Sarcoma de Kaposi pulmonar na infeção por VIH

Autores

  • Eugénio Teófilo Interno do Internato Complementar de Medicina Interna Hospital de Santo António dos Capuchos, Lisboa
  • Pedro Figueiredo Assistente Hospitalar de Radiologia, Hospital de Santo António dos Capuchos, Lisboa

Palavras-chave:

herpesvirus humano 8, citoqui­nas, oncogénese, imagiologia, poliquimioterapia

Resumo

Oaparecimento recente do sarcoma de Kapo­si (SK) epidémico na prática clinica corrente da Medicina Interna veio permitir encontrar expres­sões clínicas raras, como a pulmonar (SKP). A radiologia tem um papel preponderante na ava­liação da extensão do SKP. A grande agressivi­dade que por vezes apresenta conduziu à inves­tigação denovas terapêuticas em diferentes áreas (imunomodulação, hormonal e citostática).

Os novos conceitos quanto à sua provável ori­gem talvez permitam que, a curto prazo seja mais uma profilaxia nos imunodeprimidos pelo VIH.

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Referências

Thomas A, Peterman TA, Harold W. Jaffe, Valerie Beral Epide­miologic Clues to the Etiology of Kaposi's Sarcoma. AIDS 1993; 7:605-611.

Kasolo FC, Mpabalwani E, Gompels UA. Infection With AIDS­ Related Herpesvirus in Human Immunodeficiency Negati­ve Infants and Endemic Childhood Kaposi's Sarcoma in Africa. J Gen Virol 1997; 78(Pt4): 847-855.

Alkan S, Karcher DS, Ortiz A et al. Human Herpesvirns-8/ Kaposis Sarcoma Associated Herpevirus in Organ Transplant Pati­ents With lmmunossupression. Br J Haematol 1997; 96(2): 412-414.

Lesnoni la Parola I, Masini C, Nanni G et al. Kaposi's Sarcoma in Renal-Transplant Recipients: Experience at the Catholic University in Rome 1988-1996. Dermatology1997; 194(3): 229-233.

Dezuhe BJ. Clinical Presentation and Natural History of AIDS Related Kaposi's Sarcoma. Hematol Onc Clin 1996;10 (5): 1023-1029.

Karp JE, Pluda M, Yarchoan R. AIDS-Related Kaposi's Sarcoma. Hematol Onc Clin 1996;10 (5): 1031-1049.

Paul J. Veuglers, Steffanie A. Strathdee, John M. Kaklor et al. Associations of Age, lmunossupression and AIDS, Among Homosexual Men in the Tricontinental Seroconverter Stu­dy. J AIDS and Hum Retro 1997; 14(5): 435-441.

Hermans P, Lundgren J, Sommereijns B et al. Epidemiology of AIDS-Related Kaposi's Sarcoma in Europe over 10 Years. AIDS 1996 ;10(8): 911-918.

Boshoff C, Weiss RA. Kaposis sarcoma-associated herpesvirus. Cur Opin Infect Dis 1997; 10:26-31.

Biggar RJ, Rbakin CS. The Epidemiology of AIDS Related Neo­plasms in Hematol Onc Clin 1996;10 (5): 997-1010.

Cooley TP, Hirschhorn I.R, O'Keane JC. Kaposi's Sarcoma in Women With AIDS. AIDS 1996; 10(11): 1221-1226.

Diego Serraino, Silvia Franceschi, Luisino Dai Maso, Cario La Vecchia. HIV Transmission and Kaposi's Sarcoma Among European Women. AIDS 1995; 9:971-973.

Grulich AE, Kaklor JM, Hendry O, et al. Risk of Kaposi's Sarco­ma and Oroanal Sexual Contact. Am J Epidemiol 1997; 145(8): 673-679.

Seilhean D, Lazarini F, Suarez S et al. Frequency of Kaposi's sarcoma in European AIDS patients who stayed in Africa. AIDS 1997; 11: 1401-1402.

Chang Y, Cesarman E, Pessin MS et al. Identification of Her­ pes-Like DNA Sequences in AIDS-Associated Kaposi's Sar­coma. Science 1994; 266:1865-1869.

Ethel Cesarman, Yuan Chang, Patrcik S. Moore, et al. Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity-Based Lymphomas. N Engl J Med 1995; 332: 1186-1191.

Karcher DS, Alkan S. Human Herpesvirus 8-Associated Body Cavity Based Lymphoma in Human Immunodeficiency Vi­rus-Infected Patients: a Unique B-Cell Neoplasm. Hum Pa­thol 1997; 28(7): 801-808.

