Úlceras esofágicas idiopáticas em mulher VIH+: terapêutica com talidomida
Palavras-chave:
talidomida, VIH, SIDA, úlceras esofágicas idiopáticas, esofagiteResumo
Apresenta-se o caso clínico de uma doente seropositiva para o virus da imunodeficiência humana (VIH+) com um quadro de esofagite idiopática com excelente resposta à terapêutica com talidomida, associando-se regressão do síndrome febril que se manifestara concomitantemente. O mecanismo de acção da talidomida nestes casos é desconhecido, mas poderá estar relacionado com os efeitos do fármaco sobre o sistema imunitário ou dever-se a um efeito anti-retroviral directo.
Downloads
Referências
Connolly GM, Hawkins D, Harcourt-Webster JN, Parsons PA, Husain OAN, Gazzard BG. Oesophageal symptoms, their causes, treatment, and prognosis in patients with the acquired immunodeficiency syndrome. Gut 1989; 30: 1033-1039
Laine L, Bonacini M. Esophageal disease in human immunodeficiency virus infection. Arch Intern Med 1994; 154: 1577-
Kitchen VS, Helbert M, Francis ND, et al. Epstein-Barr virus associated oesophageal ulcers in AIDS. Gut 1990; 31: 1223-1225.
Rabeneck L, Popovic M, Gartner S, et al. Acute HIV infection presenting with painful swallowing anel esophageal ulcers. JAMA 1990; 263; 2318-2322.
Wilcox CM, Schwartz DA, Clark WS. Esophageal ulceration in human immunodeficiency virus infection. Causes, response to therapy, and long-term outcome. Ann Intern Med 1995; 122: 143-149.
Youle M, Clarbour J, Farthing C, et al. Treatment of resistant aphtous ulceration with thalielomide in patients positive for HIV antibody. Br Med J 1989; 298: 432.
Ghigliotti G, Repeno T, Farris A, Roy MT, De Marchi R. Thalidomide: Treatment of choice for aphtous ulcers in patients seropositive for human immunodeficiency virus. J Am Acad Dermatol 1993; 28: 271-272.
Ryan J, Colman J, Pedersen J, Benson E. Thalidomiele to treat esophageal ulcer in AIDS. New Engl J Med 1992; 327: 208- 209
Bodokh I, Lacour JP, Rainero C, Castanet J, Michiels JF, Ortonne JP. Efficacité du thalidomide sur les ulcérationsoeso phagiennes au cours ele l'infection à VIH. Presse Méd 1993; 22: 1233.
Paterson DL, Georghiou PR, Allworth AM, Kemp RJ Thalidomiele as treatment of refractory aphtous ulceration related to human immunodeficiency infection. Clin Inf Ois 1995; 20: 250-254.
Couderc IJ, Mathez D, Leibowitch J, Autran B, Caubarrere I. Traitement prolongé par thalidomide chez un malade infecté parle VIH. Presse Méd 1995; 24: 40.
Naum SM, Molloy PJ, Kania RJ, McGarr J, Van Thiel DH. Use of thalielomide in treatment and maintenance of idiopathic esophageal ulcers in HIV+ individuais. Dig Dis Sci 1995; 40: 1147-1148.
Revuz J, Guillaume J-C, Janier M, et al. Crossover study of thalidomide vs placebo in severe recurrent aphtous sto matitis. Arch Dermatol 1990; 126: 923-927.
Gutiérrez-Rodríguez O, Starusta-Bacal P, Guttiérrez-Montes O, et al. Treatment of refractory rheumatoied arthritis - the thaliclomide experience. J Rheumatól 1989; 2: 158-163.
Vogelsang GB, Farmer ER, Hess AD, et al. Thalidomide for the treatment of chronic graft-versus-host disease. New Engl J Med 1992; 326: 1055-1058.
Ochonisky S, Revuz J, Utilisation thérapeutique du thalidomide. Cone Méd 1995; 117: 98-102.
Strazzi S, Lebbe C, Geoffray C, et al. Aphtous ulcers in HIV infected patients: treatment with thalidomide. Genitour Med
; 68: 424-425.
Georghiou PR, Allworth AM. Thalidomide in painful AIDS associated proctits. J Infect Dis 1992; 166: 939-940.
Verberkmoes A, Boer K, Wertheim P, Bronkhorst CM, Lange J. Thalidomide for genital ulcer in HIV-positive woman. Lancet 1996; 347: 974.
Makonkawkeyoon S, Limson-Pobre RN, Moreira AL, Schauf V, Kaplan G. Thalidomide inhibits the replication of immunodeficiency vírus type 1. Proc Natl Acad Sci USA 1993; 90: 5974-5978.
Sampaio EP, Kaplan G, Miranda A, et al. The influence of thalidomide on the clinical and immunologic manifestations of erythema nodosum leprosum. J lnfect Dis 1993; 168: 408- 414.
Schuler U, Ehninger G. Thalidomide: Rationale for renewed use in immunological disorders. Drug Safety 1995; 12: 364-369.
Sharpstone D, Rowbottom A, Nelson M, et al. The treatment of microsporidial diarrhoea with thalidomide. AIDS 1995; 9: 658-959.
Thalidomide available to AIDS patients under expanded access program. Http://www.healthworks.eo.uk/hw/news/ DoctorsGuide4.html.
Ficheiros Adicionais
Publicado
Como Citar
Edição
Secção
Licença
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição 4.0.
Direitos de Autor (c) 2023 Medicina Interna
Acesso livre
