2023]. Disponível em: https://www.fda.gov/media/82524/download.

Kennedy P, Gershon A. Clinical Features of Varicella-Zoster Virus Infection. Viruses. 2018;10:609. doi:10.3390/v10110609

Kim YJ, Lee CN, Lee MS, Lee JH, Lee JY, Han K, et al. Recurrence Rate of Herpes Zoster and Its Risk Factors: a Population-based Cohort Study. J Korean Med Sci. 2019;34:e1. doi:10.3346/jkms.2019.34.e1

Chen SY, Suaya JA, Li Q, Galindo CM, Misurski D, Burstin S, et al. Incidence of herpes zoster in patients with altered immune function. Infection. 2014;42:325-34. doi:10.1007/s15010-013-0550-8

Marra F, Lo E, Kalashnikov V, Richardson K. Risk of herpes zoster in individuals on biologics, disease-modifying antirheumatic drugs, and/or corticosteroids for autoimmune diseases: a systematic review and me ta-analysis. Open Forum Infect Dis. 2016;3:ofw205. doi:10.1093/ofid/ ofw205

UK Health Security Agency. Immunisation against infectious disease - The Green Book. [ebook] London: PHE. Chapter 28a - Shingles (herpes zoster); 2021 [consultado 2 Mai 2023]. Disponível em: https://assets. publishing.service.gov.uk/government/uploads/system/uploads/attach ment_data/file/1012943/Green_book_of_immunisation_28a_Shingles. pdf.

Parikh R, Widenmaier R, Lecrenier N. A practitioner’s guide to the recom binant zoster vaccine: review of national vaccination recommendations. Exp Rev Vaccin. 2021;20:1065-75. doi:10.1080/14760584.2021.195690 6

Nanishi E, Hoshina T, Takada H, Ishimura M, Nishio H, Uehara T, et al. A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. J Infect. 2016;73:358-68. doi:10.1016/j.jinf.2016.07.018

Bastidas A, de la Serna J, El Idrissi M, Oostvogels L, Quittet P, López- -Jiménez J, et al. Effect of recombinant zoster vaccine on incidence of herpes zoster after autologous stem cell transplantation: a randomized clinical trial. JAMA. 2019;322:123. doi:10.1001/jama.2019.9053

Dagnew AF, Vink P, Drame M, Willer DO, Salaun B, Schuind AE. Immune responses to the adjuvanted recombinant zoster vaccine in immunocom promised adults: a comprehensive overview. Hum Vaccin Immunother. 2021;17:4132-43. doi:10.1080/21645515.2021.1930846

Dagnew AF, Ilhan O, Lee WS, Woszczyk D, Kwak JY, Bowcock S, et al. Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in adults with haematological malignancies: a phase 3, randomised, clinical trial and post-hoc efficacy analysis. Lancet Infect Dis. 2019;19:988-1000. doi:10.1016/S1473-3099(19)30163-X

Berkowitz EM, Moyle G, Stellbrink HJ, Schürmann D, Kegg S, Stoll M, et al. Safety and Immunogenicity of an Adjuvanted Herpes Zoster Subunit Candidate Vaccine in HIV-Infected Adults: A Phase 1/2a Randomized, Placebo-Controlled Study. J Infect Dis. 2015;211:1279-87. doi:10.1093/ infdis/jiu606

Vink P, Ramon Torrell JM, Sanchez Fructuoso A, Kim SJ, Kim SI, Zaltzman J, et al. Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in chronically immunosuppressed adults following renal transplant: a phase iii, randomized clinical trial. Clin Infect Dis. 2020;70:181-90. doi:10.1093/cid/ciz177

Vink P, Delgado Mingorance I, Maximiano Alonso C, Rubio-Viqueira B, Jung KH, Rodriguez Moreno JF, et al. Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in patients with solid tumors, vaccinated before or during chemotherapy: A randomized trial. Cancer. 2019;125:1301-12. doi:10.1002/cncr.31909

Dagnew AF, Rausch D, Hervé C, Zahaf T, Levin MJ, Schuind A, et al. Efficacy and serious adverse events profile of the adjuvanted recombinant zoster vaccine in adults with pre-existing potential immune-mediated diseases: a pooled post hoc analysis on two parallel randomized trials. Rheumatology. 2021;60:1226-33. doi:10.1093/rheumatology/keaa424

Lenfant T, Jin Y, Kirchner E, Hajj-Ali RA, Calabrese LH, Calabrese C. Safety of recombinant zoster vaccine: a retrospective study of 622 rheumatology patients. Rheumatology. 2021;60:5149-57. doi:10.1093/rheumatology/ keab139

Källmark H, Gullstrand B, Nagel J, Einarsson J, Jönsson G, Kahn F,et al. Immunogenicity of adjuvanted herpes zoster subunit vaccine in rheumatoid arthritis patients treated with janus kinase inhibitors and controls: preliminary results. Arthritis Rheumatol. 2020; 72:suppl 10.