Cesarman E, Knowles DM. Kaposi's Sarcoma-Associated Her­pesvirus: a Lymphotropic Human Herpesvirus Associated with Kaposi's Sarcoma, Primary Effusion Lymphoma and Multicentric Castleman's Disease. Semin Diagn Pathol 1997: 14(1): 54-56.

Corhellino M, Poirel L, Bestitti G et al. Human Herpesvirus-8 in AIDS-Related and Unrelated Lymphomas. AIDS 1996; 10(5): 545-546.

Gaidano G, Pastore C, Gloghini A, et al. Distribution of Human Herpesvirus 8 Sequences Through the Spectrum of AIDS­ Related Neoplasia. AIDS 1996; 10(9): 941-950.

Grandadam M, Dupin N, Calvez Vetai. Exacerbation of Clini­cal Symptoms in Human Immunodeficiency Virus Type 1 Infected Patients With Multicentric Castleman's Disease are Associatecl With a High Increase in Kaposi's Sarcoma Her­pesvirus DNA Load in Peripheral Blood Mononuclear Cells. J Infect Dis 1997; 175(5): 1198-1201.

Cesarman E, Knowles DM. Kaposi's Sarcoma-Associated Her­pesvirus: a Lymphotropic Human Herpesvirus Associated With Kaposi's Sarcoma, Primary Effusion Lymphoma and Multicentric Castleman's Disease. Semin Diagn Pathol 1997;14(1): 54-66.

Karcher OS, Alkan S. Human Herpesvirus-8-Associated Body Cavity-Based Lymphoma in Human lmmunodeficiency Vi­rus-Infected Patients: a Unique B-Cell Neoplasm. Hum Pa­ thol 1997; 28(7): 801-808.

De Pond W, Said JW, Tasaka Tet al. Kaposi's Sarcoma-Associa­ted Herpesvirus and Human Herpesvirus 8 (KSHV/HHV8)­ Associated Lymphoma of the Bowel. Repon of Two Cases in HIV-Positive Men With Secondary Effusion Lymphomas. Am J SurgPathol 1997: 21(6):719-724.

Said JW, Tasaka T, de Vos S, Koefller HP. Kaposi's Sarcoma­ Associated Herpesvirus / Human Herpesvirus Type 8 Ence­phalitis in HIV-Positive and Negative Individuals. AIDS 1997: 11(9): 1119-1122.

Detection of Antibodies Against Viral Capsid Proteins of Hu­man Herpesvirus 8 in AIDS-Associated Kaposi's Sarcoma. Andre S, Schatz O, Bogner JR et al. J Mol Med 1997; 75(2): 145-152.

Koelle DM, Huang MG, Chandran B et al. Frequent Detection of Kaposi's, Sarcoma-Associated Herpesvirus (Human Her­pesvirus 8) DNA in Saliva of Human Immunodeficiency Virus-Infected Men: Clinical end Immunological Correlates. J Infect Dis 1997; 1760): 94-102.

Smith MS, Bloomer C, Horvart R et ai. Detection of Human Herpesvirus 8 DNA, in Kaposi's Sarcoma Lesions and Peri­pheral Blood of Human Immunodeficiency Virus-Positive Patients and Correlation with Serological Measurements. J Infect Dis 1997; 176(1): 84-93.

Rizzieri DA, Liu J, Miralles D, Traweek ST. Kaposi's Sarnoma­ Associated Herpesvirus is Detected in Peripheral Blood Mononuclear Cells of HIV-Infected Homosexuals More Often Than in Heterosexuals. CancerJ Sci Am 1997; 3(3): 153- 156.

Howard MR, Whitby D, Bahadur G, et al. Detection of Human Herpesvirus 8 DNA in Semen from HIV-Infected Individu­als but Not from Healthy Semen Donors. AIDS 1997; 11(2): F15-F19.

Viviano E, Vitale F, Alejo F, et al. Human Herpesvirus Type 8 DNA Sequences in Biological Samples of HIV-Positive and Negative Individuals in Sicily. AIDS 1997; 11(5): 607-612.

Davis Da, Humphrey RW, Newcomb FM et al. Detection of Serum Antibodies to Kaposi's Sarcoma-Associated Herpes­ virus-specific Peptide. J Infect Dis 1997; 175(5): 1071-1079.

