Thrombophilia and recurrent miscarriages
Keywords:
Thromboembolism, miscarriages, low molecular weight heparin, thrombophiliaAbstract
Hereditary and acquired thrombophilia are associated with recurrent miscarriages. Anti-thrombotic therapy can re-establish
the haemostatic balance and improve the prognosis during pregnancy.
In this article, the authors make an introduction to thrombophilia associated with obstetric complications, including some
therapeutic and prophylactic aspects, of thromboembolic events
during pregnancy.
Downloads
References
Benner B. Inherited thrombophilia and pregnancy loss. Thromb Haemost 1999; 82 .635-640
Rosendaal FR. (1999) Venous thrombosis: a multicausal disease. Lancet 353: 1167-1173.
Federman DG, Kirsner RS. An Update on Hypercoagulable Disorders. Arch Intern Med 2001; 161:1051-1056.
Martinelli I, De Stefano V, Taioli E et al. Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. Thromb Hemost 2002; 87: 791-795.
Martinelli I, Legnaci C, Bucciarelli P et al. Risk of pregnancy – related venous thrombosis in carriers of severe inherited thrombophilia. Thromb Haemost 2001; 86:800-803.
Franco RF. Trombofilias hereditárias. Medicina, Ribeirão Preto 2001; 34 : 248-257.
Franco RF, Reitsma PH. (2001) Genetic risk factors of venous thrombosis. Human Genetics 2001; 109: 369-384.
Bokarewal MI, Bremme K, Blomback M. Arg 506-Gin mutation infactor V and risk of thrombosis during pregnancy. Br J haematol 1996; 92:473-478.
Kiekebusch G, Perucca EP. Trombofilias hereditárias. Rev Chil Obset Ginecol 2003; 68(5): 424-429.
Preston FE, Rosendaal FR, Walker ID et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348:913-916.
Lane DA, Grant PJ. (2000) Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 95: 1517-1532.
Silveira PRM. Trombose Venosa Profunda e gestação: aspectos etiopatogénicos e terapêuticos: J Vasc BR 2002; 1 (1): 65-70.
Riszatti EG, Franco RF. Tratamento do tromboembolismo venoso - Simpósio Hemostasia e trombose, Capitulo V, 2003 : 269-275.
Kupferminc MJ, Eldor A, Steinman N et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J med 1999; 340:9-13.
Vilela SV, Jesus NR, Levy RA. Anticoagulação durante a gestação. Rev Bras Reumatol 2002; 42 (5): 311 -316.
Thromboprophylaxis during pregnancy, labour and after vaginal delivery; RCOG Guideline nº 37 2004
Additional Files
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Medicina Interna