Kikuchi-Fujimoto’s disease in a black patient
Keywords:
Kikuchi-fujimoto’s disease, histiocytic necrotizing lymphadenitis, lymphadenopathyAbstract
Kikuchi-Fujimoto’s disease is a benign, self-limited, rare condition
of unknown aetiology. It presents has cervical lymphadenopathies
associated to constitutional symptoms and it is frequently associated with other systemic diseases. Differential diagnosis with
lymphoproliferative (ex: Lymphoma), infectious (ex: tuberculosis)
and autoimmune (ex: SLE) diseases should be made. Diagnostic
confirmation is histological, and treatment is usually symptomatic.
The authors report a case of a 22 year old black female patient, with no relevant past medical history, admitted with a 15
day ongoing complaints of high fever, associated with profuse
sweating and discrete cervical and axillary lymphadenopathies.
After performance of several negative or inconclusive diagnostic
studies, an excisional biopsy of a cervical node showed a morphologic pattern suggesting Kikuchi´s disease. Differential diagnosis
with lymphoma, tuberculosis and systemic erythematosus lupus
was then made. Repetition of EBV serologies, as an outpatient,
confirmed a likely association of this virus with the disease, with
descending titters.
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References
Norris AH, Krasinskas AM, Salhany KE et al: Kikuchi-Fujimoto disease: a benign cause of fever and lymphadenopathy. Am J Med 1996; 171: 401-405.
Reichert A, Correia T, Freitas O, Almeida T, Lino Rosado: Doença de Kikuchi e Fujimoto. Acta Méd Port 2005; 18: 231-234.
Meyer O: La maladie de Kikuchi. Ann Med Interne 1999; 150: 199-204.
Magnani G, Cocca G, Mezzadri S et al. Kikuchi’s disease: an uncommon cause of fever of unknown origin. Ann Ital Med Int 1999; 14: 205-208.
Vodoff MV, Petit B, Vinh D et al. La maladie de Kikuchi-Fujimoto. Arch Pediatr 2001; 8: 611-613.
Yoshino T, Mannami T, Ichimura K et al. Two cases of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) following diffuse large B-cell lymphoma. Hum Pathol 2000; 31(10): 1328-1331.
Mahadeva U, Allport T, Bain B et al. Haemophagocytic syndrome and histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). J Clin Pathol 2000; 53(8): 636-638.
Wilkinson CE, Nichol F: Kikuchi-Fujimoto disease associated with polymiositis. Rheumatology (Oxford) 2000; 39(11): 1302-1304.
Lyberatos C: Two more cases of Still’s disease and Kikuchi’s. J Rheumatol 1990; 17: 568-569.
Dorfman RF, Berry GJ: Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 1988; 5: 329-345.
Pina R., Fonseca I, Saldanha M.H: Doença de Kikuchi-Fujimoto: Uma causa pouco frequente de adenopatias cervicais, Medicina Interna 2004, 11 (4): 187-190.
Lopez C, Olivier M, Olavarria R, Sarabia MA, Chopite M: Kikuchi-Fujimoto necrotizing lymphadenitis associated with cutaneous lupus erythematosus: a case report. Am J Dermatopathol 2000; 22 (4): 328-333.
Diebold J: Lymphadénite histiocytaire nécrosant sans réaction granulocytairede Kikuchi-Fujimoto. Rev Med Interne 1996; 15: 981-983.
Kuo TT: Kikuchi disease (histyocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 1995; 19: 798-809.
Ohshima K, Kikuchi M, Sunlyoshi Y et al. Proliferating cells in histiocytic necrotizing lymphadenitis. Virchows Arch B Cell Pathol Incl Mol Pathol 1991; 61: 97-100.
Chan JK, Wong KC, Ng CS: A fatal case of multicentric Kikuchi’s histiocytic necrotizing lymphadenitis. Cancer 1989; 63: 1856-1862.
Shih-Hua L, Wang-Sheng K, Herng-Sheng L et al. Kikuchi’s disease associated with lupus-like syndrome – a fatal case [Letter]. Journal of Rheumatology 1992; 19: 1995-1996
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