Webster-Cyriaque J, Edwards RH, Quinlivan EB, et al. Ebstein­ Barr Virus and Human Herpesvirus 8 Prevalence in Human lmmunodeficiency Virus-Associated Oral Mucosa Lesions. J Infect Dis 1997: 175(6): 1324-1332.

Kennedy MM, Lucas SB, Jones RR et al. HHV8 and Kaposi's Sarcoma: a Time Cohorl Study. Mol Pathol 1997; 50(2): 96- 100.

Moore PS, Kingsley LA, Holmberg SD et al Kaposi's Sarcoma­ Associated Herpesvirus lnfection Prior to Onset of Kaposi's Sarcoma. AIDS 1996;10(2):175-180.

Patrick S. Moore, Yuan Chang. Detection of Herpes-Like DNA Sequences in Kaposi's Sarcoma in Patients With And Those Without HIV lnfection. N Engl J Med 1995; 332:1181-1185.

Miles SA. Pathogenesis of AIDS-Related Kaposi Sarcoma. Hematol Onc Clin 1996;10 (5): 1011-1021.

Dourado I, Martinez-Maz O, Kishimoto T et al. lnterleukin 6 and AIDS-Associated Kaposi's Sarcoma: a Nested Case Control Study Within the Multicenter AIDS Cohort Study. AIDS Res Hum Retroviruses 1997; 13(9): 781-788.

Ambrosino C, Ruocco MR, Chen X et al HIV-1 Tat Induces the Expression of The lnterleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting With CAAT Enhan­cer-Binding Protein Beta (NF-IL6) Transcripton Factors. J Biol Chem 1997; 272(23): 14883-14892.

Nakamura S, Murakami-Mori K, Rao N et ai. Vascular Endothe­lial Growth Factor is a Potent Angiogenic Factor in AIDS­ Associated Kaposi's Sarcoma-Derived Spindle Cells. J Im­munol 1997; 158(10): 4992-5001.

Charles Rabkin, SigfriedJanz, Alex Lash et al. Monoclonal Ori­gin of Multicentric Kaposi's Sarcoma Lesions. N Engl J Med 197; 336:988-993.

Krown SE; Huang J, Testa M. Validation and Refinement of the ACTG Staging System-for AIDS Associated Kaposi's Sarco­ma (KS). National AIDS Malignancy Conference (Abstract 19), 28-30 Abril 1997.

White DA. Pulmonary complications of HIV-associated Malignancies. Clin Chest Med 1996: 17 (4); 755-761

Pozniak AL, Latif AS, Neill P, et al. Pulmonary Kaposi's Sarcoma in Africa. Thorax 1992; 47 (9); 730-733

Mitchell DM, McCarty M, Fleming J, Moss FM. Bronchopulmo­nary Kaposi's Sarcoma in Patients With AIDS. Thorax 1992; 47(9): 726-729.

Huang L, Schnapp LM, Gruden JF et al. Presentation of AIDS­ Related Pulmonary Kaposi's Sarcoma Diagnosed by Bron­choscopy. Am J Respir Crit Care Med 1996; 153(4): 1385-1390.

Gruden JF, Huang L, Webb WR et al. AIDS-Related Kaposi's Sarcoma of the Lung: Radiographic Findings and Staging System With Bronchoscopic Correlation. Radiology 1995; 195(2): 545-552.

Benfield TL, Dodt KK, Lundgren JD. Human Herpesvirus 8 DNA in Bronchoalveolar Lavage Sampies from Patients with AIDS-Associated Kaposi's Sarcoma. Scand J Inf Dis 1997; 29 (1): 13-16.

Cathomas G, Tamm M, McGandy CE et al. Detection of Herpesvirus-Like DNA in the Bronchoalveolar Lavage Fluid of Patients With Pulmonary Kaposi's Sarcoma. Eur Respir J 1996; 9(8): 1743-1746.

Howard MR, Brink .NS, Tedcler RS, Miller RF. Detection of Her­pesvirus-Like DNA in the Bronchoalveolar Lavage Fluid From HIY-Infected Patients With and Without Pulmonary Kaposi's Sarcoma. National AIDS Malignancy Conference [Abstract 181, 28-30 Abril 1997.

Lee VW, FullerJD, O'Brien MJ et al. Pulmonary Kaposi's Sarco­ma in Patients with AIDS: Scintigraphic Diagnosis with Tha­lium and Galium Sacanning. Radiology 1991; 180: 409-412.

Yang Gc, Brooks JJ. Roberts S, Gupta PK. The Detection of Acquired Immunodeficiency Syndrome-Associated Kaposi Sarcoma Cells in Pleural Effusion by CD 34 Immunostain. Cancer 1993; 72(7): 2260-2265.

