Síndrome de Libertação de Citocinas em Doentes sob Tratamento Oncológico com CAR-T
DOI:
https://doi.org/10.24950/rspmi.287Palavras-chave:
Receptores de Antígenos de Linfócitos T, Receptores de Antígenos Quimérico, Síndrome de Libertação de Citocinas/tratamento farmacológicoResumo
Dado o desenvolvimento e crescente utilização da imunoterapia como opção terapêutica na doença oncológica, nomeadamente através de células T recetoras de antigénio quimérico (CAR-T), torna-se essencial uma expansão do conhecimento da gestão das toxicidades associadas. A síndrome de libertação de citocinas (SLC) e a neurotoxicidade associada a terapêuticas com CAR-T são as duas condições mais frequentes e são não só potencialmente fatais, mas também de difícil diagnóstico, uma vez que mimetizam outras patologias, como a sépsis. Com esta revisão bibliográfica, pretendemos caracterizar a SLC em doentes oncológicos sob terapêutica com CAR-T, com um enfoque particular na clínica e gestão terapêutica desta síndrome.
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Direitos de Autor (c) 2022 Medicina Interna
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição 4.0.
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