Stevens E, Weinblatt ME, Massarotti E, Griffin F, Emani S, Desai S. Safety of the zoster vaccine recombinant adjuvanted in rheumatoid arthritis and other systemic rheumatic disease patients: a single center’s experience with 400 patients. ACR Open Rheumatol. 2020;2:357-61. doi:10.1002/ acr2.11150

Cohen JI. Strategies for Herpes Zoster Vaccination of Immunocompromised Patients. J Infect Dis. 2008;197:S237-41. doi:10.1086/522129

López-Fauqued M, Campora L, Delannois F, El Idrissi M, Oostvogels L, De Looze FJ, et al. Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials. Vaccine. 2019;37:2482-93. doi:10.1016/j.vaccine.2019.03.043

Sociedad Española de Medicina Preventiva, Salud Pública y Gestión Sa nitaria. Consenso de la SEMPSPGS sobre la vacunación frente a herpes zóster; 2022 [consultado 2 Mai 2023]. Disponível em: https://www. sempspgs.es/es/-7-Prevencion-de-la-enfermedad-a-nivel-individual/140- -Consenso-de-la-SEMPSPGS-sobre-la-vacunacion-frente-a-Herpes- -Zoster.htm.

Strezova A, Diez-Domingo J, Al Shawafi K, Tinoco JC, Shi M, Pirrotta P, et al. Long-term protection against herpes zoster by the adjuvanted recombinant zoster vaccine: interim efficacy, immunogenicity, and safety results up to 10 years after initial vaccination. Open Forum Infect Dis. 2022;9:ofac485. doi:10.1093/ofid/ofac485

Morrison VA, Johnson GR, Schmader KE, Levin MJ, Zhang JH, Looney DJ, et al. Long-term persistence of zoster vaccine efficacy. Clinl Infect Dis. 2015;60:900-9. doi:10.1093/cid/ciu918

Yawn BP, Wollan PC, Kurland MJ, St. Sauver JL, Saddier P. Herpes zoster recurrences more frequent than previously reported. Mayo Clin Proc. 2011;86:88-93. doi:10.4065/mcp.2010.0618

Godeaux O, Kovac M, Shu D, Grupping K, Campora L, Douha M, et al. Immunogenicity and safety of an adjuvanted herpes zoster subunit candidate vaccine in adults ≥ 50 years of age with a prior history of herpes zoster: A phase III, non-randomized, open-label clinical trial. Hum Vaccin Immunother. 2017;13:1051-8. doi:10.1080/21645515.2016.1265715

Grupping K, Campora L, Douha M, Heineman TC, Klein NP, Lal H, et al. Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Subunit Vaccine in Adults Previously Vaccinated With a Live Attenuated Herpes Zoster Vaccine. J Infect Dis. 2017;216:1343-51. doi:10.1093/infdis/jix482

Dagnew AF, Klein NP, Hervé C, Kalema G, Di Paolo E, Peterson J, et al. The Adjuvanted Recombinant Zoster Vaccine in Adults Aged ≥65 Years Previously Vaccinated With a Live-Attenuated Herpes Zoster Vaccine. J Infect Diss. 2021;224:1139-46. doi:10.1093/infdis/jiaa083

Schwarz TF, Aggarwal N, Moeckesch B, Schenkenberger I, Claeys C, Douha M, et al. Immunogenicity and Safety of an Adjuvanted Herpes Zoster Subunit Vaccine Coadministered With Seasonal Influenza Vaccine in Adults Aged 50 Years or Older. J Infect Dis. 2017;216:1352-61. doi:10.1093/infdis/jix481

Maréchal C, Lal H, Poder A, Ferguson M, Enweonye I, Heineman TC, et al. Immunogenicity and safety of the adjuvanted recombinant zoster vaccine co-administered with the 23-valent pneumococcal polysaccharide vaccine in adults ≥50 years of age: A randomized trial. Vaccine. 2018;36:4278-86. doi:10.1016/j.vaccine.2018.05.110

Min JY, Mwakingwe-Omari A, Riley M, Molo LY, Soni J, Girard G, et al. The adjuvanted recombinant zoster vaccine co-administered with the 13-valent pneumococcal conjugate vaccine in adults aged ≥50 years: A randomized trial. J Infect. 2022;84:490-8. doi:10.1016/j.jinf.2021.12.033

Strezova A, Lal H, Enweonye I, Campora L, Beukelaers P, Segall N, et al. The adjuvanted recombinant zoster vaccine co-administered with a tetanus, diphtheria and pertussis vaccine in adults aged ≥50 years: A randomized trial. Vaccine. 2019;37:5877-85. doi:10.1016/j.vaccine.2019.08.001

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31-08-2023 — Atualizado em 27-09-2023

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Duque S, Marinho A, Almeida P, Marques Pereira R, Buzaco R. Recomendações para a Vacinação contra o Herpes Zoster: Documento de Consenso da Sociedade Portuguesa de Medicina Interna e da Associação Portuguesa de Medicina Geral e Familiar. RPMI [Internet]. 27 de Setembro de 2023 [citado 28 de Abril de 2024];30(3):180-91. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/1886

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