Gruden JF, Huang L, Wehh WR, Gamsu G, Hopwell PC, Sides DM. AIDS-related Kaposi Sarcoma of the Lung: Radiogra­phic Findings and Staging System with Bronchoscopic Cor­relation. Radiology 1995; 195:545-552.

Heitzman RE. Pulmonary Neoplastic and Lymphoproliferative Disease in AIDS: A Review. Radiology 1990; 177:347-351.

Lafeuillade A, Poizot-Martin I, Dhiver C, Giovannini M, Yiallat JR, Quilichini R, Bouabdallah R, Gastaut JA. Maladie de Ka­posi au cours du SIDA - Soixante-dix observations. La Pres­se Médicale 1991; 20 (3): 113-116.

Grenier Ph, Brauner M. lmagerie des manifestations thoraci­ques du SIDA in Bellin MF, Brunelle F, Grenier Ph, Martin N, Menu Y, Vildé JL, Imagerie du SIDA. Flammarion, Paris. 1991.

Murray JF, Goodman PC. HIV infection and AIDS: intrathora­cic complications in Grainger RG, Allison DJ, Diagnostic Radiology· Churchill Livinstone, Edinburgh, 1992.

Khalil AM, Carette MF, Cadranel LL, Mayaud ChM, Akoun GM, Bigot JM. Magnetic resonance imaging findings in pulmo­nary Kaposi's sarcoma: a series of 10 cases. Eur Respir J 1994: 7:1285-1289.

Feigal EG, vem Roen J, Justice R et al. Kaposi's Sarcoma Res­ponse Criteria: Issues Identified by The National Cancer Institute, Food and Drug Administration, and the AIDS Malig­nancy Consortium. National AIDS Malignancy Conference (Abstract 24), 28-30 Abril 1997.

Alhini A, Paglieri I, Orengo G et al. The B-core Fragment of Human Chorionic Gonadotrophin Inhibits Growth of Kaposi's Sarcoma Derived Cells and a New Immortalized Kaposi's Sarcoma Cell Line. AIDS 1997; 11(6): 713-722.

Bouscarat F, Dazza MC, Maelchior JC, Bouvet E. Kaposi's Sar­coma and Sex Hormones. AIDS 1997; 11(5): 687-688.

Tirelli U, Tavio M, Giacca M, De Paoli P. Human Corionic Go­nadotropin in the Treatment of HIY-Related Kaposi's Sar­coma. AIDS 1997; 11(3): 387-388.

Lang ME, Lottersherger L, Roth B et al. Induction of apoptosis in Kaposi's sarcoma spindle cell cultures by the subunits of human chorionic gonadotropin. AIDS 1997; 11: 1333-1340.

Kedes DH, Ganem D. Sensitivity of Kaposi's Sarcoma-Associa­ ted Herpesvirus Replication to Antiviral Drugs. Implications for potencial Therapy. J Clin Invest 1997; 99(9): 2082-2086.

Meclveczky MM, Horvarth E, Luncd T, Medveckzi PG. ln vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus. AIDS 1997: 11: 1327-1332.

Mocroft A, Youle M, Gazzard B et al. Anti-Herpesvirus Treat­ment and the Risk of Kaposi's Sarcoma in HIV Infection. AIDS 1996; 10(10): 1101-1106.

Connant MA, Opp KM, Poretz D, Milss RG. Reduction of Kaposi's Sarcoma Lesions Following Treatment of AIDS With Ritonavir. AIDS 1997; 11(10): 1300-1301.

Murphy M, Armstrong D, Sepkowitz KA et al. Regression of AIDS-Related Kaposi's Sarcoma Following Treatment with an HIV-1 Protease Inhibitor. AIDS 1997; 11(2): 261-262.

Routy JP, Urhaneck A, McLeod J, Thomas R. Significant Regres­sion of Kaposi's Sarcoma Following Initiation of an Effecti­ve Antiretroviral Combination Treatment. National AIDS Malignancy Conference (Abstract 23) 28-30 Abril 1997.

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Publicado

30-09-1998

Como Citar

1.
Teófilo E, Figueiredo P. Sarcoma de Kaposi pulmonar na infeção por VIH. RPMI [Internet]. 30 de Setembro de 1998 [citado 25 de Junho de 2024];5(3):187-93. Disponível em: https://revista.spmi.pt/index.php/rpmi/article/view/2146

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