Toxic hepatitis with interferon Beta-1a

Authors

  • Sara Drumond Freitas Serviço de Medicina Interna do Hospital Senhora da Oliveira, Guimarães
  • Helena Sarmento Serviço de Medicina Interna do Hospital Senhora da Oliveira, Guimarães
  • Glória Alves Serviço de Medicina Interna do Hospital Senhora da Oliveira, Guimarães
  • Jorge Cotter Serviço de Medicina Interna do Hospital Senhora da Oliveira, Guimarães

Keywords:

toxic hepatitis, liver tests, interferon-beta, multiple sclerosis

Abstract

Interferon beta-1a is one of the drugs, which is more frequently
used among patients with multiple sclerosis. Some of the collateral
effects of this drug are known, such as, injection site reactions,
liver tests abnormalities, livedo reticularis, positivity to autoantibodies, haematological and neuropsychiatric abnormalities.
The authors report a case of a patient with multiple sclerosis
treated with interferon beta-1a, who developed an acute hepatitis, in two different occasions.
It was made a bibliographic research of this theme.

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References

Navarro VJ, Senior JR. Current Concepts. Drug-Related Hepatotoxicity. N Engl J Med 2006; 354: 731-739.

Gordon SF, Yves G, Enrica A, Alain M et al. Hepatic Reactions During Treatment of Multiple Sclerosis. Incidence and Clinical Significance. Drug Safety 2003; 26 (11): 815-827.

Tremlett H, Yoshida E, Oger J. Liver Injury Associated With the betaInterferons for MS. A comparison between three products. NEUROLOGY

; 62: 628-631.

Jules LD, Kurt JH. Toxic and drug-induced hepatitis. In Harrison’s Principles of Internal Medicine 17 th edition, McGraw-Hill 2008; 1949-1955.

Willis M. Drug Induced Hepatotoxicity 2005. J Clin Gastroenterol. 2005; 39: S83-S89.

Tremlett H, Oger J. Elevated aminotransferases during treatment with interferon-beta for multiple sclerosis: actions and outcomes. Multiple Sclerosis 2004; 10: 298-301

Additional Files

Published

2009-12-31

How to Cite

1.
Drumond Freitas S, Sarmento H, Alves G, Cotter J. Toxic hepatitis with interferon Beta-1a. RPMI [Internet]. 2009 Dec. 31 [cited 2024 Nov. 23];16(4):230-3. Available from: https://revista.spmi.pt/index.php/rpmi/article/view/1430

Issue

Vol. 16 No. 4 (2009): Outubro/ Dezembro

Section

Case Reports

License

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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